Bio Active Compound Analysis of Croton scabiosus Bedd: By HPTLC, GC-MS and Evaluation of Anthelmintic Activity and Anticancer Potential on Lung (A549) and Breast (MCF-7) Cancer Cell Lines
Journal of Pharmaceutical Research International,
Page 45-53
DOI:
10.9734/jpri/2021/v33i331159
Abstract
Croton scabiosus Bedd. (Euphorbiaceae) is an endemic plant of Andhra Pradesh, India. Local communities use the verdant parts of this plant as an antidote to treat snake bites and as a remedy to heal leucorrhoea in the form of decoction. In the present study the author found to have a perceptible range of alkaloids, coumarins, glycosides, flavonoids, steroids and gallic tannins as secondary metabolites by phytochemical and spectral studies. Since flavonoids and alkaloids are known for remarkable anticancer and anthelmintic activities respectively, the researcher is interested to document the research findings on these activities.The present research is aimed to evaluate bioactive principles present in acetone, chloroform and ethyl acetate extracts of Croton scabiosus Bedd. by chemical tests and spectral analysis. It is also aimed to study the anthelmintic and anticancer potential of these extracts.Acetone, chloroform and ethyl acetate extracts of Croton scabiosus Bedd. were prepared by triple maceration technique. GC-MS and HPTLC analysis were performed to identify chemical constituents. Anthelmintic and anticancer potential was assessed for the three extracts. Owing to the positive results of chemical constituents, the researcher made an attempt to evaluate anthelmintic, cytotoxic potential and anticancer activity on breast adenocarcinoma cells (MCF-7) and lung adenocarcinoma cell line (A549). It was pointed to appraise Croton scabiosus Bedd. extracts have considerable Anthelmintic, cytotoxic and anticancer potential.
Keywords:
- Anthelmintic
- breast adenocarcinoma cells (MCF-7)
- Croton scabiosus Bedd
- cytotoxic potential
- lung adenocarcinoma cell line (A549).
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References
Freddie Bray, Jacques Ferlay ME, Isabelle Soerjomataram MD, Rebecca L Siegel. Global Cancer Statistics: Globocan Estimates of Incidence and Mortality worldwide for 36 Cancers in 185 Countries. CA Cancer J Clin. 2018; 68:394-424.
Shu-Yi Yin, Wen-Chi Wei, Feng-Yin Jian, Ning-Sun Yang. Therapeutic applications of Herbal Medicines for Cancer Patients.J Evi Based Complement Altern Med. 2013; 1-15.
Available:http://dx.doi.org/10.1155/2013/302426.
Salamma S, Ravi Prasad Rao B. In vitro propagation of croton scabiosusBedd. (Euphorbiaceae), an endemic and vulnerable tree species. J Advbiotechnol. 2014;3(3):13.
Venkataratnam K, Venkataraju R. Folk medicine used for common women allignments by Adivasis in the eastern ghats of Andhra Pradesh Indian J tradit know. 2005;4(3):267-270.
Padma Y, Sarojinidevi N, VenkaRatnam G, Tirupati Reddy. Herbal/Folk remedies used for Snake bites by tribals/rural people of Rayalaseema region, Andhra Pradesh, India. J Med Plants Stud. 2016;4(2):52-56.
Peter Masoko. Phytochemical Analysis, Antioxidant and Antibacterial Properties of Spilanthesmauritiana used traditionally in Limpopo Province, South Africa. J Evi Based Complement Altern Med. 2017; 22(4):936–943.
Sarojini Devi N, Mani J, Venkata Raju RR. In vitro antimicrobial activity and phytochemical constituents of Croton scabiosus Bedd. Int J Pharm Res Dev. 2011;3(6):149-154.
Raman Preet, Raghbir Chand Gupta. HPTLC Analysis of Solanumx anthocarpum Schrad. And Wendl., A Siddha Medicinal Herb. Adv Pharmacol Sci. 2018;1-6.
Available:https://doi.org/10.1155/2018/8546306
Jitendra Patel, Venkateshwar Reddy, Kumar GS, Satyasai. Gas chromatography and mass spectroscopy analysis of bioactive components on the leaf extract of Terminaliacoriacea: A potential folklore medicinal plant. Int J Green Pharm. 2017;11(1): S140.
Das SS, Monalisha Dey, Ghosh AK. Determination of Anthelmintic Activity of the Leaf and Bark Extract of Tamarindus indica Linn. Indian J Pharm Sci. 2011; 73(1):104-107.
Sangeetha Arullappan, Shamsul Muhamad, Zubaidah Zakaria. Cytotoxic Activity of the Leaf and Stem Extracts of Hibiscus Rosa sinensis (Malvaceae) against Leukaemic Cell Line (K-562). Trop J Pharm Res. 2013;12(5):743-746.
Alioune Dior Fall, Victor Patrick Bagla, Emmanuel Bassene, Jacobus Nicolaas Eloff. Phytochemical screening, antimicrobial and cytotoxicity studies of ethanol leaf extract of Aphania senegalensis (sapindaceae). Afr J Tradit Complement Altern Med. 2017; 14(4):135-139.
Khushbu N, Thakkar A, Prasad K, JyotiranjanNayak. Antioxidant and in vitro cytotoxic activity of extracts of aerial parts of Cocculus hirsutus (L) using cell line cultures (breast cell line). The J Phyto Pharmacol. 2014;3(6):395-399.
Tanzania Ramadhani S, Nondo O, Mainen J. Evaluation of the cytotoxic activity of extracts from medicinal plants used for the treatment of malaria in Kagera and Lindi regions. J Appl Pharm Sci. 2015;5(04):07-12.
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