Open Access Policy Article

Anti-infective Therapy Principles in Diseases Caused by Bacterial Biological Agents

Viorel Ordeanu, Marius Necsulescu, Lucia E. Ionescu, Diana M. Popescu, Simona N. Bicheru, Gabriela V. Dumitrescu, Radu G. Hertzog

Journal of Pharmaceutical Research International, Page 1-9
DOI: 10.9734/JPRI/2018/43754

The international situation requires the strengthening of national security measures, including CBRN field and public health. Infectious diseases, and especially infectious-contagious diseases, represent the main threat to public health and have the highest prevalence of morbidity and mortality. These are classified by the World Health Organization in first group of human diseases. The situation may be even worse concerning biological warfare (BWA) and bioterrorism agents.

The great successes of modern medicine, looking from a holistic perspective at the species level, are based on vaccination and antibiotherapy. But, lately, some serious problems arose. The antibiotics (AB), antibacterial miracle drugs, are losing their effectiveness due to the increase in antibiotic resistance (AMR) of bacteria, a phenomenon that will worsen in the future; so, we are already discussing the end of the antibiotic era and the need for new anti-infective therapy concepts. And, as if this medical catastrophe was not enough, the "anti-vaccine" movement that undermines the specific prophylaxis of infectious diseases also appeared. Moreover, in this dangerous context to public health, the threats of biological warfare and bioterrorism are outlined.

Open Access Original Research Article

Investigating the Elements of Parent-Child Relationship and Parental Satisfaction among Mothers with Breast Cancer without Breast Cancer and Comparing Them with Each Other

Fatemeh Merati Fashi, Fatemeh Ghiasi

Journal of Pharmaceutical Research International, Page 1-8
DOI: 10.9734/JPRI/2018/43007

The purpose of this study was to investigate the elements of parent parent communication patterns and parental role satisfaction among mothers with breast cancer and non-breast cancer and compare them with each other. 60 women with breast cancer and 60 women without breast cancer were selected as samples from hospitals in Tehran. They responded to parent-child communication pattern and parental role satisfaction questionnaires. Independent T-test was used to analyse the data. The results showed that there was no significant difference between the mean of mothers with and without breast cancer in terms of relationship and lack of aggressive attachment. The mean of mothers with breast cancer was higher in admission and independence, but the mean of mothers without breast cancer was higher in aggressive control. The mean of mothers without breast cancer in parental role satisfaction was significantly higher than that of mothers with breast cancer.

Open Access Original Research Article

Effects of Guided Imagery on Anxiety and Physiological Indicators in In-patients with Acute Coronary Syndrome

Jahanshir Tavakolizadeh, Mehdi Pahlavan, Mahdi Basirimoghadam, Mojtaba Kianmehr

Journal of Pharmaceutical Research International, Page 1-8
DOI: 10.9734/JPRI/2018/43592

One of the most important complaints of patients with the acute coronary syndrome (ACS) is anxiety, whose control is particularly important. The purpose of this study was to determine the effects of guided imagery on state and trait anxiety and their physiological indicators in patients with ACS. At this clinical trial selected 50 patients by convenience sampling and randomly allocated to control and experimental groups using permutation blocks. Anxiety and physiological indicators in both groups were measured using the Anxiety Inventory (STAI), a monitoring device and a checklist respectively. In addition to the routine cares for the control group, the experimental group listened to a guided imagery CD for three days, twice a day (16 minutes). The data were analyzed using paired t-test and ANOVA. Only trait anxiety was significantly reduced in the experimental group. Furthermore, there was no significant statistical difference between the two groups in terms of the mean blood pressure, heart rate and SpO2; the respiratory rate in the experimental group was however significantly less than that in the control group after the intervention. Based on these findings, GI may be useful in reducing trait anxiety and some physiological indicators in ACS patients.

Open Access Original Research Article

Satisfaction Rate of Clients of Health Houses Affiliated to Dezful University of Medical Sciences

Mostafa Ali Mehr, Hoda Kalhorpour, Vahid Shirani, Niusha Shahidi Sadeghi, Ahmad Moradi, Mehdi Zainivand

Journal of Pharmaceutical Research International, Page 1-8
DOI: 10.9734/JPRI/2018/43727

Introduction and Objectives: Satisfaction rate of clients has a significant effect in higher quality of services provided by employees. Evaluation of health and medical services is the first necessary step in providing services correctly and also satisfaction rate of clients is one of the most important factors of evaluation. This study was carried out aimed to determine the satisfaction rate of Clients with health houses affiliated to Dezful University of Medical Sciences.

Methods: In the present study, 303 people referred to health houses affiliated to Dezful University of Medical Sciences were selected through stratified sampling method and demographic characteristics of the referrals to departments, spending time for them, guidance and training, the adequacy of services, the ability and skill of employees, facilities and equipment adequacy were collected using of questionnaires and interviews from Clients or their attendants. The comments of people and questionnaire information were analyzed by SPSS software.

Results: 303 people were interviewed during two months. The mean age of the subjects was 32.33±10.27. Also, 67.3% were women and 32.7% were men. 82.5% were married, 91.74% were living in villages and 15.2 were the Clients attendants. 68.31% of Clients were satisfied with the performance of health houses at high level.

Conclusion: According to the results of this study, the performance of health houses affiliated to Dezful University of Medical Sciences was evaluated at a high level. The satisfaction rate of the Clients was at a high level, and the managers can achieve a higher level of satisfaction in the future based on the views of the recipients of service and with more planning and effort.

Open Access Original Research Article

Gestational Exposure to a Commercial Tooth Whitening Agent Containing Carbamide Peroxide Induces Locomotory Changes and Tissue Damage in Mice Newborns

Gadah I. Al-Basher

Journal of Pharmaceutical Research International, Page 1-13
DOI: 10.9734/JPRI/2018/44556

The present study evaluates the impact of gestational exposure to a commercially available tooth whitening agent in mice newborns. A total of 20 male mice and 60 female Swiss albino mice were used in the study. After mating, 30 pregnant mice were obtained which were divided into three (3) groups. Group I consisted of 6 pregnant mice which received distilled water by oral gavage from the first day of pregnancy until the 15th day after birth; Group I: included 12 pregnant mice which received 200 mg/kg body weight tooth whitening agent and Group III included 12 pregnant mice which received 500 mg/kg body weight tooth whitening agent. Locomotory behaviour, haematological parameters such as Hb, RBC and WBC counts, the antioxidant activity of brain tissue and also histopathology of spleen, liver, gastric mucosa and brain tissues of the control as well as experimental (tooth whitening agent exposed) mice newborns were studied. The locomotor activity of the tooth whitening agent exposed offspring was significantly reduced when compared to the control. Also, the exposed offspring had shown high WBC count and decreased level of antioxidants. The results of this study further confirm that gestational exposure to a tooth whitening agent induces oxidative stress and histopathological alterations in gastric mucosa and brain in experimental group.