Therapeutic Targets In Breast Cancer Signaling: A Review
Emmanuel Ifeanyi Obeagu
*
Department of Medical Laboratory Science, Imo State University, Owerri, Imo State, Nigeria.
Quratulain Babar
Department of Biochemistry, Government College University, Faisalabad, Pakistan.
C. C. N. Vincent
Department of Nursing Science, Imo State University, Owerri, Imo State, Nigeria.
Chikwendu Lawrence Udenze
Department of University Health Services, Michael Okpara University of Agriculture, Umudike, Abia State, Nigeria.
Richard Eze
Department of Medical Laboratory Science, Madonna University Elele, Rivers State, Nigeria.
Chukwuma J. Okafor
Department of Pathology and Biochemistry, State University of Zanzibar, Tanzania.
Bart I. Ifionu
Department of Chemical Pathology and Immunology, Olabisi Onabanjo University, Ogun State, Nigeria.
Augustine Amaeze Amaeze
Department of Physiotherapy, Evangel University, Akaeze, Ebonyi State, Nigeria.
Florence Ngozi Amaeze
Department of Public Health Education, Gregory University, Uturu, Abia State, Nigeria.
*Author to whom correspondence should be addressed.
Abstract
For women, the most dominant type of cancer is breast cancer and perhaps one of the most recognizedreasons of death. This is a disorder of many distinct traits, many of which are known as positive hormone receptor, human epidermal receptor-2 (HER2+), and three negative breast cancers (TNBC). Drugs that directly target and kill tumors constitute a rapidly-growing form of molecular therapy for cancer patients. Analysis reveals that stable breast tissue cells exhibit receptors which aren't usually present. As a result, it is imperative to cognize the molecular roots of breast cancer and the myriad compromised pathology-related processes and pathways to ensure progresses in early diagnosis and prevention. This study demonstrates essential cellular pathways relevant for breast cancer including improvements in cell proliferation, apoptosis, and hormone balances in breast tissues. On the basis of these notions, we consider how breast cancer is associated to the creation of potentially therapeutic interventions and predictive biomarkers.
Keywords: Breast cancer, tumor, apoptosis, cell proliferation