Olive Oil Based Organogels for Effective Topical Delivery of Fluconazole: In-vitro Antifungal Study
Journal of Pharmaceutical Research International,
The objective of the study was to formulate olive oil based organogels for the topical application of fluconazole (FLZ), to ensure the efficient delivery of the drug deeper in to the skin layers.
Methods: Nine formulations developed by hot-melt method using olive oil, sorbitan monostearate (SMS) and FLZ. Prepared formulations characterized for macro evaluations, pH, spreadibility, viscosity, gel-sol transition, in-vitro diffusion study. Further optimized formulation evaluated for ex-vivo percutaneous permeation, in-vitro antifungal studies and stability studies by similarity index. Results: The results of evaluated parameters ensure the stability and effectiveness of the prepared olive oil based organogels. In-vitro diffusion studied reflects decrease in drug release with increase in surfactant concentration due to increase in viscosity. Moreover, ex-vivo permeation studies revealed that the permeation of FLZ was enhanced for optimized formulations (F6) as compared to the marketed gel formulation. Further, the optimized formulation exhibits the broad zone of inhibition against fungal strains in comparison to control and marketed product during in-vitro antifungal study.
Conclusion: The olive oil based organogels formulation shown the enhanced permeation of FLZ from organogel network structure with good antifungal activity as compared to the marketed formulation. Henceforth, the FLZ organogel formulations could be used topically for the effective treatment of fungal infection.
- olive oil
- In-vitro antifungal activity
- ex-vivo permeation
How to Cite
Parker JE, Warrilow AG, Price CL, Mullins JG, Kelly DE, Kelly SL. Resistance to antifungals that target CYP51. J Chem Biol. 2014;7(4):143-161.
Esposito C, Kirilov P, Roullin V. Organogels, promising drug delivery systems: an update of state-of-the-art and recent applications. Journal of Controlled Release. 2018;271:1-20.
Mohammed A, Faisal W, Saleh K, Osman S. Self-assembling organogels based on pluronic and lecithin for sustained release of etodolac: In vitro and In vivo Correlation. Current Drug Delivery. 2017;14(7).
Morrow D, McCarron P, Woolfson A, Donnelly R. Innovative strategies for enhancing topical and transdermal drug delivery. The Open Drug Delivery Journal. 2007;1(1):36-59.
Bartocci S, Morbioli I, Maggini M, Mba M. Solvent-tunable morphology and emission of pyrene-dipeptide organogels. Journal of Peptide Science. 2015;21(12):871-878.
Liu Y, Pandey R. Sol–gel phase transitions in thermoreversible gels: Onset of gelation and melting. The Journal of Chemical Physics. 1996;105(2):825-836.
Barakat N. Optimization of physical characterization, skin permeation of naproxen from glycofurol-based topical gel. Asian Journal of Pharmaceutics. 2010; 4(2):154.
Kantaria S, Rees G, Lawrence M. Gelatin-stabilised microemulsion-based organogels: Rheology and application in iontophoretic transdermal drug delivery. Journal of Controlled Release. 1999;60(2-3):355-365.
Tirunagari M, Sameen J, Nandagopal A. Formulation development and characterization of oxcarbazepine microemulsion for intranasal delivery. ACTA Pharmaceutica Sciencia. 2017; 55(2):79.
Chakraborti CK, Sahoo S, Behera PK. Effect of different polymers on in vitro and ex vivo permeability of Ofloxacin from its mucoadhesive suspensions. Saudi Pharm J. 2015;23(2):195-201
Tas C, Ozkan Y, Okyar A, Savaser A. In vitro and Ex vivo Permeation studies of etodolac from hydrophilic gels and effect of terpenes as enhancers. Drug Delivery. 2007;14(7):453-459.
Chaudhary A, Nandan Rahul S. Antibacterial activity of Punica granatum (Pomegranate) fruit peel extract against pathogenic and drug resistance bacterial strains. International Journal of Current Microbiology and Applied Sciences. 2017; 6(12):3802-3807.
Abdallah MH, Lila ASA, Anwer MK, Khafagy ES, Mohammad M, Soliman SM. Formulation, development and evaluation of ibuprofen loaded nano-transferosomal gel for the treatment of psoriasis. Journal of Pharmaceutical Research International, 2019; 31(6): , 1-8.
Abstract View: 291 times
PDF Download: 191 times