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Background: Our previous study of the lipid peroxidation and antioxidant defense system (LPO-AOS) state in women with chronic viral hepatitis (CVH) showed the content of fat-soluble vitamin alpha tocopherol significant reduction. Reproductive health of women with CVH needs special attention. The objectives of this study was to determine the frequency of menstrual disorders in the group of women with CVH with marked alpha tocopherol insufficiency.
Study Design: A case-control study.
Place and Duration of Study: A study was conducted at Scientific Centre for Family Health and Human Reproduction Problems and in the hepatological department of the Irkutsk clinical hospital of infectious diseases from 2010 to 2014. This work was performed with the use of equipment of Collective research centre “Center for the development of progressive personalized technologies for health” SC FHHRP, Irkutsk.
Methods and Results: Our study included 44 reproductive age women with CVH and comparable age 28 healthy women. All women underwent clinical examination and questionary survey. We found alpha tocopherol insufficiency in 95.5% cases of patients with CVH and menstrual disorders.
Conclusion: Our results suggest that menstrual disorders in patients with CVH may be associated with alpha tocopherol insufficiency.
Gilson R, Brook MG. Hepatitis A, B, and C. Sex Transm Infect. 2006;82(Suppl IV):35–39. DOI: 10.1136/sti.2006.023218.
Savilov ED, Chemezova NN, Astafev VA, Malov IV, Malov SI, Gavrilova TA, Burdanova TM, Vladykina AV, Chubukin EA. [Parenteral viral hepatitises in the Irkutsk region]. Acta biomedical scientifica. 2018;3(4):148-153. DOI: 10.29413/ABS.2018-3.5.22 [Article in Russian].
Aman W, Mousa S, Shiha G, Mousa SA. Current status and future directions in the management of chronic hepatitis C. Virology Journal. 2012;9(1):57. DOI: 10.1186/1743-422x-9-57.
Pirayvatlou PS, Alavian SM, Pirayvatlou SS, Pouyan SP, Mina M, Madjad E. Efficacy of DAA-based Antiviral Therapies for HCV Patients with Chronic Kidney Disease: A Meta-analysis. Journal of pharmaceutical research international. 2019;31(6):1-10. DOI: 10.9734/JPRI/2019/v31i630328
Darenskaya MA, Grebenkina LA, Sholokhov LF, Rashidova MA, Semenova NV, Kolesnikov SI, Kolesnikova LI. Lipid Peroxidation Activity in Women with Chronic Viral Hepatitis. FRBM. 2016;100:S192. DOI: 10.1016/j.freeradbiomed.2016.10.525.
Rashidova MA, Sholokhov LF, Darenskaya MA, Kolesnikova LI. Functional state of the thyroid gland and lipid peroxidation and antioxidant protection system in women of reproductive age with chronic form of parenteral viral hepatitis. Acta biomedical scientifica. 2019;4(1):31-35. DOI: 10.29413/ABS.2019-4.1.5 [Article in Russian]
Atalyan AV, Shelokhov LF, Kolesnikova LI. Endocrine Markers of Fertility Potential in Reproductive Age Women with Idiopathic Hyperprolactinemia. Journal of pharmaceutical research international. 2020;32(23):71-77. DOI: 10.9734/JPRI/2020/v32i2330790.
Jilani T, Iqbal MP. Vitamin E deficiency in South Asian population and the therapeutic use of alpha-tocopherol (Vitamin E) for correction of anemia. Pak J Med Sci. 2018;34(6):1571-1575. DOI: doi.org/10.12669/pjms.346.15880.
Kolesnikova LI, Semyonova NV, Grebenkina LA, Darenskaya MA, Suturina LV, Gnusina SV. Integral indicator of oxidative stress in human blood. Bull Exp Biol Med. 2014;157(6):715-7. DOI: 10.1007/s10517-014-2649-z.
Kamyshnikov VS. Handbook of clinical and biochemical studies and laboratory diagnostics, 3rd edition. Moscow. MEDpress-Inform. 2009;896 [Article in Russian].
Dokin VN, Mikhalvich IM. Fundamentals of probability theory and mathematical statistics in biomedical research. Manual.- Irkutsk. 2013;79. [ArticleinRussian].
Kolesnikova L, Semenova N, Madaeva I, Suturina L, Solodova E, Grebenkina L, Darenskaya M. Antioxidant status in peri- and postmenopausal women. Maturitas. 2015;81(1):83-87. DOI: 10.1016/j.maturitas.2015.02.264
Kozak MV, Teplyĭ DL. Morphofunctional status of gonadotropic cells of the adenohypophysis at early stages of age involution. AdvGerontol. 2007;20(4):25- 30. [Article in Russian].
Wang S, He G, Chen M, Zuo T, Xu W, Liu X. The Role of Antioxidant Enzymes in the Ovaries.Oxidative Medicine and Cellular Longevity. 2017;2017:1–14. DOI: 10.1155/2017/4371714