Controlled Release of Bi-Layered Malvidin Tablets Using 3D Printing Techniques
Journal of Pharmaceutical Research International,
Page 70-78
DOI:
10.9734/jpri/2020/v32i4031034
Abstract
Malvidin belongs to the class of anthocyanidin, a pigment compound present in fruits and vegetables like the colored berries, flowers, and vegetables which have pigments on it and it is available commercially as malvidin chloride. Malvidin is known to possess many medicinal characteristics like anti-microbial, anti-diabetic, anti-inflammatory, anti-obesity, and anti-cancer. In this research paper, a 3D printing technique is used which evolves a 3D printer based on desktop that extrudes tablets comprising the active drug which here is malvidin our main ingredient and the other excipients which are used as binders and disintegrants. Methods which are adapted here for the formulation of 3D printed tablet make the tablets appropriate for immediate and sustained release with its definite physical and mechanical properties like hardness, friability, and weight. Tablets that are extruded by the 3D printer are controlled release bi-layer tablets. Due to involvement of 3D printer, printing cost for the bi-layered tablets found very low that makes our method as cost efficient.
Keywords:
- Anthocyanidin
- bi-layer tablets
- malvidin
- 3D printer
How to Cite
References
Malvidin chloride C17H15ClO7. PubChem; 2017. Available:https://pubchem.ncbi.nlm.nih.gov/compound/Malvidin-chloride Accessed Aug. 21, 2020.
Howard AN. Solubilization of flavonols. US 6,569,446 B1; 2003.
Wang H, Cao G, Prior RL. Oxygen radical absorbing capacity of anthocyanins. J. Agric. Food Chem; 1997. DOI: 10.1021/jf960421t
Azevedo J, et al. Antioxidant properties of anthocyanidins, anthocyanidin-3-glucosides and respective portisins. Food Chem. 2010;119(2):518–523. DOI: https://doi.org/10.1016/j.foodchem. 2009.06.050
Laleh GH, Frydoonfar H, Heidary R, Jameei R, Zare S. The effect of light, temperature, pH and species on stability of anthocyanin pigments in four Berberis species. Pakistan J. Nutr; 2006. DOI: 10.3923/pjn.2006.90.92
Panche AN, Diwan AD, Chandra SR. Flavonoids: An overview. J. Nutr. Sci. 2016;5:e47–e47. DOI: 10.1017/jns.2016.41
Khoo HE, Azlan A, Tang ST, Lim SM. Anthocyanidins and anthocyanins: Colored pigments as food, pharmaceutical ingredients, and the potential health benefits. Food & Nutr. Res. SE-Review Articles. 2017;61(0). Available:https://foodandnutritionresearch.net/index.php/fnr/article/view/1257
He K, et al. Evaluation of antidiabetic potential of selected traditional Chinese medicines in STZ-induced diabetic mice. J. Ethnopharmacol; 2011. DOI: 10.1016/j.jep.2011.07.033
Herbadiet Natural antioxidants Blueberry Extract 10:1 Powder Supplement – herbadiet; 2020. Available:https://herbadiet.in/products/herbadiet-natural-antioxidants-blueberry-extract-10-1-powder-memory-supplement?variant=1691953168410
Alhnan MA, Okwuosa TC, Sadia M, Wan KW, Ahmed W, Arafat B. Emergence of 3D printed dosage forms: Opportunities and Challenges. Pharmaceutical Research; 2016. DOI: 10.1007/s11095-016-1933-1
Rowe CW, Katstra WE, Palazzolo RD, Giritlioglu B, Teung P, Cima MJ. Multimechanism oral dosage forms fabricated by three dimensional printing(TM). J. Control. Release; 2000. DOI: 10.1016/S0168-3659(99)00224-2
Sastry SV, Nyshadham JR, Fix JA. Recent technological advances in oral drug delivery - A review. Pharmaceutical Science and Technology Today; 2000. DOI: 10.1016/S1461-5347(00)00247-9
Jivraj M, Martini LG, Thomson CM. An overview of the different excipients useful for the direct compression of tablets. Pharmaceutical Science and Technology Today; 2000. DOI: 10.1016/S1461-5347(99)00237-0
Rosca ID, Vergnaud JM. Evaluation of the characteristics of oral dosage forms with release controlled by erosion. Comput. Biol. Med; 2008. DOI: 10.1016/j.compbiomed.2008.03.001
Parmar J, Rane M. Tablet formulation design and manufacture: Oral immediate release application. Pharma Times; 2009.
GM pharmaceutical preformulation and formulation: A practical guide from candidate drug selection to commercial dosage form. New York; 2009.
Scoutaris N, Alexander MR, Gellert PR, Roberts CJ. Inkjet printing as a novel medicine formulation technique. J. Control. Release; 2011. DOI: 10.1016/j.jconrel.2011.07.033
Sandler N, et al. Inkjet printing of drug substances and use of porous substrates-towards individualized dosing. J. Pharm. Sci; 2011. DOI: 10.1002/jps.22526
Katstra WE, Palazzolo RD, Rowe CW, Giritlioglu B, Teung P, Cima MJ. Oral dosage forms fabricated by Three Dimensional Printing(TM). J. Control. Release; 2000. DOI: 10.1016/S0168-3659(99)00225-4
Abd-Allah FI, Dawaba HM, Ahmed AM. Preparation, characterization, and stability studies of piroxicam-loaded microemulsions in topical formulations. Drug Discov. Ther; 2010.
Blume RW, Davis RD, Keyser DJ. Guaifenesin sustained release formulation and tablets. US. 6,372,252 B1; 2002.
Remington JP, Beringer P. Remington : The science and practice of pharmacy. Philadelphia: Lippincott Williams & Wilkins; 2006.
Bushra R, Shoaib MH, Aslam N, Hashmat D, Masud-Ur-Rehman. Formulation development and optimization of ibuprofen tablets by direct compression method. Pak. J. Pharm. Sci; 2008.
Folttmann H, Quadir A. Copovidone - A copolymer with unique formulation properties. Drug Deliv. Technol; 2008.
United States Pharmacopeial Convention, The United States Pharmacopeia : USP 24 : the National Formulary : NF 19, March 9-12, 1995 ; Rockville, Md. Rockville, Md.: United States Pharmacopeial Convention; 1999.
Nagadivya P, Ramakrishna R, Sridhar G, Bhanushashank R. Effect of various binding agents on tablet hardness and release rate profiles of diclofenac sodium tablets. Int. J. Res. Pharm. Sci; 2012.
Patra CN, Kumar AB, Pandit HK, Singh SP, Devi MV. Design and evaluation of sustained release bilayer tablets of propranolol hydrochloride. Acta Pharm; 2007. DOI: 10.2478/v10007-007-0038-0
Bijank G, Rabindra D, Soumyadeep G, Manas C, Amitava B. Formulation development studies of bilayer tablet glipizide: A novel and evolutionary approach in the treatment of diabetes. Asian J. Pharm. Clin. Res; 2013.
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