Myristica fragrans Derived Phytochemicals against Shikimate Dehydrogenase of E. coli Causing Diarrhea
Sunanya Das
Centurion University of Technology and Management, Odisha, India.
Debasmita Das
Centurion University of Technology and Management, Odisha, India.
Ashrumochan Nayak
Centurion University of Technology and Management, Odisha, India.
Sonali Dash
Centurion University of Technology and Management, Odisha, India.
Dipankar Bhattacharyay *
Centurion University of Technology and Management, Odisha, India. and Go to Market Laboratory, Gram Tarang, Odisha, India.
*Author to whom correspondence should be addressed.
Abstract
Medicinal plants play a key role in human health care. Phytochemicals can be derived from different parts of plants. Different medicinal plants and their phytoextracts have shown anti-microbial action. Phytochemicals from Myristica fragrans plant extract are traditionally used to cure Diarrhea. Molecular docking method applied using “Biovia Discovery Studio”. “High positive values of -CDOCKER energy and -CDOCKER interaction energy” suggested that Eugenol can effectively deactivate the shikimate dehydrogenase enzyme thereby interrupting the life cycle of the organism.
Keywords: Phytochemical, Myristica fragrans, diarrhea, enzyme