Evaluation of Lympho-vascular Invasion in Breast Carcinoma Using Lymphatic Endothelial Marker (D2-40)
Journal of Pharmaceutical Research International,
Page 18-34
DOI:
10.9734/jpri/2021/v33i21B31375
Abstract
Breast cancer has become the most frequently diagnosed cancer and the leading cause of cancer-related death among women worldwide, overtaking lung cancer. The Present study attempts to investigate the use of D2 -40 for the detection of lympho- vascular invasion in node negative breast cancer. Additionally the lympho-vascular invasion using D2 -40 and its association with distant metastasis and overall prognosis of the patient was also explored.
Keywords:
- Vascular invasion
- microscopy
- LVD
- D2-40
- prognosis
- adenocarcinomas and tumours.
How to Cite
Dam, M., Ganapathy, H., & Lilly, S. M. (2021). Evaluation of Lympho-vascular Invasion in Breast Carcinoma Using Lymphatic Endothelial Marker (D2-40). Journal of Pharmaceutical Research International, 33(21B), 18-34. https://doi.org/10.9734/jpri/2021/v33i21B31375
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Kumar V, Abbas AK, Fausto N, Aster JC. Robbins and cotran pathologic basis of disease.
Allred DC, Harvey JM, Berardo M, Clark GM. Prognostic and predictive factors in breast cancer by immunohistochemical analysis. Modern pathology: an official journal of the United States and Canadian Academy of Pathology, Inc. 1998;11(2):155-68.
da Costa Vieira RA, Biller G, Uemura G, Ruiz CA, Curado MP. Breast cancer screening in developing countries. Clinics. 2017;72(4):244-53.
Eble JN, Tavassoli FA, Devilee P, editors. Pathology and genetics of tumours of the breast and female genital organs. Iarc; 2003.
Seidal T, Balaton AJ, Battifora H. Interpretation and quantification of immunostains. The American journal of surgical pathology. 2001;25(9):1204-7.
Harris JR, Lippman ME, Osborne CK, Morrow M. Diseases of the breast. Lippincott Williams & Wilkins; 2012.
Bland KI, Copeland EM, Gradishar WJ, Klimberg VS, editors. The breast: Comprehensive management of benign and malignant diseases. Philadelphia London Toronto Montreal Sydney Tokyo: Saunders; 1991.
Fisher B, Anderson SJ. The breast cancer alternative hypothesis: is there evidence to justify replacing it?. Journal of Clinical Oncology. 2009;28(3):366-74.
Ramsay DT, Kent JC, Hartmann RA, Hartmann PE. Anatomy of the lactating human breast redefined with ultrasound imaging. Journal of anatomy. 2005;206(6):525-34.
Houlston RS, McCarter E, Parbhoo S, Scurr JH, Slack J. Family history and risk of breast cancer. Journal of medical genetics. 1992;29(3):154-7.
Gray H, Standring S, Ellis H. Gray's anatomy. 40th ed. Edinburgh: Elsevier Churchill Livingstone; 2008;929-32.
Burkitt HG, Young B, Heath JW. Wheater's functional histology: A text and colour atlas. Edinburgh: Churchill Livingstone; 1993.
Guyton AC, Hall JE. Transport of oxygen and carbon dioxide in blood and tissue fluids. Textbook of medical physiology. 2006;502.
Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A. Global cancer statistics 2018: Globocan estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA: a cancer journal for clinicians; 2018.
Malvia S, Bagadi SA, Dubey US, Saxena S. Epidemiology of breast cancer in Indian women. Asia‐ Pacific Journal of Clinical Oncology. 2017;13(4):289-95.
Anonymous. Three year report of population based cancer registries 2012–2014. Indian Council of Medical Research (ICMR), Bangalore, India; 2016.
Kumar V, Abbas AK, Fausto N, Aster JR. Cotran pathologic basis of disease. 2015. Saunders Elsevier, 9th ed. P. 2015;1043-71.
Kumar V, Abbas AK, Fausto N, Aster JC. Robbins and cotran pathologic basis of disease. 2015. Saunders Elsevier, 9th ed. 2015;1051-68.
Rosai J, Ackerman L. Rosai and Ackerman's surgical pathology. 10th ed.Edinburgh: Mosby Elsevier. 2011;1681-1718.
Amin MB, Edge S, Greene F, et al Editors. AJCC cancer staging manual.8th ed. Springer International Publishing. 2017;17(6):1471-4.
Galea MH, Blamey RW, Elston CE, Ellis IO. The nottingham prognostic index in primary breast cancer. breast cancer research and treatment. 1992;22(3):207-19.
Weidner N. Intratumormicrovessel density as a prognostic factor in cancer. The American journal of pathology. 1995;147(1):9.
Rosen PP. Tumor emboli in intramammary lymphatics in breast carcinoma: Pathologic criteria for diagnosis and clinical significance. Pathology annual. 1983;18:215.
Dam M, Ganapathy H. Association of lympho-vascular Invasion with various known prognostic markers in breast carcinomna. Journal of Pharmaceutical Research International. 2020;132-42.
Forman D, Ferlay J, Stewart BW, Wild CP. The global and regional burden of cancer. World cancer report. 2014;2014:16-54.
Weigelt B, Peterse JL, Van't Veer LJ. Breast cancer metastasis: Markers and models. Nature reviews cancer. 2005;5(8):591.
Engers R, Gabbert HE. Mechanisms of tumor metastasis: Cell biological aspects and clinical implications. Journal of cancer research and clinical oncology. 2000;126(12):682-92.
Ito M, Moriya T, Ishida T, Usami S, Kasajima A, Sasano H, Ohuchi N. Significance of pathological evaluation for lymphatic vessel invasion in invasive breast cancer. Breast cancer. 2007;14(4):381-7.
Cunnick GH, Jiang WG, Douglas-Jones T, Watkins G, Gomez KF, Morgan MJ, et al. Lymph angiogenesis lymph node metastasisin breast cancer.Molecular cancer. 2008;7(1):23.
Gill PG, Luke CG, Roder DM. Clinical and pathological factors predictive of lymph node status in women with screen-detected breast cancer. The Breast. 2006;15(5):640-8.
Aitken E, Osman M. Factors affecting nodal status in invasive breast cancer: A retrospective analysis of 623 patients. The breast journal. 2010;16(3):271-8.
Rivadeneira DE, Simmons RM, Christos PJ, Hanna K, Daly JM, Osborne MP. Predictive factors associated with axillary lymph node metastases in T1a and T1b breast carcinomas: Analysis in more than 900 patients22. Journal of the American College of Surgeons. 2000;191(1):1-6.
Liu YL, Saraf A, Lee SM, Zhong X, Hibshoosh H, Kalinsky K, Connolly EP. Lymphovascular invasion is an independent predictor of survival in breast cancer after neoadjuvant chemotherapy. Breast cancer research and treatment. 2016;157(3):555-64.
Lee JA, Bae JW, Woo SU, Kim H, Kim CH. D2-40, podoplanin, and CD31 as a prognostic predictor in invasive ductal carcinomas of the breast. Journal of breast cancer. 2011;14(2):104 -11.
Tezuka K, Onoda N, Takashima T, Takagaki K, Ishikawa T, Wakasa T, et al. Prognostic significance of lymphovascular invasion diagnosed by lymphatic endothelium immunostaining in breast cancer patients. Oncology reports. 2007;17(5):997.
Krishnamurthy J, Kumar PS. Significance of prognostic indicators in infiltrating duct carcinoma breast: Scenar io in developing country. Indian journal of cancer. 2016;53(1):34.
Widodo I, Ferronika P, Harijadi A, Triningsih FX, Utoro T, Soeripto S. Clinicopathological significance of lymphangiogenesis and tumor lymphovascular invasion in Indonesian breast cancers. Asian Pacific Journal of Cancer Prevention. 2013;14(2):997-1001.
Gujam FJ, McMillan DC, Mohammed ZM, Edwards J, Going JJ. The relationship between tumour budding, the tumour microenvironment and survival in patients with invasive ductal breast cancer. British journal of cancer. 2015;113(7):1066.
Agarwal S, Singh A, Bagga PK. Immunohistochemical evaluation of lymphovascular invasion in carcinoma breast with CD34 and D2 -40 and its correlation with other prognostic markers. Indian Journal of Pathology and Microbiology. 2018;61(1):39.
Guleria P, Srinivas V, Basannar D, Dutta V. Comparison of lymphangiogenesis, lymphatic invasion, and axillary lymph node metastasis in breast carcinoma. Indian Journal of Pathology and Microbiology. 2018;61(2):176.
Wang J, Guo Y, Wang B, Bi J, Li K, Liang X, Chu H, Jiang H. Lymphatic microvessel density and vascular endothelial growth factor-C and-D as prognostic factors in breast cancer: A systematic review and meta-analysis of the literature. Molecular biology reports. 2012;39(12):11153-65.
Nakamura Y, Yasuoka H, Tsujimoto M, Imabun S, Nakahara M, Nakao K, et al. Lymph vessel density correlates with nodal status, VEGF-C expression, and prognosis in breast cancer. Breast cancer research and treatment. 2005;91(2):125-32.
Ansari MA, Pandey V, Srivastava V, Kumar M, Mishra RN, Kumar A. Lymphangiogenesis as a prognostic marker in breast cancer using D2 -40 as lymphatic endothelial marker—a preliminary study. Journal of Cancer Therapy. 2012;3(05):814.
Schoppmann SF, Bayer G, Aumayr K, Taucher S, Geleff S, Rudas M, et al. Prognostic value of lymphangiogenesis and lymphovascular invasion in invasive breast cancer. Annals of surgery. 2004;240(2):306.
Kumar V, Abbas AK, Fausto N, Aster JC. Robbins and cotran pathologic basis of disease.
Allred DC, Harvey JM, Berardo M, Clark GM. Prognostic and predictive factors in breast cancer by immunohistochemical analysis. Modern pathology: an official journal of the United States and Canadian Academy of Pathology, Inc. 1998;11(2):155-68.
da Costa Vieira RA, Biller G, Uemura G, Ruiz CA, Curado MP. Breast cancer screening in developing countries. Clinics. 2017;72(4):244-53.
Eble JN, Tavassoli FA, Devilee P, editors. Pathology and genetics of tumours of the breast and female genital organs. Iarc; 2003.
Seidal T, Balaton AJ, Battifora H. Interpretation and quantification of immunostains. The American journal of surgical pathology. 2001;25(9):1204-7.
Harris JR, Lippman ME, Osborne CK, Morrow M. Diseases of the breast. Lippincott Williams & Wilkins; 2012.
Bland KI, Copeland EM, Gradishar WJ, Klimberg VS, editors. The breast: Comprehensive management of benign and malignant diseases. Philadelphia London Toronto Montreal Sydney Tokyo: Saunders; 1991.
Fisher B, Anderson SJ. The breast cancer alternative hypothesis: is there evidence to justify replacing it?. Journal of Clinical Oncology. 2009;28(3):366-74.
Ramsay DT, Kent JC, Hartmann RA, Hartmann PE. Anatomy of the lactating human breast redefined with ultrasound imaging. Journal of anatomy. 2005;206(6):525-34.
Houlston RS, McCarter E, Parbhoo S, Scurr JH, Slack J. Family history and risk of breast cancer. Journal of medical genetics. 1992;29(3):154-7.
Gray H, Standring S, Ellis H. Gray's anatomy. 40th ed. Edinburgh: Elsevier Churchill Livingstone; 2008;929-32.
Burkitt HG, Young B, Heath JW. Wheater's functional histology: A text and colour atlas. Edinburgh: Churchill Livingstone; 1993.
Guyton AC, Hall JE. Transport of oxygen and carbon dioxide in blood and tissue fluids. Textbook of medical physiology. 2006;502.
Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A. Global cancer statistics 2018: Globocan estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA: a cancer journal for clinicians; 2018.
Malvia S, Bagadi SA, Dubey US, Saxena S. Epidemiology of breast cancer in Indian women. Asia‐ Pacific Journal of Clinical Oncology. 2017;13(4):289-95.
Anonymous. Three year report of population based cancer registries 2012–2014. Indian Council of Medical Research (ICMR), Bangalore, India; 2016.
Kumar V, Abbas AK, Fausto N, Aster JR. Cotran pathologic basis of disease. 2015. Saunders Elsevier, 9th ed. P. 2015;1043-71.
Kumar V, Abbas AK, Fausto N, Aster JC. Robbins and cotran pathologic basis of disease. 2015. Saunders Elsevier, 9th ed. 2015;1051-68.
Rosai J, Ackerman L. Rosai and Ackerman's surgical pathology. 10th ed.Edinburgh: Mosby Elsevier. 2011;1681-1718.
Amin MB, Edge S, Greene F, et al Editors. AJCC cancer staging manual.8th ed. Springer International Publishing. 2017;17(6):1471-4.
Galea MH, Blamey RW, Elston CE, Ellis IO. The nottingham prognostic index in primary breast cancer. breast cancer research and treatment. 1992;22(3):207-19.
Weidner N. Intratumormicrovessel density as a prognostic factor in cancer. The American journal of pathology. 1995;147(1):9.
Rosen PP. Tumor emboli in intramammary lymphatics in breast carcinoma: Pathologic criteria for diagnosis and clinical significance. Pathology annual. 1983;18:215.
Dam M, Ganapathy H. Association of lympho-vascular Invasion with various known prognostic markers in breast carcinomna. Journal of Pharmaceutical Research International. 2020;132-42.
Forman D, Ferlay J, Stewart BW, Wild CP. The global and regional burden of cancer. World cancer report. 2014;2014:16-54.
Weigelt B, Peterse JL, Van't Veer LJ. Breast cancer metastasis: Markers and models. Nature reviews cancer. 2005;5(8):591.
Engers R, Gabbert HE. Mechanisms of tumor metastasis: Cell biological aspects and clinical implications. Journal of cancer research and clinical oncology. 2000;126(12):682-92.
Ito M, Moriya T, Ishida T, Usami S, Kasajima A, Sasano H, Ohuchi N. Significance of pathological evaluation for lymphatic vessel invasion in invasive breast cancer. Breast cancer. 2007;14(4):381-7.
Cunnick GH, Jiang WG, Douglas-Jones T, Watkins G, Gomez KF, Morgan MJ, et al. Lymph angiogenesis lymph node metastasisin breast cancer.Molecular cancer. 2008;7(1):23.
Gill PG, Luke CG, Roder DM. Clinical and pathological factors predictive of lymph node status in women with screen-detected breast cancer. The Breast. 2006;15(5):640-8.
Aitken E, Osman M. Factors affecting nodal status in invasive breast cancer: A retrospective analysis of 623 patients. The breast journal. 2010;16(3):271-8.
Rivadeneira DE, Simmons RM, Christos PJ, Hanna K, Daly JM, Osborne MP. Predictive factors associated with axillary lymph node metastases in T1a and T1b breast carcinomas: Analysis in more than 900 patients22. Journal of the American College of Surgeons. 2000;191(1):1-6.
Liu YL, Saraf A, Lee SM, Zhong X, Hibshoosh H, Kalinsky K, Connolly EP. Lymphovascular invasion is an independent predictor of survival in breast cancer after neoadjuvant chemotherapy. Breast cancer research and treatment. 2016;157(3):555-64.
Lee JA, Bae JW, Woo SU, Kim H, Kim CH. D2-40, podoplanin, and CD31 as a prognostic predictor in invasive ductal carcinomas of the breast. Journal of breast cancer. 2011;14(2):104 -11.
Tezuka K, Onoda N, Takashima T, Takagaki K, Ishikawa T, Wakasa T, et al. Prognostic significance of lymphovascular invasion diagnosed by lymphatic endothelium immunostaining in breast cancer patients. Oncology reports. 2007;17(5):997.
Krishnamurthy J, Kumar PS. Significance of prognostic indicators in infiltrating duct carcinoma breast: Scenar io in developing country. Indian journal of cancer. 2016;53(1):34.
Widodo I, Ferronika P, Harijadi A, Triningsih FX, Utoro T, Soeripto S. Clinicopathological significance of lymphangiogenesis and tumor lymphovascular invasion in Indonesian breast cancers. Asian Pacific Journal of Cancer Prevention. 2013;14(2):997-1001.
Gujam FJ, McMillan DC, Mohammed ZM, Edwards J, Going JJ. The relationship between tumour budding, the tumour microenvironment and survival in patients with invasive ductal breast cancer. British journal of cancer. 2015;113(7):1066.
Agarwal S, Singh A, Bagga PK. Immunohistochemical evaluation of lymphovascular invasion in carcinoma breast with CD34 and D2 -40 and its correlation with other prognostic markers. Indian Journal of Pathology and Microbiology. 2018;61(1):39.
Guleria P, Srinivas V, Basannar D, Dutta V. Comparison of lymphangiogenesis, lymphatic invasion, and axillary lymph node metastasis in breast carcinoma. Indian Journal of Pathology and Microbiology. 2018;61(2):176.
Wang J, Guo Y, Wang B, Bi J, Li K, Liang X, Chu H, Jiang H. Lymphatic microvessel density and vascular endothelial growth factor-C and-D as prognostic factors in breast cancer: A systematic review and meta-analysis of the literature. Molecular biology reports. 2012;39(12):11153-65.
Nakamura Y, Yasuoka H, Tsujimoto M, Imabun S, Nakahara M, Nakao K, et al. Lymph vessel density correlates with nodal status, VEGF-C expression, and prognosis in breast cancer. Breast cancer research and treatment. 2005;91(2):125-32.
Ansari MA, Pandey V, Srivastava V, Kumar M, Mishra RN, Kumar A. Lymphangiogenesis as a prognostic marker in breast cancer using D2 -40 as lymphatic endothelial marker—a preliminary study. Journal of Cancer Therapy. 2012;3(05):814.
Schoppmann SF, Bayer G, Aumayr K, Taucher S, Geleff S, Rudas M, et al. Prognostic value of lymphangiogenesis and lymphovascular invasion in invasive breast cancer. Annals of surgery. 2004;240(2):306.
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