Open Access Case Report

Bisphosphonate Induced Osteonecrosis of the Jaw in Renal Sarciodosis: A Case Report

N. S. Mamatha, J. K. Savitha, R. Narahari, Monisha Uday Hangal

Journal of Pharmaceutical Research International, Page 34-40
DOI: 10.9734/jpri/2022/v34i20B35831

The therapeutic use of Bisphosphonates has increased in the last decade. The long-term use of bisphosphonates has led to a challenging complication related to jaws knows as Bisphosphonate- induced osteoradionecrosis of the jaw BIONJ. In this paper we report a case of BIONJ in a renal sarcoidosis patient with clinical implications and management.

Open Access Original Research Article

Down Regulation in Glutathione S-Transferase Stimulate Oxidative Stress and Genetic Susceptibility of Human Breast Cancer

Asia Adil, Mahrukh Malik, Javeria Arshad Malik, Sara Nazir, Irum Sabir Ali

Journal of Pharmaceutical Research International, Page 1-15
DOI: 10.9734/jpri/2022/v34i20B35827

Glutathione S-Transferase is an enzyme that catalyzed the formation of thio-ether conjugates between the endogenous tripeptide glutathione and xenobiotic compounds. Imbalance of glutathione level is observed in a variety of disease including breast cancer. In the present study we observed the alteration in the glutathione level and variation in glutathione S-transferase enzyme supergene family to influence susceptibility to breast cancer disease. Our study include 50 breast cancer tissues sample along with 25 ANCT control. The experiments were performed through high performance liquid chromatography to determine the endogenous glutathione level and multiplex PCR was used to determine GSTM1 & GSTT1 genotypes. The relationship between breast cancer and disease progression and histological grade were estimated by one way ANOVA and descriptive statisctics followed by spearman correlation {S.D±SEM, 95% CI (P<0.05)}. The study show decreased level of glutathione (GSHt P<0.05, GSH, GSSG P>0.05) in breast cancer tissue sample when compared to control, while no significance difference was occurred in GST (P>0.05) concentration when compared to control. In addition significance difference was observed when correlated histological grades {(grade II P<0.05) gradeII & III P>0.05)} with control subjects. We therefore, also investigated the role of GST genotypes to associate the role of this genotype in breast cancer. Genotyping study of GST show that the GSTM1 (P>0.05) null genotype was significantly associated with breast cancer and we found no association with breast cancer and GSTT1 (P<0.05) null genotype. In conclusion our study suggest that the dysregulation of glutathione level were associated with breast cancer and GSTM1 null genotype could be a useful marker for breast cancer prognosis.

Open Access Original Research Article

Validated RP-HPLC Method Development for Estimation of Ertugliflozin and Sitagliptin in Bulk and Dosage Forms

B. Rajeswari, N. Saritha, N. Devanna

Journal of Pharmaceutical Research International, Page 22-26
DOI: 10.9734/jpri/2022/v34i20B35829

A simple, accurate, precise method was developed for the simultaneous estimation of the Ertugliflozin and Sitagliptin in bulk and tablet dosage form. Chromatogram was run through Std Discovery C18150 x 4.6 mm, 5m. Mobile phase containing Buffer 0.1% OPA (2.2ph): Acetonitrile taken in the ratio 60:40 was pumped through column at a flow rate of 1 ml/min. Buffer used in this method was 0.1% Ortho Phosphoric Acid (OPA). Temperature was maintained at 30°C. Optimized wavelength selected was 218 nm. Retention time of Ertugliflozin and Sitagliptin were found to be 2.228min and 2.880min. %RSD of the Ertugliflozin and Sitagliptin were and found to be 0.4 and 0.7 respectively. %Recovery was obtained as 99.23% and 100.01% for Ertugliflozin and Sitagliptin respectively. LOD, LOQ values obtained from regression equations of Ertugliflozin and Sitagliptin were 0.20, 0.61 and 0.46, 1.40 respectively. Regression equation of Ertugliflozin is y = 43997x + 2639, and y = 46501.x + 13112 of Sitagliptin. Retention times were decreased and that run time was decreased, so the method developed was simple and economical that can be adopted in regular Quality control test in Industries.  

Open Access Review Article

A Comprehensive Review of a New Nanosuspension for Improving the Oral Bioavailability of Poorly Soluble Drugs

G. Karthick, D. Akiladevi, M. Irfan Ahamed

Journal of Pharmaceutical Research International, Page 16-21
DOI: 10.9734/jpri/2022/v34i20B35828

Nanosuspension is a novel drug formulation for the delivery of hydrophobic drugs. The problem of medications that are poorly water-soluble and have low bioavailability is countered by nanosuspension technology. Solubility is a significant physiochemical element that influences drug absorption and therapeutic effectiveness. Poor aqueous solubility has the potential to impair formulation development. Nanosuspension technology can improve the drug's stability and bioavailability. Nanosuspensions can be formulated for various routes of administration such as oral, parenteral, ocular, topical, and pulmonary routes. Nanosuspension can be used for targeted drug delivery also by mucoadhesive gels and ocular inserts. Recent studies were approached to develop nanosuspension on site-specific drug delivery.

Open Access Review Article

Study of Some Herbal Formulations Available for Rheumatoid Arthritis Treatment in Indian Market

Vaishali Somani, Ashish Jain

Journal of Pharmaceutical Research International, Page 27-33
DOI: 10.9734/jpri/2022/v34i20B35830

Rheumatoid arthritis is an immune mediated inflammatory disease (IMID) of the joints, characterized by destruction of bones and joints. Genetic, hormonal, environmental and nutritional, and socio-economic, age and sex, ethnicity, smoking, infections are some risk factors of rheumatoid arthritis. The treatments which are available including steroidal and non-steroidal allopathic therapies cannot cure or prevent the disease and having severe side effects. These treatments can only provide temporary relief by suppressing and reducing the pain in the joints. Traditional medicines are prevalent in the treatment of rheumatoid arthritis due to severe side effect of allopathic medicines in many countries. Many native medicinal plant of India have effective properties on rheumatoid arthritis. In this review, marketed herbal products available in Indian market are studied. In this study, a search was done to compile marketed herbal formulation and we complied ten herbal products which are sold in Indian market by companies like Himalaya, Dabur, Patanjali, Charak etc for the treatment of rheumatoid arthritis.

Open Access Review Article

Review of Fast-dissolving Tablets - A New Era in Brand-new Drug Delivery Systems

M. Irfan Ahamed, D. Akila Devi, G. Karthick

Journal of Pharmaceutical Research International, Page 41-49
DOI: 10.9734/jpri/2022/v34i20B35832

Fast disintegrating tablets (FDTs) have received ever-increasing demand during the last decade, and the field has become a rapidly growing area in the pharmaceutical industry. Oral drug delivery remains the preferred route for administration of various drugs. Recent developments in the technology have prompted scientists to develop FDTs with improved patient compliance and convenience. Upon introduction into the mouth, these tablets dissolve or disintegrate in the mouth in the absence of additional water for easy administration of active pharmaceutical ingredients. The popularity and usefulness of the formulation resulted in development of several FDT technologies. FDTs are solid unit dosage forms, which disintegrate or dissolve rapidly in the mouth without chewing and water. FDTs, or orally disintegrating tablets, are highly helpful for children and old people who have trouble swallowing standard pills and capsules .This review focuses on lyophilization, moulding, sublimation, and compaction FDT methods, as well as efforts to enhancing FDT qualities, such as spray drying and the usage of disintegrants. Taste-masking technology, experimental disintegration time measurements, and dissolution are also addressed.