Formulation and Characterization of Poly Sulfoxyamine Grafted Chitosan Coated Contact Lens
Rahul Laxman Jadhav *
Department of Pharmaceutical Chemistry, Gourishankar Institute of Pharmaceutical Education and Research, Limb, Satara, Maharashtra, 415001 India.
Sonali Gulab Sonwalkar
Department of Pharmaceutical Chemistry, Gourishankar Institute of Pharmaceutical Education and Research, Limb, Satara, Maharashtra, 415001 India.
Manisha Vyankatrao Patil
Department of Pharmaceutics, Adarsh College of Pharmacy, Vita, Sangli, Maharashtra, 416416, India.
Siraj N. Shaikh
Department of Pharmaceutics, Ali-Allana College of Pharmacy, Akkalkuwa, Nandurbar, Maharashtra, 425415, India.
Santosh N. Belhekar
Department of Pharmacology, Gourishankar Institute of Pharmaceutical Education and Research, Limb, Satara, Maharashtra, 41500 India.
*Author to whom correspondence should be addressed.
Abstract
Aim: The aim this research work is to formulate and characterize Poly Sulfoxyamine Grafted Chitosan Coated contact Lens.
Methodology: Poly Sulfoxyamine Grafted Chitosan was used for coating the Lens & converting it in to Antimicrobial Lenses. Poly Sulfoxyamine Grafted Chitosan was performed in the presence of pyridine and further treatment with ammonia during reaction of Thionyl chloride & chitosan. The UV light interference, visible light transmission and antimicrobial evaluation were studied.
Results: The results indicate that Contact lenses prepared with Modified Poly Sulfoxyamine Grafted Chitosan absorbed some UV radiation & does not interfere with visible region. Due to the antimicrobial activity of modified Chitosan, the growth and transmission of micro organisms are reduces in coated Lens as compared to uncoated Lens.
Conclusion: On basis of the results we concluded that Modified Poly Sulfoxyamine Grafted Chitosan might be used as coating material or material for making contact Lenses which will be less susceptible for microbial contamination.
Keywords: Poly sulfoxyamine grafted chitosan, contact lens, antimicrobial activity, UV light, chitosan.