Endocrine Markers of Fertility Potential in Reproductive Age Women with Idiopathic Hyperprolactinemia

Main Article Content

Alina Valerievna Atalyan
Leonid Fedorovich Shelokhov
Lyubov Ilinichna Kolesnikova

Abstract

Background: Hyperprolactinemia (HP) is a common endocrine gynecological disorder in women of reproductive age manifested with menstrual irregularity and sterility subfertility among the majority of women with this disorder.

Objective: The aim of this study was to assess the endocrinal markers of inferility in premenopausal women with idiopathic hyperprolactinemia.

Materials and Metahodology: The study included 82 women: 27 healthy women, 22 fertile women with idiopathic HP and 33 patients with endocrine sub fertility with idiopathic HP.  All women underwent a standard history taking, clinical examinations.  Lab tests were performed in all women and included the detection of the concentrations of prolactin, thyroid-stimulating hormone, thyroxine, triiodothyronine, cortisol, gonadotrophic hormones, testosterone, and estradiol by ELISA method.

 

Results: The study results demonstrated that subfertile women with HP are characterized by an increase of follicle-stimulating hormone and free triiodothyronine and a decrease of estradiol and cortisol when compared with fertile patients with HP and Healthy patients.

Conclusion: The better glucocorticoid and ovarian function of fertile women with HP supposed to be an essential issue in their reproductive ability.

Keywords:
Prolactin, gonadotropins, thyroid-stimulating hormone, thyroid hormones, cortisol, sex steroids, idiopathic hyperprolactinemia, endocrine infertility.

Article Details

How to Cite
Atalyan, A. V., Shelokhov, L. F., & Kolesnikova, L. I. (2020). Endocrine Markers of Fertility Potential in Reproductive Age Women with Idiopathic Hyperprolactinemia. Journal of Pharmaceutical Research International, 32(23), 71-77. https://doi.org/10.9734/jpri/2020/v32i2330790
Section
Original Research Article

References

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Pałubska S, Adamiak-Godlewska A, Winkler I, Romanek-Piva K, Rechberger T, Gogacz M. Hyperprolactinaemia - a problem in patients from the reproductive period to the menopause // Przeglad menopauzalny = Menopause review. 2017;16(1):1–7.

Shrestha S, Neupane S, Gautam N, Dubey RK, Jha AC, Doshi NR, Jayan A. Association of Thyroid Profile and Prolactin Level in Patient with Secondary Amenorrhea // The Malaysian journal of medical sciences : MJMS. 2016;23(5):51–56.

Suturina LV, Atalyan AV, Lazareva LM, Sholokhov LF, Rashidova MA, Kolesnikova LI. Infertility in women with idiopathic hyperprolactinemia is associated with oxidative stress // Reproductive sciences. 2019;26(1):281.

Adamyan LV, Andreeva EN, Artymuk NV, Belokrinickaya TE, Korzhenkova GP, Protasova AE, Rozhkova NI, Suturina LV, Filippov OS. BenignDysplasiaoftheBreast//Russian Journal of Human Reproduction. 2018;24(6):803-826.

Adamyan LV, Artymuk NV, Belokrinickaya TE, Petruhin VA, Smol'nova TYU, Suturina LV, Tetruashvili NK, Filippov OS, CHechneva MA, SHmakov RG. Miscarriage in early pregnancy: diagnosis and management tactics//Russian Journal of Human Reproduction. 2018;24(6):338-357.

Soto-Pedre E, Newey PJ, Bevan JS, Leese GP. Morbidity and mortality in patients with hyperprolactinaemia: the PROLEARS study // Endocrine connections. 2017;6(8):580–588.

Darzhaev ZYu, Atalyan AV, Rinchindorzhieva MP, Suturina LV. The frequency of infertility in marriage among the urban and countryfemale population of the Republic of Buryatia: the results of a population study // Fundamental and clinical medicine. 2017;2(4):14–21.

Soto-Pedre E, Newey PJ, Bevan JS, Greig N, Leese GP. The epidemiology of hyperprolactinaemia over 20 years in the Tayside region of Scotland: The Prolactin Epidemiology, Audit and Research Study (PROLEARS) // Clinical endocrinology. 2017;86(1): 60–67.

Lee DY, Oh YK, Yoon BK, Choi D. Prevalence of hyperprolactinemia in adolescents and young women with menstruation-related problems // American journal of obstetrics and gynecology. 2012;206(3):213:1-5.

Malik AA, Aziz F, Beshyah SA, Aldahmani KM. Aetiologies of Hyperprolactinaemia: A retrospective analysis from a tertiary healthcare centre // Sultan Qaboos University medical journal. 2019;19(2):129-134.

Melmed S, Casanueva FF, Hoffman AR, Kleinberg DL, Montori VM, Schlechte JA, Wass JAH. Diagnosis and treatment of hyperprolactinemia: an Endocrine Society clinical practice guideline // The Journal of clinical endocrinology and metabolism. 2011;96(2):273–288.

Samperi I, Lithgow K, Karavitaki N. Hyperprolactinaemia // Journal of clinical medicine. 2019;8:12.

Grattan DR. 60 YEARS OF NEUROENDOCRINOLOGY: The hypothalamo-prolactin axis // The Journal of endocrinology. 2015;226(2):101-22.

Bernard V, Young J, Chanson P, Binart N. New insights in prolactin: pathological implications // Nature reviews. Endocrinology. 2015;11(5):265–275.

Bassey IE, Udoh AE, Essien OE, Isong IKP, Gali RM, Archibong EE. Thyroid hormones and prolactin levels in infertile women in southern Nigeria // Journal of clinical and diagnostic research : JCDR. 2015;9(3):13-5.

Alpañés M, Sanchón R, Martínez-García MÁ, Martínez-Bermejo E, Escobar-Morreale HF. Prevalence of hyperprolactinaemia in female premenopausal blood donors // Clinical endocrinology. 2013;79(4):545–549.Barren marriage: versions and contraversions / Edited by V. E. Radzinsky. M: GEOTAR-Media. 2018;404.

Pałubska S, Adamiak-Godlewska A, Winkler I, Romanek-Piva K, Rechberger T, Gogacz M. Hyperprolactinaemia - a problem in patients from the reproductive period to the menopause // Przeglad menopauzalny = Menopause review. 2017;16(1):1–7.

Shrestha S, Neupane S, Gautam N, Dubey RK, Jha AC, Doshi NR, Jayan A. Association of Thyroid Profile and Prolactin Level in Patient with Secondary Amenorrhea // The Malaysian journal of medical sciences : MJMS. 2016;23(5):51–56.

Suturina LV, Atalyan AV, Lazareva LM, Sholokhov LF, Rashidova MA, Kolesnikova LI. Infertility in women with idiopathic hyperprolactinemia is associated with oxidative stress // Reproductive sciences. 2019;26(1):281.

Adamyan LV, Andreeva EN, Artymuk NV, Belokrinickaya TE, Korzhenkova GP, Protasova AE, Rozhkova NI, Suturina LV, Filippov OS. BenignDysplasiaoftheBreast//Russian Journal of Human Reproduction. 2018;24(6):803-826.

Adamyan LV, Artymuk NV, Belokrinickaya TE, Petruhin VA, Smol'nova TYU, Suturina LV, Tetruashvili NK, Filippov OS, CHechneva MA, SHmakov RG. Miscarriage in early pregnancy: diagnosis and management tactics//Russian Journal of Human Reproduction. 2018;24(6):338-357.

Soto-Pedre E, Newey PJ, Bevan JS, Leese GP. Morbidity and mortality in patients with hyperprolactinaemia: the PROLEARS study // Endocrine connections. 2017;6(8):580–588.

Darzhaev ZYu, Atalyan AV, Rinchindorzhieva MP, Suturina LV. The frequency of infertility in marriage among the urban and countryfemale population of the Republic of Buryatia: the results of a population study // Fundamental and clinical medicine. 2017;2(4):14–21.

Soto-Pedre E, Newey PJ, Bevan JS, Greig N, Leese GP. The epidemiology of hyperprolactinaemia over 20 years in the Tayside region of Scotland: The Prolactin Epidemiology, Audit and Research Study (PROLEARS) // Clinical endocrinology. 2017;86(1): 60–67.

Lee DY, Oh YK, Yoon BK, Choi D. Prevalence of hyperprolactinemia in adolescents and young women with menstruation-related problems // American journal of obstetrics and gynecology. 2012;206(3):213:1-5.

Malik AA, Aziz F, Beshyah SA, Aldahmani KM. Aetiologies of Hyperprolactinaemia: A retrospective analysis from a tertiary healthcare centre // Sultan Qaboos University medical journal. 2019;19(2):129-134.

Melmed S, Casanueva FF, Hoffman AR, Kleinberg DL, Montori VM, Schlechte JA, Wass JAH. Diagnosis and treatment of hyperprolactinemia: an Endocrine Society clinical practice guideline // The Journal of clinical endocrinology and metabolism. 2011;96(2):273–288.

Samperi I, Lithgow K, Karavitaki N. Hyperprolactinaemia // Journal of clinical medicine. 2019;8:12.

Grattan DR. 60 YEARS OF NEUROENDOCRINOLOGY: The hypothalamo-prolactin axis // The Journal of endocrinology. 2015;226(2):101-22.

Bernard V, Young J, Chanson P, Binart N. New insights in prolactin: pathological implications // Nature reviews. Endocrinology. 2015;11(5):265–275.

Bassey IE, Udoh AE, Essien OE, Isong IKP, Gali RM, Archibong EE. Thyroid hormones and prolactin levels in infertile women in southern Nigeria // Journal of clinical and diagnostic research : JCDR. 2015;9(3):13-5.

Alpañés M, Sanchón R, Martínez-García MÁ, Martínez-Bermejo E, Escobar-Morreale HF. Prevalence of hyperprolactinaemia in female premenopausal blood donors // Clinical endocrinology. 2013;79(4):545–549.