Quality of Life and Psychological Distress during Cancer: A Prospective Observational Study Involving Liver Cancer Patients
Journal of Pharmaceutical Research International,
Introduction: Liver Cancer is aggressive cancer and patients are mostly screened and diagnosed when they become symptomatic at advanced. Disease severity, depression, fatigue, joint pain, and poor appetite have been reported as strong determinants of quality of life (QoL) among liver cancer patients.
Aims: The objective of the study was to assess the quality of life and depression among liver cancer patients in Pakistan.
Study Design: A descriptive cross-sectional study design was used.
Place and Duration of Study: The study was conducted in healthcare facilities of Islamabad and Rawalpindi, Pakistan between June 2020-December 2020.
Methodology: Two pre-validated questionnaires i.e. EORTC QLQ-C30 and HADS were self-administered to a sample of 100 liver cancer patients selected using a convenience sampling technique for measuring QoL and depression, respectively. After data collection, data was cleaned, coded, and entered in SPSS.
Results: The results highlighted that the lowest scores observed in the domain of symptom scale were: Nausea and Vomiting (23.72, ± 28.238), Dyspnea (25.27, ± 26.90), Constipation (26.03, ± 34.75) followed by Diarrhea (22.63, ± 28.42), whereas highest scores in the symptom scale were observed in the domain of fatigue (37.69, ± 20.06), pain (40.37, ± 18.44), insomnia (41.65, ± 32.37) and financial difficulties (60.33, ± 33.830). On the other hand, highest score on the functional scale was observed for physical functioning (64, ± 21.76) and the lowest score was observed in social functioning (53.19, ± 20.66).
Conclusion: The present study concluded that liver cancer had a negative impact on risk factors/past medical history, co-morbidities, and poor socio-economic of life across all domains along with moderate depression in liver cancer patients. Illiteracy, advanced liver cancer stage, risk factors/past medical history, co-morbidities and poor socio-economic status negatively affected functional and symptom scale. Appropriate health educational and psychological interventional programs targeting patients should be initiated to improve awareness and reduce depression among liver cancer patients.
- Liver cancer
- quality of life
- EORTC QLQ-C30
How to Cite
Li L, Knutsdottir H, Hui K, Weiss MJ, He J, Philosophe B, et al. Human primary liver cancer organoids reveal intratumor and interpatient drug response heterogeneity. JCI insight. 2019;4(2).
El–Serag HB, Rudolph KL. Hepatocellular carcinoma: epidemiology and molecular carcinogenesis. Gastroenterology. 2007;132(7):2557-76.
Gutteling J, De Man R, Busschbach J, Darlington A. Overview of research on health-related quality of life in patients with chronic liver disease. Neth J Med. 2007;65(7):227-34.
Sumskiene J, Sumskas L, Petrauskas D, Kupcinskas L. Disease-specific health-related quality of life and its determinants in liver cirrhosis patients in Lithuania. World journal of gastroenterology: WJG. 2006;12(48):7792
Younossi ZM, Boparai N, McCormick M, Price LL, Guyatt G. Assessment of utilities and health-related quality of life in patients with chronic liver disease. The American journal of gastroenterology. 2001;96(2):579-83.
Les I, Doval E, Flavià M, Jacas C, Cárdenas G, Esteban R, et al. Quality of life in cirrhosis is related to potentially treatable factors. European journal of gastroenterology & hepatology. 2010;22(2):221-7.
Hong JS, Tian J. Prevalence of anxiety and depression and their risk factors in Chinese cancer patients. Supportive care in cancer. 2014;22(2):453-9.
Butt AS, Abbas Z, Jafri W. Hepatocellular carcinoma in pakistan: where do we stand? Hepatitis monthly. 2012;12(10 HCC).
Hafeez Bhatti AB, Dar FS, Waheed A, Shafique K, Sultan F, Shah NH. Hepatocellular carcinoma in Pakistan: national trends and global perspective. Gastroenterology Research and Practice. 2016;2016.
Poelstra K, Prakash J, Beljaars L. Drug targeting to the diseased liver. Journal of controlled release. 2012; 161(2):188-97.
Sarwar S, Tarique S, Aleem A, Khan AA. Effect of adding daclatasvir in sofosbuvir-based therapy in genotype 3 hepatitis C: real-world experience in Pakistan. European journal of gastroenterology & hepatology. 2019;31(8):1035-9.
Lee PJ, Hung PJ, Lee LP. An artificial liver sinusoid with a microfluidic endothelial‐like barrier for primary hepatocyte culture. Biotechnology and bioengineering. 2007;97(5):1340-6.
Dogar IA, Haider N, Ahmad M, Naseem S, Bajwa A. Comparison of quality of life among cardiac, hepatic, cancer, and dermatological patients. JPMA-Journal of the Pakistan Medical Association. 2012;62(3):232.
Mikoshiba N, Miyashita M, Sakai T, Tateishi R, Koike K. Depressive symptoms after treatment in hepatocellular carcinoma survivors: prevalence, determinants, and impact on health‐related quality of life. Psycho‐Oncology. 2013;22(10): 2347- 53.
Lai H-L, Lin S-Y, Yeh S-H. Exploring uncertainty, quality of life and related factors in patients with liver cancer. Hu li za zhi The Journal of Nursing. 2007;54(6):41-52.
Häuser W, Holtmann G, Grandt D. Determinants of health-related quality of life in patients with chronic liver diseases. Clinical gastroenterology and hepatology. 2004;2(2):157-63.
Hatanaka K, Kudo M, Fukunaga T, Ueshima K, Chung H, Minami Y, et al. Clinical characteristics of NonBNonC-HCC: Comparison with HBV and HCV related HCC. Intervirology. 2007;50(1):24-31.
Fielding R, Wong WS. Quality of life as a predictor of cancer survival among Chinese liver and lung cancer patients. European Journal of Cancer. 2007;43(11):1723-30.
Klein J, Dawson LA, Jiang H, Kim J, Dinniwell R, Brierley J, et al. Prospective longitudinal assessment of quality of life for liver cancer patients treated with stereotactic body radiation therapy. International Journal of Radiation Oncology* Biology* Physics. 2015; 93(1):16-25.
Klein, J., Dawson, L. A., Jiang, H., Kim, J., Dinniwell, R., Brierley, J., Wong, R., Lockwood, G. & Ringash, J. 2015. Prospective Longitudinal Assessment Of Quality Of Life For Liver Cancer Patients Treated With Stereotactic Body Radiation Therapy. International Journal of Radiation Oncology* Biology* Physics, 93, 16-25.
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