An Overview of Different Methods for Aminoglycoside Residue Determination
Journal of Pharmaceutical Research International,
Aminoglycosides (AGs) are chemical substances that exist in the bacteriologic category of traditional antibiotic (AB) therapy. The importance of the determination of AG as has been described in many situations by researchers. Because of the narrow therapeutic ranges of AGs, considerable efforts have been attributed to the analysis of AGs in pharmaceutical preparations, serum, and urine specimens for therapeutic drug monitoring purposes. Residues of ABs in many different cases like environment and human food, causes a major concern, as prolonged exposure to ABs is a serious health hazard, related to both side effects of prolonged use and the risk of developing bacterial resistance to various ABs. The major challenge is finding a sensitive and reliable method to determine AGs in a complex matrix. The microbiological assay was a simple and old method for the determination of AGs. Chromatography and spectroscopy methods are the main instrumental methods for analysis that have been employed for these purposes. Biosensor based instrumental systems have been recently used to determine the AG residues in many cases. Each of these methods has its advantages and disadvantages. This review summarizes different ways (microbiological methods, instrumental methods, and biosensor) for the determination of AGs in all cases. Different databases including PubMed, Scopus, and Web of Science with the words of AGs determination and related words for antimicrobial keywords searched without time limitation.
- antibiotic residues
- antibiotic resistance
- instrumental method
- microbiological assay
How to Cite
Kummana C, Yuen K. Parenteral aminoglycoside therapy. Selection, administrationandmonitoring. Drugs. 1994;47:902-913.
Sun F, et al., 5-Methylindole Potentiates Aminoglycoside Against Gram-Positive Bacteria Including Staphylococcus aureus Persisters Under Hypoionic Conditions. Frontiers in Cellular and Infection Microbiology. 2020;10:84.
Durante-Mangoni E, et al. Do we still need the aminoglycosides? International Journal of Antimicrobial Agents. 2009;33(3):201-205.
Poulikakos P, Falagas ME. Aminoglycoside therapy in infectious diseases. Expert Opinion on Pharmacotherapy. 2013;14(12):1585-1597.
Mingeot-Leclercq M-P, Glupczynski Y, Tulkens PM. Aminoglycosides: Activity and resistance. Antimicrobial Agents and Chemotherapy. 1999;43(4):727-737.
Novelli A, et al. In vitro postantibiotic effect and postantibiotic leukocyte enhancement of tobramycin. Journal of Chemotherapy. 1995;7(4):355-362.
Becker B, Cooper MA. Aminoglycoside antibiotics in the 21st century. ACS Chemical Biology. 2013;8(1):105-115.
Stead DA. Current methodologies for the analysis of aminoglycosides. Journal of Chromatography B: Biomedical Sciences and Applications. 2000;747(1-2):69- 93.
Aronson J, Reynolds D. ABC of monitoring drug therapy. Lithium. BMJ: British Medical Journal. 1992;305(6864):1273.
Selimoglu E. Aminoglycoside-induced ototoxicity. Current Pharmaceutical Design. 2007;13(1):119-126.
McGlinchey TA, et al., A review of analytical methods for the determination of aminoglycoside and macrolide residues in food matrices. Analytica Chimica Acta. 2008;624(1):1-15.
Cheng G, et al. Antibiotic alternatives: The substitution of antibiotics in animal husbandry? Frontiers in Microbiology. 2014;5:217.
Duggal P, Sarkar M. Audiologic monitoring of multi-drug resistant tuberculosis patients on aminoglycoside treatment with long term follow-up. BMC Ear, Nose and Throat Disorders. 2007;7(1):5.
Tao L, Segil N. Early transcriptional response to aminoglycoside antibiotic suggests alternate pathways leading to apoptosis in sensory hair cells in the mouse inner ear. Frontiers in cellular neuroscience. 2015;9:190.
Dolliver HA, Gupta SC. Antibiotic losses from unprotected manure stockpiles. Journal of Environmental Quality. 2008;37(3):1238-1244.
Beović B. The issue of antimicrobial resistance in human medicine. International Journal of Food Microbiology. 2006;112(3):280-287.
Díaz-Cruz MS, Barceló D. Recent advances in LC-MS residue analysis of veterinary medicines in the terrestrial environment. TrAC Trends in Analytical Chemistry. 2007;26(6):637-646.
Farouk F, Azzazy HM, Niessen WM. Challenges in the determination of aminoglycoside antibiotics, a review. Analytica Chimica Acta. 2015;890:21-43.
Ovalles FJ, et al. Proposal for determining sulfate counter ion in amikacin sulfate formulations by Fourier-transform infrared derivative spectroscopy. Current Pharmaceutical Analysis. 2013;9(1):20-30.
Monteleone PM, et al. Amikacin Sulfate, in Analytical Profiles of Drug Substances. 1983;37-71.
Barends DM, et al. Determination of amikacin in serum by high-performance liquid chromatography with ultraviolet detection. Journal of Chromatography B: Biomedical Sciences and Applications. 1983;276(C):385-394.
Al-Majed AA. A new LC method for determination of some aminoglycoside antibiotics in dosage forms and human plasma using 7-fluoro-4-nitrobenz-2-oxa-1, 3-diazole as a fluorogenic pre-column label. Chromatographia. 2008;68(11-12):927-934.
Rizk M, et al. Fluorimetric determination of aminoglycoside antibiotics using lanthanide probe ion spectroscopy. Talanta. 1995;42(12):1849-1856.
El-Shabrawy Y. Fluorimetric determination of aminoglycoside antibiotics in pharmaceutical preparations and biological fluids. Spectroscopy Letters. 2002;35(1):99-109.
Izquierdo P, et al. Kinetic fluorimetric determination of aminoglycoside antibiotics by use of OPA and N-acetylcysteine as reagents. Fresenius' Journal of Analytical Chemistry. 1994;349(12):820-823.
Hassanzadeh J, et al. Specific fluorometric assay for direct determination of amikacin by molecularly imprinting polymer on high fluorescent g-C3N4 quantum dots. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy. 2019;214:451-458.
Zhang L, et al. Description and validation of coupling high performance liquid chromatography with resonance Rayleigh scattering in aminoglycosides determination. Analytica Chimica Acta. 2011;706(2):199-204.
Jariwala FB, et al. Rapid determination of aminoglycosides in pharmaceutical preparations by electrospray ionization mass spectrometry. Journal of Analytical Science and Technology. 2020;11(1):1-11.
Soliven A, et al. A simplified guide for charged aerosol detection of non-chromophoric compounds—Analytical method development and validation for the HPLC assay of aerosol particle size distribution for amikacin. Journal of Pharmaceutical and Biomedical Analysis. 2017;143:68-76.
Yang B, et al. Simultaneous determination of 11 aminoglycoside residues in honey, milk and pork by liquid chromatography with tandem mass spectrometry and molecularly imprinted polymer solid phase extraction. Journal of AOAC International. 2017;100(6):1869-1878.
Kaufmann A, Butcher P, Maden K. Determination of aminoglycoside residues by liquid chromatography and tandem mass spectrometry in a variety of matrices. Analytica Chimica Acta. 2012;711:46-53.
Zhang Z, et al. Synthesis of dummy-template molecularly imprinted polymer adsorbents for solid phase extraction of aminoglycosides antibiotics from environmental water samples. Talanta. 2020;208:120385.
Liu H, et al. Poly (N-acryloyl-glucosamine-co-methylenebisacrylamide)-based hydrophilic magnetic nanoparticles for the extraction of aminoglycosides in meat samples. Journal of Chromatography A. 2020;1609:460517.
Wang R, et al. Determination of aminoglycoside antibiotics by a colorimetric method based on the aggregation of gold nanoparticles. Nano. 2013;8(04):1350037.
Yola ML, Atar N, Eren T. Determination of amikacin in human plasma by molecular imprinted SPR nanosensor. Sensors and Actuators B: Chemical, 2014;198:70-76.
Yang W-C, Yu A-M, Chen H-Y. Applications of a copper microparticle-modified carbon fiber microdisk array electrode for the simultaneous determination of aminoglycoside antibiotics by capillary electrophoresis. Journal of Chromatography A. 2001;905(1-2):309-318.
Serrano JM, Silva M. Rapid and sensitive determination of aminoglycoside antibiotics in water samples using a strong cation-exchange chromatography non-derivatisation method with chemiluminescence detection. Journal of Chromatography A. 2006;1117(2):176-183.
Kobayashi S, et al. High performance liquid chromatographic determination of astromicin and piperacillin used in combination in blood samples. The Japanese Journal of Antibiotics. 1986;39(12):3156-3163.
Chen Y. HPLC-ELSD analysis of astromicin sulfate and its related substances. Chinese Journal of Pharmaceutical Analysis. 2006;26(2):218-220.
Kawamoto T, et al. Determination of sisomicin, netilmicin, astromicin and micronomicin in serum by high-performance liquid chromatography. Journal of Chromatography B: Biomedical Sciences and Applications. 1984;305:373-379.
Uematsu T, et al. A fluorescence polarization immunoassay evaluated for quantifying astromicin, a new aminoglycoside antibiotic. Clinical Chemistry. 1988;34(9):1880-1882.
Gonzalez III LS, Spencer JP. Aminoglycosides: A practical review. American Family Physician. 1998;58(8):1811.
Löffler D, Ternes TA. Analytical method for the determination of the aminoglycoside gentamicin in hospital wastewater via liquid chromatography–electrospray-tandem mass spectrometry. Journal of Chromatography A. 2003;1000(1-2):583-588.
Barends D, et al. The determination of aminoglycoside antibiotics in serum: A comparison of a high performance liquid chromatographic method with a microbiological assay. Pharmaceutisch Weekblad. 1982;4(4):104-111.
Nouws J, et al. A microbiological assay system for assessment of raw milk exceeding EU maximum residue levels. International Dairy Journal.1999;9(2):85-90.
Lourenço FR, Pinto TDJA. Comparison of three experimental designs employed in gentamicin microbiological assay through agar diffusion. Brazilian Journal of Pharmaceutical Sciences. 200945(3):559-566.
Fabre H, et al. Determination of aminoglycosides in pharmaceutical formulations - II. High-performance liquid chromatography. Journal of Pharmaceutical and Biomedical Analysis. 1989;7(12):1711-1718.
Sekkat M, et al. Determination of aminoglycosides in pharmaceutical formulations - I. Thin-layer chromatography. Journal of Pharmaceutical and Biomedical Analysis. 1989;7(7):883-892.
Hong Y-M, et al. Simultaneous analytical method for the neomycin, gentamicin residues in seafood. Journal of Applied Biological Chemistry. 2010;53(1):25-30.
FuJii Y, Kaga T, Nishimura K. Simultaneous determination of aminoglycoside residues in livestock and fishery products by phenylboronic acid solid-phase extraction and liquid chromatography–tandem mass spectrometry. Analytical Sciences. 2019;19P065.
Dasenaki ME, Michali CS, Thomaidis NS. Analysis of 76 veterinary pharmaceuticals from 13 classes including aminoglycosides in bovine muscle by hydrophilic interaction liquid chromatography–tandem mass spectrometry. Journal of Chromatography A. 2016;1452:67-80.
Kumar, P., et al., Determination of aminoglycoside residues in kidney and honey samples by hydrophilic interaction chromatography‐tandem mass spectrometry. Journal of separation science. 2012;35(20):2710-2717.
Liu SP, Hu XL, Li NB. Resonance rayleigh scattering method for the determination of aminoglycoside antibiotics with trypan blue. Analytical Letters. 2003;36(13):2805-2821.
Moreno-González D, et al. Determination of aminoglycosides in honey by capillary electrophoresis tandem mass spectrometry and extraction with molecularly imprinted polymers. Analytica Chimica Acta. 2015;891:321-328.
Bhogte CP, Patravale V, Devarajan PV. Fluorodensitometric evaluation of gentamicin from plasma and urine by high-performance thin-layer chromatography. Journal of Chromatography B: Biomedical Sciences and Applications. 1997;694(2):443-447.
Voegel PD, Baldwin RP. Evaluation of copper‐based electrodes for the analysis of aminoglycoside antibiotics by CE‐EC. Electroanalysis. 1997;9(15):1145-1151.
Wang S, et al. Development of Enzyme-Linked Immunosorbent Assay (ELISA) for the detection of neomycin residues in pig muscle, chicken muscle, egg, fish, milk and kidney. Meat Science. 2009;82(1):53-58.
Khaldeeva E, et al. Determination of gentamicin with an amperometric enzyme immunosensor. Journal of Analytical Chemistry. 2002;57(12):1097-1102.
Agrawal AK, Singh SD, Jayachandran C. Comparative pharmacokinetics and dosage regimen of amikacin in afebrile and febrile goats. Indian Journal of Pharmacology. 2002;34(5):356-360.
Vogel R, DeFillipo K, Reif V. Determination of isepamicin sulfate and related compounds by high performance liquid chromatography using evaporative light scattering detection. Journal of Pharmaceutical and Biomedical Analysis. 2001;24(3):405-412.
Maloney JA, Awni WM. High-performance liquid chromatographic determination of isepamicin in plasma, urine and dialysate. Journal of Chromatography B: Biomedical Sciences and Applications. 1990;526:487-496.
Hosokawa S, et al. Determination of isepamicin in human plasma by HPLC with fluorescence detection after derivatization using 6-aminoquinolyl-N-hydroxysuccinimidyl-carbamate. Biological and Pharmaceutical Bulletin. 2008;31(10):1866-1869.
Tang J, et al. High Performance Liquid Chromatography (HPLC) method coupled with resonance Rayleigh scattering detection for the determination of isepamicin. Analytical Methods. 2012;4(6):1833-1837.
Lin Y-F, Wang Y-C, Chang SY. Capillary electrophoresis of aminoglycosides with argon-ion laser-induced fluorescence detection. Journal of Chromatography A. 2008;1188(2):331-333.
Acaroz U, et al. Determination of kanamycin residue in anatolian buffalo Milk by LC-MS/MS. Kafkas Üniversitesi Veteriner Fakültesi Dergisi. 2020;26(1).
Yin Z, et al. Multi-residue determination of 210 drugs in pork by ultra-high-performance liquid chromatography–tandem mass spectrometry. Journal of Chromatography A. 2016;1463:49-59.
Xu Y, et al. Colorimetric detection of kanamycin based on analyte-protected silver nanoparticles and aptamer-selective sensing mechanism. Analytica Chimica Acta. 2015;891:298-303.
Wang C, et al. Kanamycin detection based on the catalytic ability enhancement of gold nanoparticles. Biosensors and Bioelectronics. 2017;91:262-267.
Abedalwafa MA, et al. An aptasensor strip-based colorimetric determination method for kanamycin using cellulose acetate nanofibers decorated DNA–gold nanoparticle bioconjugates. Microchimica Acta. 2020;187:1-9.
Saratale GD, et al. Chlortetracycline-Functionalized silver nanoparticles as a colorimetric probe for aminoglycosides: Ultrasensitive determination of kanamycin and streptomycin. Nanomaterials. 2020;10(5):997.
Toloza CA, et al. Kanamycin detection at graphene quantum dot-decorated gold nanoparticles in organized medium after solid-phase extraction using an aminoglycoside imprinted polymer. Methods X. 2018;5:1605-1612.
Clarot I, et al. Analysis of neomycin sulfate and framycetin sulfate by high-performance liquid chromatography using evaporative light scattering detection. Journal of Chromatography A. 2005;1087(1-2):236-244.
Wang J, et al. Urea-formaldehyde monolithic column for hydrophilic in-tube solid-phase microextraction of aminoglycosides. Journal of Chromatography A. 2017;1485:24-31.
De-los-Santos-Álvarez N, et al. Modified-RNA aptamer-based sensor for competitive impedimetric assay of neomycin B. Journal of the American Chemical Society. 2007;129(13):3808-3809.
Zhang Y, Zuo P, Ye B-C. A low-cost and simple paper-based microfluidic device for simultaneous multiplex determination of different types of chemical contaminants in food. Biosensors and Bioelectronics. 2015;68:14-19.
Broughton A, Strong JE, Bodey GP. Radioimmunoassay of sisomicin. Antimicrobial Agents and Chemotherapy. 1976;9(2):247-250.
Matsunaga H, et al. An on-line clean-up procedure for large sample volume analysis of serum aminoglycoside antibiotics by reversed-phase high-performance liquid chromatography. Chemical and Pharmaceutical Bulletin. 1988;36(4):1565-1570.
Comroe Jr JH. Pay dirt: The story of streptomycin: Part I. From Waksman to Waksman. American Review of Respiratory Disease. 1978;117(4):773-781.
Wang Z, et al. Development of a simple and rapid HPLC‐MS/MS method for quantification of streptomycin in mice and its application to plasma pharmacokinetic studies. Biomedical Chromatography. 2019;33(2):e4408.
Schatz A, Bugle E, Waksman SA. Streptomycin, a substance exhibiting antibiotic activity against gram-positive and gram-negative bacteria.∗. Proceedings of the Society for Experimental Biology and Medicine. 1944;55(1):66-69.
Goetting V, Lee K, Tell LA. Pharmacokinetics of veterinary drugs in laying hens and residues in eggs: a review of the literature. Journal of Veterinary Pharmacology and Therapeutics. 201134(6):521-556.
Park S-I, et al. Pharmacokinetics of second-line antituberculosis drugs after multiple administrations in healthy volunteers. Antimicrobial Agents and Chemotherapy. 2015;59(8):4429-4435.
Han M, et al. Method for simultaneous analysis of nine second-line anti-tuberculosis drugs using UPLC-MS/MS. Journal of Antimicrobial Chemotherapy. 2013;68(9):2066-2073.
Kim H-J, et al. Simple and accurate quantitative analysis of 20 anti-tuberculosis drugs in human plasma using liquid chromatography–electrospray ionization–tandem mass spectrometry. Journal of pharmaceutical and biomedical analysis. 2015;102:9-16.
Granja RH, et al. Determination of streptomycin residues in honey by liquid chromatography–tandem mass spectrometry. Analytica Chimica Acta. 2009;637(1-2):64-67.
Vinas P, Balsalobre N, Hernández-Córdoba M. Liquid chromatography on an amide stationary phase with post-column derivatization and fluorimetric detection for the determination of streptomycin and dihydrostreptomycin in foods. Talanta. 2007;72(2):808-812.
Soheili V, et al. Colorimetric and ratiometric aggregation assay for streptomycin using gold nanoparticles and a new and highly specific aptamer. Microchimica Acta. 2016;183(5):1687-1697.
Emrani AS, et al. Colorimetric and fluorescence quenching aptasensors for detection of streptomycin in blood serum and milk based on double-stranded DNA and gold nanoparticles. Food Chemistry. 2016190:115-121.
Song E, et al. Multi-color quantum dot-based fluorescence immunoassay array for simultaneous visual detection of multiple antibiotic residues in milk. Biosensors and Bioelectronics. 2015;72:320-325.
Berrada H, et al. Determination of aminoglycoside and macrolide antibiotics in meat by pressurized liquid extraction and LC‐ESI‐MS. Journal of Separation Science. 2010;33(4‐5):522-529.
Reynolds A, Hamilton-Miller J, Brumfitt W. Newer aminoglycosides—amikacin and tobramycin: An in-vitro comparison with kanamycin and gentamicin. Br Med J. 1974;3(5934):778-780.
Dienstag J, Neu HC. In vitro studies of tobramycin, an aminoglycoside antibiotic. Antimicrobial Agents and Chemotherapy. 1972;1(1):41-45.
Lamb JW, Mann JM, Simmons RJ. Factors influencing the microbiological assay of tobramycin. Antimicrobial Agents and Chemotherapy. 1972;1(4):323-328.
Lode H, Kemmerich B, Koeppe P. Comparative clinical pharmacology of gentamicin, sisomicin, and tobramycin. Antimicrobial Agents and Chemotherapy. 1975;8(4):396-401.
Hubenov H, et al. Pharmacokinetic studies on tobramycin in horses. Journal of Veterinary Pharmacology and Therapeutics. 2007;30(4):353-357.
Jiang L, et al. Saccharide-RNA recognition in an aminoglycoside antibiotic-RNA aptamer complex. Chemistry and Biology. 1997;4(1):35-50.
El-Kosasy AM. Potentiometric assessment of Gram-negative bacterial permeabilization of tobramycin. Journal of Pharmaceutical and Biomedical Analysis. 2006;42(3):389-394.
González-Fernández E, et al. Impedimetric aptasensor for tobramycin detection in human serum. Biosensors and Bioelectronics. 2011;26(5):2354-2360.
Hadi M, Mollaei T. Reduced graphene oxide/graphene oxide hybrid-modified electrode for electrochemical sensing of tobramycin. Chemical Papers. 2019;73(2):291-299.
Santos HS, et al, Selective determination of tobramycin in the presence of streptomycin through the visible light effect on surface plasmon resonance of gold nanoparticles. Microchemical Journal. 2014;116:206-215.
Rezaei H, et al. A colorimetric nanoprobe based on dynamic aggregation of SDS-capped silver nanoparticles for tobramycin determination in exhaled breath condensate. Microchimica Acta. 2020;187(3):1-9.
Mabrouk MM, et al. Simple spectrofluorimetric methods for determination of veterinary antibiotic drug (apramycin sulfate) in pharmaceutical preparations and milk samples. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy. 2020;224:117395.
Elrod L, et al. Determination of fortimicin A and 3-O-demethylfortimicin A as 3, 5-dinitrobenzoyl derivatives by reverse-phase high-performance liquid chromatography. Analytical Chemistry. 1984;56(11):1786-1790.
Pastore P, Gallina A, Magno F. Description and validation of an analytical method for the determination of paromomycin sulfate in medicated animal feeds. Analyst. 2000;125(11):1955-1958.
Liu Y, et al. Development and validation of a liquid chromatography method for the analysis of paromomycin sulfate and its impurities. J Anal Bioanal Techniques. 2010;1(102):2.
Wang J, et al. Determination of vertilmicin sulfate and its related substances by HPLC—ELSD and HPLC—MS2. Journal of Chromatographic Science. 2006;44(9):529-534.
Wang J, Hu X. Determination of arbekacin sulfate injection and its related substances by HPLC using evaporative light scattering detection. Journal of Liquid Chromatography and Related Technologies. 2010;33(4):441-451.
Abstract View: 0 times
PDF Download: 0 times