Effects of 6-Weeks Moderate Intensity Aerobic Exercise on CD4 Count, Bone Mineral Density and Weight of People Living with HIV/AIDS in Alex-Ekwueme Federal University Teaching Hospital Ebonyi State

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Asogwa, Eucharia Ijego
Obeagu, Emmanuel Ifeanyi
Ekine, Rupee Suoton
Asogwa, Okwudilichukwu Okwy
Amaeze, Augustine Amaeze
Amaeze, Florence Ngozi
Kalu, Ochie
Orizu, Ifeoma Ada
Abraham, John Chukwuebuka
Odochi, Ogbu Chukwu


The main aim of this study was to find out the effects of 6 weeks moderate intensity aerobic exercises on CD4 count, bone mineral density and weight of people living with HIV/AIDS in Alex-Ekwueme Federal University Teaching Hospital, Ebonyi State. The study adopted experimental research design. The study was carried out form year 2019-February 2020. The population of the study was 40 HIV/AIDS patients that attended HIV clinics at AE-FUTHA which formed the sample size after two subjects declined from the control group in the study. Simple random sampling technique was adopted for the study. Flowcytometery (Partec Cyflow counter) Germany, Heel Densitometer (X-rite 331C), and Omron BF 400 were the instrument used for data collection of CD4 counts, BMD and weight respectively. Mean, standard deviation and ANCOVA were used to analyze the data obtained.  The instruments were not validated because they are standard. The reliability coefficient obtained from the pilot study was 0.848, 0.835 and 0.994 for CD4, BMD and WEIGHT respectively. The major findings revealed that MIAE had positive effect on CD4 counts and BMD but negative effect on weight.

Moderate intensity aerobic exercise, CD4 count, BMD and weight, HIV.

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How to Cite
Ijego, A. E., Ifeanyi, O. E., Suoton, E. R., Okwy, A. O., Amaeze, A. A., Ngozi, A. F., Ochie, K., Ada, O. I., Chukwuebuka, A. J., & Chukwu, O. O. (2020). Effects of 6-Weeks Moderate Intensity Aerobic Exercise on CD4 Count, Bone Mineral Density and Weight of People Living with HIV/AIDS in Alex-Ekwueme Federal University Teaching Hospital Ebonyi State. Journal of Pharmaceutical Research International, 32(23), 13-22. https://doi.org/10.9734/jpri/2020/v32i2330784
Original Research Article


O'Brien K, Nixon S, Tynan AM, Glazier RH. Effectiveness of aerobic exercise in adults living with HIV/AIDS: Systematic review. Med Sci Sports Exerc. 2004;36(10):1659-66.

American Physical Therapy Association. Guide to physical Therapist practice, 2nd ed.Phys Ther. 2001;81:9–744.

Terry L, Sprinz E, Ribeiro JP. Moderate and high intensity exercise training in HIV-1 seropositive individuals: A randomized trial. Int J Sports Med. 2006;20:142- 146.

Ciccolo JT, Jowers EM, Bartholomew JB. The benefits of exercise training for quality of life in HIV/AIDS in the Post-HAART Era (1st ed). Comprehensive Clinical Psychiatry. 2004;34(8):487-99.

Schlenzig C, Jager H, Rieder H. Supervised physical exercise leads to psychological and immunological improvement in pre-AIDS patients. Proceedings of the 5th International AIDS Conference, Montreal, Canada; 1989.

Wallace LS, Ballard JE. Osteoporosis and fracture risk in elderly women. Journal of clinical Endocrinology and Metabolism. 2000;8(1):4118–4124.

Kanis JA, Johnell A, Oden A, Dawson C, Laet DC, Jonsson B. Ten year probabilities of osteoporotic fractures according to BMD and diagnostic thresholds. National Library Medicine; 2001. Available:https://www.ncbi.nlm.nih.gov

Kisner C, Colby LA. Therapeutic exercise foundations and techniques. 6th ed: Arch street Philadephia, PA. 2012;19103. Available:http://davisplus.fadavis.com

Guehi C, Badjé A, Gabillard D, Ouattara E, Koulé SO, Moh R, Ekouevi D, Ahibo H, N’Takpé JB, Menan K, Deschamps N, Lecarrou J, Eholié S, Anglaret X, Danel C. High prevalence of being overweight and obese HIV‑infected persons, before and after 24 months on early ART in the ANRS 12136 Temprano Trial. AIDS Res Ther. 2016;12(13). DOI: 10.1186/s12981-016-0094-y

Department of Infectious Diseases, Treichville Hospital, Abidjan, Côte d’Ivoire.

Mashinya F, Alberts M, Colebunders R, Geertruyden VJP. Weight status and associated factors among HIV-infected people on antiretroviral therapy in rural Dikgale, Limpopo, South Africa. Afr J Prm Health Care Fam Med. 2016;8(1):a1230.

Chou R, Huffman LH, Fu R, Smits AK, Korthuis PT. Screening for HIV: A review of the evidence for the U.S. preventive services task force. Annual of Internal Medicine. 2005;143(1):55–73.

Mupere E, Malone L, Zalwango S, Chiunda A, Okwera A, Parraga I. Lean tissue mass wasting is associated with increased risk of mortality among women with pulmonary tuberculosis in urban Uganda. Ann Epidemiol. Uganda. 2012;22:466–73.

Siqiang G. Experimental study of aerobic exercise on the weight loss effect of obese female college students. Biomedical Research, Special Issue: S193-S196. College of Physical Education and Health, Zhaoqing University, Zhaoqing 526061, Guangdong, PR China; 2018.

Mohar D, Dulbarg CS. Statistical power, sample size, and their reporting in randomized controlled trials. JAMA. 1994; 272:122–4.

Pederson BK, Toft AD. Effects of exercise on lymphocytes and cytokines. British Journal of Sports Medicine. 2000;34(4): 246-251.

Baker JV, Peng G, Rapkin J. CD4+ count and risk of non-AIDS diseases following initial treatment for HIV infection. AIDS. 2008;22:841–8.

Maduagwu SM, Sokunbi GO, Bwala MP, Akanbi OA, Jajere AM. Work-related musculoskeletal disorders among self-employed sewing machine operators in Maiduguri, Nigeria. Occup Med Health Aff. 2015;3:219.

Ibeneme CS, Irem OF, Iloanusi IN, Ezuma DA, Ezenwankwo EF, Okere CP, Nnamani OA, Ezeofor NS, Dim RN, Fortwengel G. Impact of physical exercises on immune function, bone mineral density, and quality of life in people living with HIV/AIDS: A systematic review with meta- analysis. BMC Infectious Diseases. 2019;19:340.

Ezema CI, Onwunali AA, Lamina S, Ezugwu UA, Amaeze AA, Nwankwo MJ. Effect of aerobic exercise training on cardiovascular parameters and CD4 cell count of people living with human immunodeficiency virus/acquired immune deficiency syndrome: A randomized controlled trial. BMC Infectious Diseases. 2014;17(5):543–8.

Tiozzo E, Jayaweera D, Rodriguez A, Konefal J, Melillo AB, Adwan S, Chen L, Parvus C, Figueroa M, Hodgson N, Woolger JM, Kanka R, Perry A, Lewis JE. Short-term combined exercise training improves the health of HIV-infected patients. J AIDS HIV Res. 2013;3(5):80–94.

Alghadir, A. H., Aly, F. A., & Gabr, S. A. (2014). Effect of moderate aerobic training on bone metabolism indices among adult humans. Pak J Med Sci., 30(4):840-844.

Aktas S, Ozdil G, Bagis O Guven F. The effects of 8-week aerobic training on body weight among sedentary females. Turkish Journal of Sport and Exercise. 2016;18(2): 113-116.

Suman C. Aerobic exercise programme and reduction in body weight and Body Mass Index (BMI). Galore International Journal of Health Sciences and Research. 2016;1(1):2456-9321.