Formulation, Development and Evaluation of Ibuprofen Loaded Nano-transferosomal Gel for the Treatment of Psoriasis
Marwa H. Abdallah *
Department of Pharmaceutics, College of Pharmacy, University of Ha’il, Saudi Arabia and Department of Pharmaceutics, Faculty of Pharmacy, Zagazig University, Egypt.
Amr S. Abu Lila
Department of Pharmaceutics, College of Pharmacy, University of Ha’il, Saudi Arabia and Department of Pharmaceutics, Faculty of Pharmacy, Zagazig University, Egypt.
Md. Khalid Anwer
Department of Pharmaceutics, College of Pharmacy, Prince Sattam Bin Abdulaziz University, Al-kharj, Saudi Arabia.
El-Sayed Khafagy
Department of Pharmaceutics, College of Pharmacy, Prince Sattam Bin Abdulaziz University, Al-kharj, Saudi Arabia and Department of Pharmaceutics, Faculty of Pharmacy, Suez Canal University, Ismailia, Egypt.
Muqtader Mohammad
Department of Pharmaceutics, College of Pharmacy, Prince Sattam Bin Abdulaziz University, Al-kharj, Saudi Arabia.
Mahmoud S. Soliman
Department of Pharmaceutics, College of Pharmacy, University of Ha’il, Saudi Arabia and Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Al-Azhar University, Cairo, Egypt.
*Author to whom correspondence should be addressed.
Abstract
The present work was aimed to develop a transferosomal gel of ibuprofen (IBU) for the amelioration of psoriasis like inflammation. Three formulation of IBU loaded transferosomes (TFs1-TFs3) were prepared using different proportions of lipid (phospholipon 90H) and surfactant (tween 80) and further evaluated for vesicle size, zeta potential (ZP), entrapment efficiency and in vitro drug release. The IBU loaded transferosomes (TFs2) was optimized with vesicle size (217±8.4 nm), PDI (0.102), ZP (-31.5±4.3 mV), entrapment efficiency (88.4±6.9%) and drug loading (44.2±2.9%). Further, the optimized IBU loaded transferosomes (TFs2) was incorporated into 1% carbopol 934 gel base and characterized for homogeneity, extrudability, viscosity and drug content. The in vivo pharmacodynamic study of gel exhibited reduction in psoriasis like inflammation in mice. The ibuprofen loaded transferosomal gel was successfully developed and has shown the potential to be a new therapy against psoriasis like inflammation.
Keywords: Ibuprofen, transferosomes, gel, psoriasis.