The Potential Therapeutic Advantage of Abrus precatorius Linn. an Alternative to Glycyrrhiza glabra: A Review
Journal of Pharmaceutical Research International,
Page 79-94
DOI:
10.9734/jpri/2020/v32i4031035
Abstract
Far back since the existence of the human race, plant species have been used as herb or medicine to either treat, suppress or cure the human numerous sicknesses. This poses the truth that green medicine is safe, cost-efficient, and effective with little or no side effects. Up-till date, the medicinal plant has gained world attraction which has led to global development and discovery of new drug formulations. The beneficial features of plant medicine are enormous and should not be under-estimated. However, in this study, Abrus precatorius Linn., an alternative to Glycyrrhiza glabra has been extensively reviewed to expose this herb secret to the scientific research world for the development of possible novel drug formulations in response to the present global diseases around the globe.
Keywords:
- Abrus precatorius Linn
- drug development
- drug discovery
- novel drug
How to Cite
Oladimeji, A. V., & Valan, M. F. (2021). The Potential Therapeutic Advantage of Abrus precatorius Linn. an Alternative to Glycyrrhiza glabra: A Review. Journal of Pharmaceutical Research International, 32(40), 79-94. https://doi.org/10.9734/jpri/2020/v32i4031035
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Pal, G. Ariharasivakumar, Kundlik Girhepunje, Ashutosh Upadhyay. In-Vitro Antioxidative activity of Phenolic and Flavonoid compounds extracted from Seeds of A. precatorius. Int J Pharm & Pharm Sci. 2009; 1 (2).
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Monago CC, Alumanah EO. Anti-diabetic Effect of chloroform -methanol extract of Abrus precatorius Linn Seed in Alloxan Diabetic Rabbit. J Appl Sci Environ Mgt. 2005;9(1):85–88.
Monago CC, Nwodo O Fred. Anti-diabetic Effect of crude trigonelline of Abrus precatorius Linn Seed in Alloxan Diabetic Rabbit. J Pharm Res. 2010; 3(8):1916-1919.
Dhawan BN, Patnaik GK, Rastogi RP, Singh KK, Tandon JS. Screening of Indian plants for biological activity VI. Indian J Exp Biol. 1977;15:208–219.
Georgewill OA. Evaluation of the anti-inflammatory activity of extract of Abrus precatorius. Eas J Med. 2009;14:23-25.
Anam EM. Anti-inflammatory activity of compounds isolated from the aerial parts of Abrus precatorius (Fabaceae). Phytomed. 2001;8(1):24-27.
Ligha AE, Bnr1 J, Numere NF. Protective Effect of Abrus precatorius seed extract following alcohol induced renal damage. Eur J Sci Res. 2009;25(3):428-436.
Sohn SH, Lee EY, Lee JH, Kim Y, Shin M, Hong M Bae H. Screening of herbal medicines for the recovery of acetaminophen induced nephrotoxicity. Envir Toxic Pharmacol. 2009;27:225-230.
Georgewill OA. Anti-arthritic activity of Abrus precatorius in albino rats. The Internet Journal of Laboratory Medicine 2010;4:1.
Sudaroli M, Chatterjee TK. Evaluation of red and white seed extracts of Abrus precatorius Linn. against freund's complete adjuvant induced arthritis in rats. Journal of Medicinal Plants Research. 2007;1(4):086-094.
Chistokhodova N, Nguyen C, Calvino T, Kachirskaia I, Cunningham G, Miles DH. Antithrombin activity of medicinal plants from central Florida. Journal of Ethnopharmacology. 2002;8:277-280.
Carbajal D, Casaco A, Arruzazabala L, Gonzalez R, Fuentes V. Pharmacological screening of plant decoctions commonly used in Cuban folk medicine. J Ethnopharmacol. 1991;33(1/2):21–24.
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Fennell CW, Lindsey KL, Mcgaw LJ, Sparg SG, Stafford GI, Elgorashi EE, Grace OM, Van Staden J. Review assessing African medicinal plants for efficacy and safety: Pharmacological screening and toxicology. Journal of Ethnopharmacology. 2004; 94:205–217.
Singh S, Singh DK. Effect of molluscicidal components of Abrus precatorius, Argemone mexicana and Nerium indicum on certain biochemical parameters of Lymnaea acuminate. Phytother Res. 1999;13(3):210–213.
Ratnasooriya WD, Amarasekera AS, Perera NSD, Premakumara GAS. Sperm antimotility properties of a seed extract of Abrus precatorius. J Ethnopharmacol. 1991;33(1/2):85–90.
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Limmatvapirat C, Sirisopanaporn S, Kittakoop P. Antitubercular and antiplasmodial constituents of Abrus precatorius. Planta med. 2004;70:276-278.
Chukuo S, Chen SC, Chen LH, Wu JB, Wang JP, Teng CM. Potent anti-platelet, anti-inflammatory, and anti-allergic isoflavanquinones from the roots of Abrus precatorius. Plant Medica. 1995;61(4):307-312.
Nwodo OFC, Alumanah EO. Studies on Abrus precatorius seeds II Antidiarrhoeal activity. J Ethnopharmacol. 1991;31(3): 395–398.
Chinnappan Alagesaboopathi, Rathinam Sivakumar. Studies on wound healing activity of red and block coloured seed, white coloured seed extracts of Abrus precatorius L. International Journal of Pharma and Bio Sciences. 2011;2(1).
Menan H, Banzouzi JT, Hocquette A, Pelissier Y, Blache Y, Kone M, Mallie M, Assi LA, Valentin A. Antiplasmodial activity and cytotoxicity of plants used in West African traditional medicine for the treatment of malaria. Journal of Ethnopharmacology. 2006;105:131-136.
Nwodo OFC, JH Botting. Uterotonic activity of extracts of the seeds of Abrus precatorius. Planta Med. 1983;47(4):230–233.
Chukuo S, Chen SC, Chen LH, Wu JB, Wang JP, Teng CM. Potent anti-platelet, anti-inflammatory, and anti-allergic isoflavanquinones from the roots of Abrus precatorius. Plant Medica 1995; 61 (4):307-312.
Itokawa H, Hirayama F, Tsuruoka S, Mizuno K, Takeya K, Nitta A. Screening test for antitumor activity of crude drugs (III). Studies on antitumor activity of Indonesian medicinal plants. Shoyakugaku Zasshi. 1990;44(1):58–62.
Khan AH, Gul B, Rahman MA. The interactions of the erythrocytes of various species with agglutinins of Abrus precatorius. J Immunol. 1966;96(3):554-557.
Maiti TK, Bhutia SK, Mallick SK. In vitro immunostimulatory properties of Abrus lectins derived peptides in tumor bearing mice. Phytomedicine. 2009;16:776-78.
Rao MV. Anti-fertility effects of alcoholic seeds extract of Abrus precatorius Linn. in male albino rats. Acta Eur Fertil. 1987; 18(3):217–220.
Zia-Ul-Haque, A MH Qazi, Hamdard ME. Studies on the antifertility properties of active components isolated from the seeds of Abrus precatorius Linn. Pakistan J Zool. 1983;15(2):129–139.
Samad F, Mukhtar A, Jan ZA, Khan ZU. Effect of alcohol extract of Ratti seeds (Abrus precatorius) on the reproduction of female rats. J Math Sci. 1974;12:157.
Bhaduri B, Ghose CR, Bose AN, Moza BK, Basu UP. Anti-fertility activity of some medicinal plants. Indian J Exp Biol. 1968;6:252-253.
Sinha R. Post-testicular anti-fertility effects of Abrus precatorius seed extract in albino rats. J Ethnopharmacol. 1990;28(2):173–181.
Das PC. Patent-Brit, Oral contraceptive (Longacting). 1976;11.
Agarwal SS, Ghatak N, Arora RB. Antifertility activity of the roots of Abrus precatorius. Pharmacol Res Commun. 1970;2:159–164.
Jahan S, Rasool S, Khan MA, Ahemad M, Zafar M, Arsahd M, Abbasi AM. Antifertility effects of ethanolic seed extract of Abrus precatorius L. on sperm production and DNA integrity in adult male mice. Journal of Medicinal Plant Research. 2009; 3(10):809-814.
Das PC, Sarkar AK, Thakur S. Studies on animals of a Herbo-Mineral compound for long-acting contraction. Fitoterapia. 1987; 58(4):257-261.
Sethi N, Nath D, Singh RK. Teratological aspects of Abrus precatorius seeds in rats. Fitoterapia. 1990;61(1):61–63.
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Prakash AO, Mathur R. Screening of Indian plants for antifertility activity. Indian J Exp Biol. 1976;14:623–626.
Nath D, Sethi N, Singh RK, Jain AK. Commonly used Indian abortifacient plants with special reference to their teratologic effects in rats. J Ethnopharmacol. 1992; 36(2):147–154.
Munsho SR, Shetye TA, Nair RK. Antifertility activity of three indigenous plant preparations. Planta Med. 1977; 31(1):73-5.
Prakesh AO, Gupta RB, Mathur R. Probe. Effect of oral doses of Abrus precatorius Linn. seeds on the oestrus cycle, body weight, uterine weight and cellular structures of uterus in albino rats. 1980;19:286–292.
Maiti TK, Bhutia SK, Mallick SK. In vitro immunostimulatory properties of Abrus lectins derived peptides in tumor bearing mice. Phytomedicine. 2009;16:776-78.
Jadon A, Mathur R, Jiwaji Univ J. Effects of Abrus precatorius Linn. seed extract on biochemical constituents of male mice. 1984;9(1):100–103.
Subha Reddy VV, Sirsi M. Effect of Abrus precatorius L. on experimental tumors. Cancer Res. 1969;29:1447-1451.
Panneerselvam K, lin SC, Liu CL, Liaw YC, Lin JY, Lu TH. Crystallization of agglutinin from the seeds of Abrus precatorius. Acta Crystallographica Section D Biological Crystallography. 2000;56(7):898–899.
Ramaswami K, Chandana VR, Palpu P, Sunil PT, Gaddam DR. Exploring the Protective Effects of Abrus precatorius in HepG2 and N-Nitrosodiethylamine-induced hepatocellular carcinoma in swiss albino rats. Iran J Pharm Sci Spring. 2010;6(2):99-114.
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Krupe M, Wirth W, Nies D, Ensgraber AZ. Immunitatsforsch allerg klin immunol, studies on the "Mitogenic" effect of hemoglutinating extracts of various plants on the human small lymphocytes in peripheral blood cultured in vitro. 1968; 135(1): 19–42.
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Hussein Ayoub SM, DGI Kingston. Screening of plants in Sudan folk medicine for anticancer activity. Fitoterapia. 1982; 53:119–123.
Tomita M, Kurokawa T, Onozaki K, Osawa T, Sakurai Y, Ukita T. The surface structure of murine ascites tumors 11. Difference in cytotoxicity of various phytoagglutinins toward Yoshida Sarcoma cells in vitro. Int J Cancer. 1972;10:602.
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Ramnath V, Kuttan G, Kuttan R. Immunotoxicol, Effect of abrin on cell mediated immune responses in mice. Immunopharmacol. 2006;28(2):259-268.
Tripathi S, Maiti TK. Immunomodulatory role of native and heat denatured agglutinin from Abrus precatorius. The Inter J Biochem Cell boil. 2005;37:451-462.
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Kalpesh Mistry, Mansi Mehta, Nehal Mendpara, Sharmila Gamit, Gaurav Shah. Determination of antibacterial activity and MIC of Crude Extract of Abrus precatorius L. Advanced Biotech. 2010;10:2.
Sirsi M. In Vitro study of the Inhibitory action of some chemotherapeutic agents on a freshly isolated strain of Cryptococcus neoformans. Hindust. Antibiot. Bull. 1963;6(2):39-40.
Pal, G. Ariharasivakumar, Kundlik Girhepunje, Ashutosh Upadhyay. In-Vitro Antioxidative activity of Phenolic and Flavonoid compounds extracted from Seeds of A. precatorius. Int J Pharm & Pharm Sci. 2009; 1 (2).
Otake T, H Mori, Morimoto M, Ueba N, Sutardio S, Kusumoto I, Hattori M, Namba T. Screening of Indonesian plant extracts for antihuman immunodeficiency virus-Type 1 (HIV-1) activity. Phytother Res. 1995;9(1):6–10.
Monago CC, Alumanah EO. Anti-diabetic Effect of chloroform -methanol extract of Abrus precatorius Linn Seed in Alloxan Diabetic Rabbit. J Appl Sci Environ Mgt. 2005;9(1):85–88.
Monago CC, Nwodo O Fred. Anti-diabetic Effect of crude trigonelline of Abrus precatorius Linn Seed in Alloxan Diabetic Rabbit. J Pharm Res. 2010; 3(8):1916-1919.
Dhawan BN, Patnaik GK, Rastogi RP, Singh KK, Tandon JS. Screening of Indian plants for biological activity VI. Indian J Exp Biol. 1977;15:208–219.
Georgewill OA. Evaluation of the anti-inflammatory activity of extract of Abrus precatorius. Eas J Med. 2009;14:23-25.
Anam EM. Anti-inflammatory activity of compounds isolated from the aerial parts of Abrus precatorius (Fabaceae). Phytomed. 2001;8(1):24-27.
Ligha AE, Bnr1 J, Numere NF. Protective Effect of Abrus precatorius seed extract following alcohol induced renal damage. Eur J Sci Res. 2009;25(3):428-436.
Sohn SH, Lee EY, Lee JH, Kim Y, Shin M, Hong M Bae H. Screening of herbal medicines for the recovery of acetaminophen induced nephrotoxicity. Envir Toxic Pharmacol. 2009;27:225-230.
Georgewill OA. Anti-arthritic activity of Abrus precatorius in albino rats. The Internet Journal of Laboratory Medicine 2010;4:1.
Sudaroli M, Chatterjee TK. Evaluation of red and white seed extracts of Abrus precatorius Linn. against freund's complete adjuvant induced arthritis in rats. Journal of Medicinal Plants Research. 2007;1(4):086-094.
Chistokhodova N, Nguyen C, Calvino T, Kachirskaia I, Cunningham G, Miles DH. Antithrombin activity of medicinal plants from central Florida. Journal of Ethnopharmacology. 2002;8:277-280.
Carbajal D, Casaco A, Arruzazabala L, Gonzalez R, Fuentes V. Pharmacological screening of plant decoctions commonly used in Cuban folk medicine. J Ethnopharmacol. 1991;33(1/2):21–24.
Hartzell A, Wilcoxon F. Contr Boyce Thompson Inst, A survey of plant products for insecticidal properties. 1941;12:127–141.
Mameesh MS, El-Hakim LM, Hassan A. Reproductive failure in female rats fed the fruit or seed of Jatropha curcas. Planta Med. 1941;11:98.
Fennell CW, Lindsey KL, Mcgaw LJ, Sparg SG, Stafford GI, Elgorashi EE, Grace OM, Van Staden J. Review assessing African medicinal plants for efficacy and safety: Pharmacological screening and toxicology. Journal of Ethnopharmacology. 2004; 94:205–217.
Singh S, Singh DK. Effect of molluscicidal components of Abrus precatorius, Argemone mexicana and Nerium indicum on certain biochemical parameters of Lymnaea acuminate. Phytother Res. 1999;13(3):210–213.
Ratnasooriya WD, Amarasekera AS, Perera NSD, Premakumara GAS. Sperm antimotility properties of a seed extract of Abrus precatorius. J Ethnopharmacol. 1991;33(1/2):85–90.
Satyanarayana K, Sukumar K. Phytosterilants to control the cotton bug, Dysdercus cingulatus F. Curr Sci. 1988;57(16):918–919.
Limmatvapirat C, Sirisopanaporn S, Kittakoop P. Antitubercular and antiplasmodial constituents of Abrus precatorius. Planta med. 2004;70:276-278.
Chukuo S, Chen SC, Chen LH, Wu JB, Wang JP, Teng CM. Potent anti-platelet, anti-inflammatory, and anti-allergic isoflavanquinones from the roots of Abrus precatorius. Plant Medica. 1995;61(4):307-312.
Nwodo OFC, Alumanah EO. Studies on Abrus precatorius seeds II Antidiarrhoeal activity. J Ethnopharmacol. 1991;31(3): 395–398.
Chinnappan Alagesaboopathi, Rathinam Sivakumar. Studies on wound healing activity of red and block coloured seed, white coloured seed extracts of Abrus precatorius L. International Journal of Pharma and Bio Sciences. 2011;2(1).
Menan H, Banzouzi JT, Hocquette A, Pelissier Y, Blache Y, Kone M, Mallie M, Assi LA, Valentin A. Antiplasmodial activity and cytotoxicity of plants used in West African traditional medicine for the treatment of malaria. Journal of Ethnopharmacology. 2006;105:131-136.
Nwodo OFC, JH Botting. Uterotonic activity of extracts of the seeds of Abrus precatorius. Planta Med. 1983;47(4):230–233.
Chukuo S, Chen SC, Chen LH, Wu JB, Wang JP, Teng CM. Potent anti-platelet, anti-inflammatory, and anti-allergic isoflavanquinones from the roots of Abrus precatorius. Plant Medica 1995; 61 (4):307-312.
Itokawa H, Hirayama F, Tsuruoka S, Mizuno K, Takeya K, Nitta A. Screening test for antitumor activity of crude drugs (III). Studies on antitumor activity of Indonesian medicinal plants. Shoyakugaku Zasshi. 1990;44(1):58–62.
Khan AH, Gul B, Rahman MA. The interactions of the erythrocytes of various species with agglutinins of Abrus precatorius. J Immunol. 1966;96(3):554-557.
Maiti TK, Bhutia SK, Mallick SK. In vitro immunostimulatory properties of Abrus lectins derived peptides in tumor bearing mice. Phytomedicine. 2009;16:776-78.
Rao MV. Anti-fertility effects of alcoholic seeds extract of Abrus precatorius Linn. in male albino rats. Acta Eur Fertil. 1987; 18(3):217–220.
Zia-Ul-Haque, A MH Qazi, Hamdard ME. Studies on the antifertility properties of active components isolated from the seeds of Abrus precatorius Linn. Pakistan J Zool. 1983;15(2):129–139.
Samad F, Mukhtar A, Jan ZA, Khan ZU. Effect of alcohol extract of Ratti seeds (Abrus precatorius) on the reproduction of female rats. J Math Sci. 1974;12:157.
Bhaduri B, Ghose CR, Bose AN, Moza BK, Basu UP. Anti-fertility activity of some medicinal plants. Indian J Exp Biol. 1968;6:252-253.
Sinha R. Post-testicular anti-fertility effects of Abrus precatorius seed extract in albino rats. J Ethnopharmacol. 1990;28(2):173–181.
Das PC. Patent-Brit, Oral contraceptive (Longacting). 1976;11.
Agarwal SS, Ghatak N, Arora RB. Antifertility activity of the roots of Abrus precatorius. Pharmacol Res Commun. 1970;2:159–164.
Jahan S, Rasool S, Khan MA, Ahemad M, Zafar M, Arsahd M, Abbasi AM. Antifertility effects of ethanolic seed extract of Abrus precatorius L. on sperm production and DNA integrity in adult male mice. Journal of Medicinal Plant Research. 2009; 3(10):809-814.
Das PC, Sarkar AK, Thakur S. Studies on animals of a Herbo-Mineral compound for long-acting contraction. Fitoterapia. 1987; 58(4):257-261.
Sethi N, Nath D, Singh RK. Teratological aspects of Abrus precatorius seeds in rats. Fitoterapia. 1990;61(1):61–63.
Popli SP. Screening of Indian indigenous plants for antifertility activity. Progress report on project 74219 (WHO); 1977.
Prakash AO, Mathur R. Screening of Indian plants for antifertility activity. Indian J Exp Biol. 1976;14:623–626.
Nath D, Sethi N, Singh RK, Jain AK. Commonly used Indian abortifacient plants with special reference to their teratologic effects in rats. J Ethnopharmacol. 1992; 36(2):147–154.
Munsho SR, Shetye TA, Nair RK. Antifertility activity of three indigenous plant preparations. Planta Med. 1977; 31(1):73-5.
Prakesh AO, Gupta RB, Mathur R. Probe. Effect of oral doses of Abrus precatorius Linn. seeds on the oestrus cycle, body weight, uterine weight and cellular structures of uterus in albino rats. 1980;19:286–292.
Maiti TK, Bhutia SK, Mallick SK. In vitro immunostimulatory properties of Abrus lectins derived peptides in tumor bearing mice. Phytomedicine. 2009;16:776-78.
Jadon A, Mathur R, Jiwaji Univ J. Effects of Abrus precatorius Linn. seed extract on biochemical constituents of male mice. 1984;9(1):100–103.
Subha Reddy VV, Sirsi M. Effect of Abrus precatorius L. on experimental tumors. Cancer Res. 1969;29:1447-1451.
Panneerselvam K, lin SC, Liu CL, Liaw YC, Lin JY, Lu TH. Crystallization of agglutinin from the seeds of Abrus precatorius. Acta Crystallographica Section D Biological Crystallography. 2000;56(7):898–899.
Ramaswami K, Chandana VR, Palpu P, Sunil PT, Gaddam DR. Exploring the Protective Effects of Abrus precatorius in HepG2 and N-Nitrosodiethylamine-induced hepatocellular carcinoma in swiss albino rats. Iran J Pharm Sci Spring. 2010;6(2):99-114.
Lalithakumari H, Reddy VVS, Rao GR, Sirsi M. Purification of proteins from Abrus precatorius and their biological properties. Indian J Biochem Biophys. 1971;8:321.
Krupe M, Wirth W, Nies D, Ensgraber AZ. Immunitatsforsch allerg klin immunol, studies on the "Mitogenic" effect of hemoglutinating extracts of various plants on the human small lymphocytes in peripheral blood cultured in vitro. 1968; 135(1): 19–42.
Choi YH, Hussain RA, Pezzuto JM, Kinghorn AD, Morton JF. Abrososides A-D. Four novel sweet-tasting triterpene glycosides from the leaves of Abrus precatorius. J Nat Prod. 1989;52(5):1118–1127.
Hussein Ayoub SM, DGI Kingston. Screening of plants in Sudan folk medicine for anticancer activity. Fitoterapia. 1982; 53:119–123.
Tomita M, Kurokawa T, Onozaki K, Osawa T, Sakurai Y, Ukita T. The surface structure of murine ascites tumors 11. Difference in cytotoxicity of various phytoagglutinins toward Yoshida Sarcoma cells in vitro. Int J Cancer. 1972;10:602.
ANON. Unpublished data, National Cancer Institute. National Cancer Inst. Central Files; 1976.
Desai VB, Sirsi M, Shankarappa M, Kasturibai AR. Studies on the toxicity of Abrus precatorius effect of aqueous extracts of seeds on mitosis and meiosis in grasshopper, (Poecilocera picta). Indian J Exp Biol. 1966;4:164.
Bhutia SK, Mallick SK, Maiti S, Maiti TK. Inhibitory effect of Abrus abrin derived peptide fraction against Dalton's lymphoma ascites model. 2009;16:377-385.
Kusumot IT, Shimada I, Kakiuchi N, Hattori M, Namba T, Supriyatna S. Inhibitory effect of Indonesian plant extracts on reverse transcriptase of an RNA tumour virus. Phytother Res. 1992;6(5):241–244.
Ramnath V, Kuttan G, Kuttan R. Immunotoxicol, Effect of abrin on cell mediated immune responses in mice. Immunopharmacol. 2006;28(2):259-268.
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