Wound Healing Efficacy of Guava Leaf Extract

Main Article Content

Sarah B. Delorino
Madeline L. Ogalesco
Kaye R. Rebadulla
Myrelle Tricia A. Rongcales
Joshua Ismael A. Salubre V
Maria Kristia S. Talacay
Zalde B. Tuballas


A wound is a break in the continuity of the skin. The body’s response to injury and the restoration of the same is healing. Wound healing is a biological process that is initiated by trauma and often terminated by scar formation. In this research, guava leaf extract was used as antiseptic and its efficacy was tested to commercially available products. The result revealed that all mice which received guava leaf extract formed scar earlier as compared to povidone iodine and PNSS. Since maturation phase which also refers to remodeling phase is responsible for the new epithelium and final scar tissue formation, and as the development of these completes the complex process of wound healing, the researchers suggest that the use of guava leaf extract in comparison with povidone iodine and PNSS when it comes to wound healing is the most affordable in treatment and promoting normal and more rapid wound healing.

Wound healing, guava, leaf extract

Article Details

How to Cite
Delorino, S. B., Ogalesco, M. L., Rebadulla, K. R., Rongcales, M. T. A., Salubre V, J. I. A., Talacay, M. K. S., & Tuballas, Z. B. (2021). Wound Healing Efficacy of Guava Leaf Extract. Journal of Pharmaceutical Research International, 32(41), 27-35. https://doi.org/10.9734/jpri/2020/v32i4131041
Original Research Article


Flores AAU, Gordo CT. Study on wound healing effect of milk bush (Euphorbia tirucalli Linn) in albino mice. College of Science, University of Eastern Philippines, Catarman, Northern Samar, Philippines; 2018.

Kumar V, Khan AA. Nagarajan K. Animal models for the evaluation of wound healing activity. International Bulletin of Drug Research. 2013;3(5):93-107.

Burks RI. Povidone-iodine solution in wound treatment. Physical Therapy. 1998; 78(2):212-218.

Rahman N, Rahman H, Haris M, Mahmood R. Wound healing potentials of Thevetia peruviana: Antioxidants and inflammatory markerscriteria. Journal of Traditional and Complementary Medicine; 2017. Available:http://dx.doi.org/10.1016/j.jtcme.2017.01.005

Judit Daróczy. Quality control in chronic wound management: The role of local povidone-iodine (Betadine ®) therapy. Dermatology 2006;212(suppl1):82–87. DOI: 10.1159/000089204

Bigliardi PL, Langer S, Cruz JJ, Kim SW, Nair H, Srisawasdi G. An Asian Perspective on Povidone Iodine in Wound Healing. Dermatology. 2017;233(2-3):223-233. DOI: 10.1159/000479150.

Bigliardi PL, Latiff Alsagoff SA, El-Kafrawi HY, Pyon J-K, Cheuk Wa CT, Villa MA. Povidone iodine in wound healing: A review of current concepts and practices. International Journal of Surgery; 2017. DOI: 10.1016/j.ijsu.2017.06.073.

Lee BK, Trainor FS, Thoden WR. Topical application of povidone-iodine in management of decubitus and stasis ulcers. Journal of The American Geriatrics Society. 1979;27(7):302-306.

James Flynn. Povidone-iodine as a topical antiseptic for treating and preventing wound infection: A literature review. British Journal of Community Nursing. 2003;8(2).

Chen MT, Chang MC, Wang ST, Yu WK, Liu CL, Chen TH. Efficacy of Dilute Betadine Solution Irrigation in the Prevention of Postoperative Infection of Spinal Surgery. Spine. 2005;30(15):1689-1693.

Woo KY. Management of non-healable or maintenance wounds with topical povidone iodine. International Wound Journal. 2014; 11:622–626.

Chupeco J. Macroscopic and microscopic changes in the wound after intradermal closure buried knot and pulley knot-free patterns following ovariectomy in cats. Undergraduate Thesis. College of Veterinary Medicine UP Los Baños; 2013.

Adao J. Effect of guava (Psidium guajava) cream on the gross and microscopic features and healing rate in incisional wounds in short-haired cats. Undergraduate Thesis. College of Veterinary Medicine, UP Los Baños; 2016.