Synthesis of Novel 3-methyl-1-(5-methyl-1,3-benzoxazol-2-yl)-1H-pyrazol-5-amine Derivatives and In-vitro Evaluation of their Antitumor and Antibacterial Activities

J. Paveendra

Department of Chemistry, Sahyadri Science College, Shivamogga-577203, India.

H. M. Vagdevi *

Sahyadri Science College, Shivamogga-577203, India.

*Author to whom correspondence should be addressed.


Benzoxazole is one of the biologically important heterocyclic compounds, which shows remarkable pharmacological activities. In this work, 3-methyl-1-(5-methyl-1,3-benzoxazol-2-yl)-1H-pyrazol-5-amine derivatives have been synthesized by using mild protocol under solvent free condition. Structures of the synthesized compounds have been confirmed through IR, 1H NMR, 13C NMR and Mass spectral methods. All the compounds were assessed for their antitumor and antibacterial activities. 6h has found remarkable activity on both antitumor and antibacterial studies and 6g and 6a exhibited promising antibacterial and antitumor activity. Simple work up technique, good yield and use of environmental-friendly reagents are of the reaching features of the present work.

Keywords: Benzoxazole, solvent free condition, antitumor, antibacterial

How to Cite

Paveendra , J. and Vagdevi , H. M. (2023) “Synthesis of Novel 3-methyl-1-(5-methyl-1,3-benzoxazol-2-yl)-1H-pyrazol-5-amine Derivatives and In-vitro Evaluation of their Antitumor and Antibacterial Activities”, Journal of Pharmaceutical Research International, 35(13), pp. 25–35. doi: 10.9734/jpri/2023/v35i137367.


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