Thyroid Dysfunction and Infertility of Women of Reproductive Age

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Ekaterina Andreevna Sterlyova
Tatiana Kharitonovna Timokhina
Yuriy Viktorovich Sivkov
Alexandr Anatolyevich Markov
. Huldani
Vitaly V. Goncharov
Harun Achmad


Autoimmunity of the thyroid gland (TAI) or its dysfunction is quite common among women of reproductive age, and there are suggestions in the literature that they are associated with an unfavorable level of fertility and a negative outcome of pregnancy, as in the case of spontaneous conception or after assisted reproductive technologies (ART).

This assumption makes it necessary to screen autoantibodies to thyrotropin (TSH) and thyroid peroxidase among infertile women who have made a number of attempts to become pregnant.

Some authors have conducted a number of studies where they have examined the relationship between autoimmunity of the thyroid gland, thyroid function, and fertility. However, there is currently no consensus on the upper limit of the norm for TSH to determine thyroid dysfunction and the limits for intervention. Despite the recent update of the American thyroid Association (ATA) on guidelines for the diagnosis and treatment of thyroid diseases during pregnancy and the postpartum period, many issues remain unresolved in ART. The author came to the following conclusions: open thyroid dysfunction often leads to menstrual disorders, fertility problems, and pregnancy complications, and therefore should be treated accordingly. Currently, there is little evidence to recommend treatment with levothyroxine at TSH levels between 2.5 and 4.0 MMU / l, given the possible side effects of overtreatment, especially in patients with mild thyroid dysfunction. We suggest careful longitudinal monitoring, especially in the presence of thyroid antibodies in women undergoing ART. The 4 MMU / l limit for TSH appears as the intervention level for SCH treatment in women with and without transabdominal utrasound in ART.

Thyroid, autoimmunity, infertility, assisted reproductive technologies.

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How to Cite
Sterlyova, E. A., Timokhina, T. K., Sivkov, Y. V., Markov, A. A., Huldani, ., Goncharov, V. V., & Achmad, H. (2020). Thyroid Dysfunction and Infertility of Women of Reproductive Age. Journal of Pharmaceutical Research International, 32(23), 124-132.
Original Research Article


Evers JLH. Female subfertility. Lancet. 2002;360:151-159.

Poppe K, Glinoer D, Van Steirteghem A, et al. Thyroid dysfunction and autoimmunity in infertile women Thyroid. 2002;12:997-1001.

Iravani AT, Saeedi MM, Pakravesh J, et al. Thyroid autoimmunity and recurrent spontaneous abortion in Iran: A case-control study Endocr Pract. 2008;14:458-464.

Alexander EK, Elizabeth N, Pearce EN, et al. Guidelines of the American thyroid association for the diagnosis and management of thyroid disease during pregnancy and the postpartum Thyroid. 2017;27:315-389.

Aghajanova L, Lindeberg M, Carlsson IB, et al. Receptors for thyroid- stimulating hormone and thyroid hormones in human ovarian tissue Reprod Biomed Online. 2009;18:337- 347.

Millar LK, Wing DA, Leung AS, et al. Low birth weight and preeclampsia, in pregnancies complicated by hyperthyroidism Obstet Gynecol. 1994;84: 946-949.

McElduff A, Morris J. Thyroid function tests and thyroid autoantibodies in an unselected population of women undergoing first trimester screening for aneuploidy Aust N Z J Obstet Gynaecol. 2008;48:478-480.

Krassas GE, Poppe K, Glinoer D. Thyroid function and human reproductive health Endocr Rev. 2010;31: 702-755.

Poppe K, Glinoer D, Tournaye H, et al. Impact of ovarian hyperstimulation on thyroid function in women with – and without thyroid autoimmunity J Clin Endocrinol Metab. 2004;89:3808-3812.

Achmad H, Hendra Chandha, Sri Harun, Sudjarwo I, Yunus M, Rahma K. Rusdi, Khairunnisa P. Prevalence of Medically Compromised Children Regarding Dental Caries and Treatment Needs in Wahidin Sudirohusodo Hospital, Journal of International Dental and Medical Research. 2017;10(3):915-920. ISSN 1309-100X.

Markov Alexander. Results of the Experimental Research and Clinical Application of Cannulated Screw with Bioactive Coverage on the Basis of Natural Hydroxiapatite during Osteosynthesis of Medial Fractures of Femur’s Neck. Journal of Biomimetics, Biomaterials and Biomedical Engineering Trans Tech Publications Ltd, Switzerland. 2020;46:52-59. ISSN: 2296-9845.

Unuane D, Velkeniers B, Anckaert E, et al. Thyroglobulin autoantibodies: is there any added value in the detection of thyroid autoimmunity in women consulting for fertility treatment? Thyroid. 2013;23:1022-1028.

Roberts J, Jenkins C, Wilson R, et al. Recurrent miscarriage is associated with increased numbers of CD5/20 positive lymphocytes and an increased incidence of thyroid antibodies Eur J Endocrinol. 1996;134:84-86.

Poppe K, Glinoer D, Tournaye H, et al. Impact of the ovarian hyperstimulmation syndrome on thyroid function Thyroid. 2008;18:801-802.

Subclinical hypothyroidism in the infertile female population: a guideline. Practice Committee of the American Society for Reproductive Medicine Fertil Steril. 2015; 104:545-555.

Kutteh WH, Schoolcraft WB, Scott Jr RT. Antithyroid antibodies do not affect pregnancy outcome in women undergoing assisted reproduction Hum Reprod. 1999; 14:2886-2890.

Tuncay G, Karaer A, Coskun EI, et al. The impact of thyroid-stimulating hormone levels in euthyroid women on intrauterine insemination outcome BMC Wom Health. 2018;18:51. DOI:10.1186/s12905-018-0541-0