A Study on Haematological Profile in Clinically Suspected Cases of Neonatal Sepsis

Main Article Content

S. R. Upadhey
Avinash M. Mane
Atul B. Hulwan
Rohit S. Kadam
Dhirajkumar Mane


The present study was a two year observational study of haematological profile in clinically suspected cases of neonatal sepsis. Study analyzed the haematological findings according to Rodwell’s haematological scoring system in neonates clinically suspicious of having sepsis. It included 108 neonates admitted in NICU of our hospital during the study period of June 2015 to May 2017. According to clinical findings, Rodwell’s hematological score and blood culture positivity 108 neonates were divided into three groups; proven sepsis, probable sepsis and no sepsis. Study show that Rodwell’s haematological scoring system is a simple, quick, cost effective tool which can be used as screening test for early diagnosis of neonatal sepsis.

Neonatal sepsis, haematological scoring, erythrocyte sedimentation, rodwells’ hematological score.

Article Details

How to Cite
Upadhey, S. R., Mane, A. M., Hulwan, A. B., Kadam, R. S., & Mane, D. (2020). A Study on Haematological Profile in Clinically Suspected Cases of Neonatal Sepsis. Journal of Pharmaceutical Research International, 32(29), 97-101. https://doi.org/10.9734/jpri/2020/v32i2930889
Original Research Article


Sharma M, Yadav A, Yadav S, Goel N, Chaudhary U. Microbial profile of septicemia in children. Indian Journal for the Practising Doctor. 2008;5:9-10.

Darmstadt GL, Saha SK, Choi Y, Arifeen SE. Population- based incidence and etiology of community- acquired neonatal bacteremia in Mirzapur, Bangladesh: An observational study. J Infect Dis.2009; 200:906-15.

Osman AS, Awadallah MG, Tabl HA, Abed NT, Goudah ES. Presepsin as a novel diagnostic marker in neonatal septicemia. The Egyptian Journal of Medical Micro-biology (EJMM). 2015;24(3).

Venkatesh M, Flores A, Luna RA, Versalovic J. Molecular microbiological methods in the diagnosis of neonatal sepsis. Expert review of anti-infective therapy. 2010;8(9):1037-48.

Arif SH, Ahmad I, Ali SM, Khan HM. Thrombocytopenia and bacterial sepsis in neonates. Indian Journal of Hematology and Blood Transfusion. 2012;28(3):147-51.

Dunkel B, Corley KT. Pathophysiology, diagnosis and treatment of neonatal sepsis. Equine Veterinary Education. 2015;27(2): 92-8.

Samanta S, Farrer K, Breathnach A, Heath PT. Risk factors for late onset gram negative infections: a case-control study. Arch Dis Childhood 2011;96(1):F15-8.

Viswanathan R, Singh AK, Basu S, Chatterjee S, Sardar S, Isaacs D. Multi-drug resistant gram negative bacilli causing early neonatal sepsis in India. Archives of Disease in Childhood-Fetal and Neonatal Edition. 2012;97(3):F182-7.

Hornik CP, Fort P, Clark RH, Watt K, Benjamin Jr DK, Smith PB, Manzoni P, Jacqz-Aigrain E, Kaguelidou F, Cohen-Wolkowiez M. Early and late onset sepsis in very-low-birth-weight infants from a large group of neonatal intensive care units. Early human development. 2012;88:S69-74.

Penders J, Thijs C, Vink C, Factors influencing the composition of the intestinal microbiota in early infancy. Pediatr. 2006; 118(2):511-521.

Bhat R, Lewis LE, Vandana KE. Bacterial isolates of early-onset neonatal sepsis and their antibiotic susceptibility pattern between 1998 and 2004: An audit from a center in India. Italian journal of pediatrics. 2011; 37(1):1-6.

Hisamuddin E, Hisam A, Wahid S, Raza G. Validity of C-reactive protein (CRP) for diagnosis of neonatal sepsis. Pakistan Journal of Medical Sciences. 2015;31(3): 527.

Benitz WE. Adjunct laboratory tests in the diagnosis of early-onset neonatal sepsis. Clinics in Perinatology. 2010;37(2):421- 38.

Hofer N, Zacharias E, Müller W, Resch B. An update on the use of C-reactive protein in early-onset neonatal sepsis: Current insights and new tasks. Neonatology. 2012;102(1):25-36.