Open Access Original Research Article

Lip Prints Analysis: An Observational Study

S. Samudhrasri, V. Vishnu Priya, Abirami Arthanari, R. Gayathri, S. Kavitha, P. K. Reshma, Y. Dinesh

Journal of Pharmaceutical Research International, Page 1-9
DOI: 10.9734/jpri/2022/v34i6A35413

Aim: The aim of the present study is to determine the lip prints among undergraduate dental students.

Introduction: Human identification is a universal process based on scientific principles mainly involving fingerprinting. Uniqueness is a strong point used in the analysis of fingerprints to convince the court of law. Even the lip prints are unique for an individual and can be used for identification purposes. Thus lip prints can be used to verify the presence or absence of a person at the scene of crime. The aim of this study is to analyse lip prints among undergraduate dental students.

Materials and Methods: The study group consisted of 50 females. The materials used were lipstick, a brush for applying the lipstick, and magnifying lens. Lipstick was applied evenly on the vermilion border of the lips and the pattern was studied.

Results: This study of lip print pattern of 50 females revealed the following observation:

No two lip prints matched each other establishing the uniqueness of lip prints and type 2(branched Y shaped grooves) is most commonly seen.

Conclusion: This study showed that lip prints are unique for an individual and hold potential promise as a supplementary tool in forensic odontology.

Open Access Original Research Article

Preliminary Phytochemical, Antioxidant and Hypolipidemic Potential of Aqueous Extract of Ferula asafoetida-An in vitro Study

T. Asmidha, R. Gayathri, V. Vishnu Priya, J. Selvaraj, S. Kavitha

Journal of Pharmaceutical Research International, Page 10-18
DOI: 10.9734/jpri/2022/v34i6A35414

Aim: To analyse the preliminary phytochemical, antioxidant, anti-cholesterol potential of aqueous extract of Ferula asafoetida.

Background: Hyperlipidemia is considered as one of the leading causes behind the occurrence of deadly disorders like diabetes, cardiovascular diseases, atherosclerosis etc. It is characterised by elevated levels of plasma lipids, mainly total cholesterol. Antioxidants are compounds which can inhibit oxidative damage.  is the herbaceous plant belonging to the family Umbelliferae. It is used as spice in food and also used as digestive aid. It is used in the treatment of asthma and whooping cough and it also helps to reduce blood pressure.

Methods: Aqueous extract of Ferula asafoetida was prepared by hot percolation method. The screening of phytochemical constituents, assessment of in vitro antioxidant activity and anticholesterol activity were done using standard procedures and the data were analysed statistically using one-way analysis of variance (ONE-WAY ANOVA) and the significance was considered at the levels of p<0.05.

Results: Ferula asafoetida extract was rich in phytochemicals and possessed potent in vitro antioxidant activity. Anti-cholesterol activity of Ferula asafoetida extract was examined and it was observed   that the plant extract exhibited significant anti cholesterol potential in a dose dependent manner with an IC 50 value of 400 µg/ml.

Conclusion: The study established the in vitro antioxidant and hypolipidemic potential of aqueous extract of Ferula asafoetida.  It is concluded that the extract of Ferula asafoetida possesses potent antioxidant and anticholesterol activity.

Open Access Original Research Article

Drug Prescription Pattern in Osteoarthritis in a Tertiary Care Teaching Hospital

Riyaz A. Siddiqui, Tanaji R. Shende, Harsh V. Salankar, Sonali B. Rode

Journal of Pharmaceutical Research International, Page 19-24
DOI: 10.9734/jpri/2022/v34i6A35427

Objective: Drug prescribing studies aim to provide feedback to the prescriber and to create awareness among them about rational use of medicines. The primary aim of drug utilization research is to facilitate the rational use of drugs in patients. Osteoarthritis is the most common form of joint disease and the leading cause of pain in elderly people. The aim of the study was to study the prescription pattern of drugs used in the management of osteoarthritis.

Methods: A prospective observational study was conducted in a tertiary care hospital for period of 12 months in collaboration with the department of Orthopaedics. A total of 300 patients enrolled in the present study with fulfilling inclusion and exclusion criteria. Patients’ data was recorded in case report form and analysed to study the prescription pattern.

Results: Out of the total 300 patients enrolled in this study, Osteoarthritis was found to be more common in females. In our study 58.3% of patients were females as compared to 41.7 % of male patients. Patients of age group 46-60 years (60%) were most commonly affected followed by 61-75 years (30.3%). Etoricoxib was the most commonly used NSAID in 28.3% of patients followed by Aceclofenac in 18%, combination of Aceclofenac and Paracetamol in 15.6% & combination of Tramadol and Paracetamol in 8.3% of patients.

Conclusions: In our study it is seen that osteoarthritis affects females more often than males and the knee joint is the most commonly affected joint. Etoricoxib was the most prescribed drug because of good gastrointestinal tolerance.

Open Access Original Research Article

Effect of Brushing Simulation on the Surface Roughness of Two Different Commercially Available Glass Ionomer Cements - An In Vitro Study

Shilpa Merlyn Jose, S. Balaji Ganesh, S. Jayalakshmi

Journal of Pharmaceutical Research International, Page 25-32
DOI: 10.9734/jpri/2022/v34i6A35428

Introduction: Glass ionomer cement (GIC) is a restorative material used in dentistry which can also be used as luting cement and for fixing orthodontic appliances. The main components found in GIC are silicon, calcium, sodium and fluoride. In order to improve the toughness of the cement, speed of setting and resistance to wearing, water content of the glass-ionomer cement was replaced by water-soluble polymers or monomer systems. The aim of this study is to evaluate the effect of brushing simulation on the surface roughness of two different commercially available glass ionomer cements.

Materials and Methods: GC gold label and D Tech are commercially available glass ionomer restorative cements chosen for this present study. 5 samples were prepared from each. The samples were checked for pre-surface roughness using a stylus profilometer and then subjected to brushing. Toothbrush simulator (ZM3.8 SD Mechatronik) with minimum pressure of 3N and a fluoridated toothpaste was used for brushing. Then the post surface roughness was again checked and the results were tabulated and then statistically analyzed using SPSS software.

Results: Surface roughness was increased after brushing simulation in both GC gold label and D Tech GIC samples. This difference was statistically not significant (paired student t, p value = 0.763).

Conclusion: D-tech GIC samples had less surface roughness after brushing simulation when compared to GC Gold label samples.

Open Access Original Research Article

RP HPLC Method Development for Simultaneous Estimation of Etoricoxib and Thiocolchicoside

Anchal Sharma, Amit Chaudhary, Bhupendra Singh

Journal of Pharmaceutical Research International, Page 39-44
DOI: 10.9734/jpri/2022/v34i6A35430

A simple, specific and accurate reverse phase high performance liquid chromatography (RP-HPLC) method was developed and validated for simultaneous estimation of Etoricoxib and Thiocolchicoside in bulk and solid dosage form. Separation was achieved by Zorbax C-18 analytical column having dimension (250mm * 4.6 mm i.d 5.0 µm) using methanol and water (60:40) as mobile phase and flow rate was 0.7ml/min. The detection was carried out at 283 nm wavelength using UV detector. The total chromatographic sample time per analysis was about 14.0 minutes with thiocolchicoside eluted at retention time 3.523 min and etoricoxib eluted at retention time 9.627 min. The method was validated for accuracy, precision, specificity, rapid, reliable and reproducible. LOD and LOQ value for etoricoxib and thiocolchicoside were found to be 0.332, 0.996 ppm and 0976, 0.928 ppm respectively. Regression Equation for Etoricoxib was y = 0.006x + 0.149 and regression equation for thiocolchicoside was Y = 0.030x + 0.086. As the run time was increased the retention time was decreased, so the method is simple and economical and can be adopted by regular quality control in industries and also in research laboratories.

Open Access Original Research Article

Seroprevalence of Rubella Virus among Pregnant Women in the Red Sea Region of Sudan

Anass M. Abbas, Manar G. Shalabi, Magdi B. Muzamil, Abdulrab Ahmed M. Alkhanjaf, Hatem Mohamed, Hasan Ejaz

Journal of Pharmaceutical Research International, Page 45-51
DOI: 10.9734/jpri/2022/v34i6A34598

Aims: We aimed to investigate the occurrence of the rubella virus among pregnant women, including those who had a history of abortions in the Red Sea region of Sudan.

Study design: Cross-sectional study.

Place and Duration of Study: The study was conducted at the Port Sudan referral tertiary hospital.

Methodology: Blood samples were collected at random from 100 participants who were pregnant or had a history of abortion and who were referred to the hospital. Side flow chromatography immunoassay was used for detection, and the Elisa technique was used for confirmation.

Results: From a total of 100 participants, rubella virus Immunoglobulin G (IgG) was detected in 20 (20%), and 80 were seronegative (80%). The seronegative Immunoglobulin M (IgM) was 0 (00.0%), with no participant had a recent infection. The prevalence of 11 rubella virus IgG was significantly high (P = .003) among the females who had abortions 61 (61%). However, no statistically significant relationship was found with the frequency of IgG of rubella virus and age, gestational age, level of education, or occupation.

Conclusion: The study concluded that the prevalence of rubella infections was higher among pregnant females and who had a history of abortions in the Red Sea region. The detection of human rubella virus IgG previous infection was higher than IgG recent infection.

Open Access Review Article

Comparison of Various Diagnostic Modalities for Genital Tuberculosis in Sub-Fertile Women in Rural Hospital

Asawari Deo, Deepti Shrivastava

Journal of Pharmaceutical Research International, Page 33-38
DOI: 10.9734/jpri/2022/v34i6A35429

In India, tuberculosis of the genital tract, particularly of the Fallopian tubes and endometrium, is a leading cause of persistent infertility in women. The identification of FGTB so that therapy can begin as soon as possible is still a clinical problem. The paucibacillary character of the illness, as well as the few diagnostic assays available, make laboratory diagnosis problematic. Because of the lengthy and tough treatment, a confirmed diagnosis of tuberculosis (TB) is required to assist and urge the patient to comply. In a rural hospital, the review compares multiple diagnostic methods for genital TB in infertile women. This review includes descriptions of the condition as well as reports that are now accessible and focus on the tests and procedures required for early identification and treatment of female genital tuberculosis [FGTB].