Therapeutic Effects of Phytochemicals of Brassicaceae for Management of Obesity
Abudukadeer Kuerban *
Department of Biochemistry, Faculty of Science, King Abdul-Aziz University (KAU), Jeddah, Kingdom of Saudi Arabia.
Soonham Sami Yaghmoor
Production of Bioproducts for Industrial Applications Research Group, King Abdul-Aziz University (KAU), Jeddah, Kingdom of Saudi Arabia and Experimental Biochemistry Unit, King Fahd Medical Research Center, King Abdul-Aziz University (KAU), Jeddah, Kingdom of Saudi Arabia.
Yaaser Q. Almulaiky
Department of Biochemistry, Faculty of Science, University of Jeddah, Jeddah, Kingdom of Saudi Arabia and Chemistry Department, Faculty of Applied Science, Taiz University, Yemen
Youssri Ahmed Mohamed
Department of Biochemistry, Faculty of Science, King Abdul-Aziz University (KAU), Jeddah, Kingdom of Saudi Arabia and Production of Bioproducts for Industrial Applications Research Group, King Abdul-Aziz University (KAU), Jeddah, Kingdom of Saudi Arabia and Microbial Biotechnology Department, Genetic Engineering and Biotechnology Research Division, National Research Center, Dokki –Cairo, Egypt.
Syed Shoeb Iqbal Razvi
Department of Biochemistry, Faculty of Science, King Abdul-Aziz University (KAU), Jeddah, Kingdom of Saudi Arabia.
Mohammed Nihal Hasan
Department of Biochemistry, Faculty of Science, King Abdul-Aziz University (KAU), Jeddah, Kingdom of Saudi Arabia.
Said Salama Moselhy
Department of Biochemistry, Faculty of Science, King Abdul-Aziz University (KAU), Jeddah, Kingdom of Saudi Arabia and Experimental Biochemistry Unit, King Fahd Medical Research Center, King Abdul-Aziz University (KAU), Jeddah, Kingdom of Saudi Arabia and Bioactive Natural Products Research Group, King Abdul-Aziz University (KAU), Jeddah, Kingdom of Saudi Arabia and Biochemistry Department, Faculty of Science, Ain Shams University, Cairo, Egypt
Ayat B. Al-Ghafari
Department of Biochemistry, Faculty of Science, King Abdul-Aziz University (KAU), Jeddah, Kingdom of Saudi Arabia
Hadeel M. Alsufiani
Department of Biochemistry, Faculty of Science, King Abdul-Aziz University (KAU), Jeddah, Kingdom of Saudi Arabia.
Taha A. Kumosani
Department of Biochemistry, Faculty of Science, King Abdul-Aziz University (KAU), Jeddah, Kingdom of Saudi Arabia and Production of Bioproducts for Industrial Applications Research Group, King Abdul-Aziz University (KAU), Jeddah, Kingdom of Saudi Arabia and Experimental Biochemistry Unit, King Fahd Medical Research Center, King Abdul-Aziz University (KAU), Jeddah, Kingdom of Saudi Arabia
Abdulrahman L-AL-Malki
Department of Biochemistry, Faculty of Science, King Abdul-Aziz University (KAU), Jeddah, Kingdom of Saudi Arabia and Experimental Biochemistry Unit, King Fahd Medical Research Center, King Abdul-Aziz University (KAU), Jeddah, Kingdom of Saudi Arabia and Bioactive Natural Products Research Group, King Abdul-Aziz University (KAU), Jeddah, Kingdom of Saudi Arabia
*Author to whom correspondence should be addressed.
Abstract
Cruciferous vegetables are rich in glucosinolates, carotenoids, chlorophylls and ascorbic acid which play a major role in the modulation of lipid metabolism and are therefore involved in the lowering of total cholesterol levels in the blood. Cruciferous diet has an inverse relationship with the obesity which has been attributed to the indoles and isothiocyanates derived from the glucosinolates, such as indole-3-carbinol (I3C) and sulforaphane. Obesity and overweight still remain one of the leading causes of “preventable” deaths worldwide exerting a great deal of strain on the healthcare systems. It is ironic to note that there are nearly 100 drugs available in the market for the obesity related diseases like hypertension, but only 6 medications have been approved for the treatment of obesity in the long run. Since obesity is a chronic and permeant disease, it puts an individual to a risk of 30 more chronic diseases like hypertension, type 2 diabetes, cancers, degenerative joint diseases and cardiovascular diseases. Hence, there is a desperate need to find an alternative supporting strategy to support the current medications. In this communication, we have explored the role of phytochemicals from cruciferous diet in exerting hypolipidemic effects, which may open up nascent avenues for therapeutic intervention to tackle obesity.
Keywords: Cruciferous, brassicaceae, hyperlipidemia, cholesterol, indole-3-carbinol, brassica, hypercholesterolemia