Hypercalcemia and Nephrocalcinosis in an Infant with Subcutaneous Fat Necrosis: A Rare but Potential Serious Clinical Condition
Journal of Pharmaceutical Research International,
Page 8-11
DOI:
10.9734/jpri/2022/v34i42B36298
Abstract
Background: Subcutaneous fat necrosis of the newborn (SCFN) is a panniculitis characterized by the presence of violaceous subcutaneous nodules and indurated plaques on the back, buttocks, proximal extremities, or cheeks. It is a self-limiting benign condition sometimes associated with hypercalcemia that can lead to serious complications such as seizures, failure to thrive and renal failure. It usually develops in full term neonates who experienced some perinatal stress. The literature shows that hypercalcemia is found in nearly 51% of infants, with 95% of the infants developing it within 60 days of onset of skin lesions.
Clinical Description: In this case, we describe a full-term female infant presented to us with failure to thrive at 2 months of age with a postnatal history of meconium aspiration syndrome. On further evaluation, child was found to have hypercalcemia, anemia and bilateral nephrocalcinosis.
Management & Outcome: The clinical findings and lab investigations were consistent with subcutaneous fat necrosis with hypercalcemia as its main complication. Child was successfully treated with oral corticosteroids.
Conclusion: Being a rare clinical condition, it is important to consider it as a differential diagnosis in infants with significant perinatal stress and hence this case report.
Keywords:
- Failure to thrive
- hypercalcemia
- nephrocalcinosis
- perinatal stress
- subcutaneous fat necrosis
How to Cite
References
Hogeling M, Meddles K, Berk DR, Bruckner AL, Shimotake TK, Cohen RS, et al. Extensive Subcutaneous Fat Necrosis of the Newborn Associated with Therapeutic Hypothermia. 2012;29(1):59–63.
Oza V, Treat J, Cook N, Tetzlaff MT, Yan A. Subcutaneous Fat Necrosis as a Complication of Whole-Body Cooling for Birth Asphyxia. Arch Dermatol. 2010;146 (8):882–885. doi:10.1001/archdermatol.2010.176
Hicks MJ, Levy ML, Alexander J, Flaitz CM. Subcutaneous fat necrosis of the newborn and hypercalcemia: Case report and review of the literature. Pediatric dermatology. 1993;10(3):271–276.
Available:https://doi.org/10.1111/j.1525-1470.1993.tb00375.x
Karochristou K, Siahanidou T, Kakourou-Tsivitanidou T, Stefanaki K, Mandyla H. Subcutaneous fat necrosis associated with severe hypocalcaemia in a neonate. J Perinatol. 2006;26(1):64–6.
Norwood-Galloway A, Lebwohl M, Phelps RG, Raucher H. Subcutaneous fat necrosis of the newborn with hypercalcemia. J Am Acad Dermatol. 1987;16(2):435–9.
Andreasen L, Henrik-Nielsen R, Dyring-Andersen B. Subcutaneous Fat Necrosis of the Newborn. JAMA dermatology; 2022. DOI:10.1001/jamadermatol.2022.1240. Advance online publication.
Available:https://doi.org/10.1001/jamadermatol.2022.1240
Edafe O, Stenton S, Cohen MC, Beasley N, Carr S. Atypical facial presentation of subcutaneous fat necrosis of the newborn. Annals of the Royal College of Surgeons of England. 2021;103(7):e234–e237.
Available:https://doi.org/10.1308/rcsann.2021.0035
Canpolat N, Özdil M, Kuruğoğlu S, Çalışkan S, Sever L. Nephrocalcinosis as a complication of subcutaneous fat necrosis of the newborn. The Turkish journal of pediatrics. 2012;54(6):667–670.
Stefanko NS, Drolet BA. Subcutaneous fat necrosis of the newborn and associated hypercalcemia: A systematic review of the literature. Pediatr Dermatol. 2019;36(1): 24–30.
Ladoyanni E, Moss C, Brown RM, Ogboli M. Subcutaneous fat necrosis in a newborn associated with asymptomatic and uncomplicated hypercalcemia. Pediatr Dermatol. 2009;26(2):217–9.
Eichenwald E c, Hansen RA, Martin CR, Stark AR. Cloherty and Stark’s Manual of neonatal care. Ed, Wolters Kluwer. 2021;8:1124.
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