Open Access Original Research Article

Anti-Fungal efficacy of Probiotics in Heat Cure Dentures Base Resin: An In-vitro Study

R. Kirupa Shankar, Hemamalini Balaji, N. Shanmuganathan, N. Parthasarathy, I. Athiban, R. Thirumalaikumaran

Journal of Pharmaceutical Research International, Volume 34, Issue 49A, Page 1-6
DOI: 10.9734/jpri/2022/v34i49A36421

Aim: To assess if probiotics alter the adherence of candida species onto the denture base material made with Polymethylmethaacrylate(PMMA).

Materials and Methods: Sample number of 10 per denture base resin with Sample dimensions of length 10 mm × 10 mm and width 2 mm.

Test Group: PMMA samples coated with probiotics at varying concentrations dipped in saliva Containing candida species.

Control Group: PMMA samples in saliva containing candidal species without probiotics.

Results: Significant difference of candida cell count on PMMA was evident before and after giving probiotic. On the heat cure denture base materials, there was a significant decrease in Candidal cell counts when the probiotic concentrations (2.5, 5, 10, 15 and 20 µg/ml) increased.

Open Access Original Research Article

Prevalence, Information & Attitude towards Using Supplements among University Athletes

Sajjad Ali Gill, Umer Zahid, Uzair Abdullah, Mohammad Shaheen, Abida Naseer, Zafar Iqbal Butt, Rehan Zafar, Rana Adil, Hira Shahid, Muhammad Arslan

Journal of Pharmaceutical Research International, Volume 34, Issue 49A, Page 7-17
DOI: 10.9734/jpri/2022/v34i49A36422

The purpose of this study was to analyze the prevalence of dietary supplements usage amongst university’s players, in addition to their know-how and players towards sports supplementation. Current study check out the extent of knowledge, attitudes, beliefs and practices regarding using dietary supplements of 100 athletes was administered, which included 88 Males and 12 Females, 20 to 27 years of age from the population of university athletes. The comparison was analyzed by chi-square test to observe the importance of distinction amongst respondents’ notion about the statements of questionnaires. The results calculated through Statistical Package for Social Sciences (SPSS-25). The outcomes displayed that maximum of the athletes proven the satisfactory knowledge of dietary supplements and the motives for the usage of them; however the outcome of the study suggested that need of inclusive knowledge of players about supplements and under vigilant management showed improvement of University athletes.

Open Access Original Research Article

Factors Affecting the Uptake of Combination Therapy for the Treatment of COVID-19

Mita Restinia, Ahmad Musir, Hendri Aldrat, Hoirun Nisa, Yuli Amran, . Marvel, Alia Dening

Journal of Pharmaceutical Research International, Volume 34, Issue 49A, Page 26-36
DOI: 10.9734/jpri/2022/v34i49A36424

Aims: To analyze factors affecting the use of a combination of herbs and medication or supplements for COVID-19 treatment among self-isolation patients.

Methodology: A cross-sectional study was conducted to 268 COVID-19 patients with home self-isolation in Indonesia. Data were collected by using a google form questionnaire, consisting of closed-formatted and open-ended questions, from October 9th to December 9th, 2021. A multivariate analysis was performed using a logistic regression test.

Results: The proportion of COVID-19 patients who used a combination of herbs and medication or supplements was 78.4%. Vitamin C, vitamin D, and paracetamol were the medication and supplements most frequently taken by patients. The most commonly consumed herbs were honey (70.7%), ginger (50.18%), and turmeric (26.74%). The multivariate analysis results showed that the duration of infection, sunbathing activities, and marital status were factors significantly associated with the use of a combination of herbs and medication or supplements (P<0.05).

Conclusion: This study highlighted that most COVID-19 patients used herbs in combination with medication or supplements for their treatment. Therefore, there is a necessity for education, especially for patients and health professionals about the potential herb-drug interactions.

Open Access Original Research Article

Discriminating Benign and Malignant Brain Tumors By Spectral Analysis of Cerebrospinal Fluid

V. Masilamani, R. Vidhya Shree, Ajay T. Prasad, Kannan Ramamurthy, Chellappan Selvaraju, Wafa Mohammed Alsaleh, Tahani A. Alrebdi, Trinka Vijmasi, A. Thiruvalluvan, V. Chandramouleeswaran

Journal of Pharmaceutical Research International, Volume 34, Issue 49A, Page 37-48
DOI: 10.9734/jpri/2022/v34i49A36425

The preliminary study is concerned with an innovative technique for the discrimination of malignant brain tumor from benign with reasonable sensitivity and specificity. The entire study is based on the relative fluorescence intensity and life-time of bio-fluorophores like tryptophan and tyrosine which are then validated as a set of ratio parameters. Resultantly, it was seen that malignancy was characterized by three-fold enhancement of tyrosine. The picosecond-time resolved decay time measurement was done, which exhibited two-fold decrease in decay time for malignant sample. The improved accessibility, with minimal invasiveness to the patient, and lower cost are encouraging aspects of this technique.

Open Access Review Article

Theranostics Usage of Nano Drug Complexes in Clinical Patientcare

Taha Nazir, Saeed Ur Rashid Nazir, Humayun Riaz, Pervaiz Akhtar Shah, Misbah Sultana, Safia Sultana Munir, . Ubaidullah, Marwa M. Elmaghrabi, Umer Farooq, Ishtiaq Rabi, Nida Taha

Journal of Pharmaceutical Research International, Volume 34, Issue 49A, Page 18-25
DOI: 10.9734/jpri/2022/v34i49A36423

The extraordinary expansion in the nanomedicine with the development of new nano drug particles made surprising advancement in diagnosis and treatment. Nano drug complexes have amazing medicinal properties and clinical benefits in health care practice. That allows these to attach, absorb and deliver the nano molecule including RNA, DNA, probes and proteins at desired site in an efficient manner. Certain diagnostic agents are potential used to theranostics purpose in nano drug’s formulation. Additionally the biotransformation technique used to achieve the desired clinical results and/ or pharmacological benefits. The reproducible synthesis of monodispersed nano drug particles play efficient role in healthcare system. Thus, we aimed this study to review the theranostics usage of nano drug complexes in clinical patientcare. The current scientific information used in nano drug particles; non-invasive imaging techniques; and enhanced permeability and retention are tried to incorporate to enhance the credibility of this review article.  The medicinal potential of nano drug complexes can effectively be used with the interventions of modern technologies, image guided drug delivery system, antigen targeted immunotherapy and radio-guided drug distribution for individualized and poly-pharmacy practice.