Therapeutic Interventions of Cardamom in Cancer and Other Human Diseases
Journal of Pharmaceutical Research International,
Page 74-84
DOI:
10.9734/jpri/2020/v32i2230774
Abstract
Cardamom, a dietary phytoproduct, is the most popular spice in the world, and its beneficial health properties are gaining more and more attention. Small cardamom [Elettaria cardamomum (L.) Maton. (Family: Zingiberaceae) ] has been used for traditional therapeutic applications, including the management of asthma, teeth and gum infections, cataracts, nausea, diarrhea and heart, digestive and kidney disorders. Numerous studies have demonstrated the biological activity of cardamom and its polyphenols, including antioxidant, anti-tumor, anti-inflammatory, and metabolic control.1,8-cineole, and its esters, Limonene, α-terpinyl acetates are the most abundant bioactive constituents in cardamom. They are known to be multifunctional compounds that can be efficient in the prevention or treatment of various types of cancers, cardiovascular diseases, chronic inflammatory conditions, digestive disorders, as well as infectious bacterial and fungal diseases. In this review, we summarized the up-to-date research and underlying molecular mechanisms of cardamom and its active components.
Keywords:
- Cardamom
- phytochemicals
- cancer prevention
- anti-inflammatory
- antimicrobial.
How to Cite
Qiblawi, S., Kausar, M. A., Shahid, S. M. A., Saeed, M. and Alazzeh, A. Y. (2020) “Therapeutic Interventions of Cardamom in Cancer and Other Human Diseases”, Journal of Pharmaceutical Research International, 32(22), pp. 74-84. doi: 10.9734/jpri/2020/v32i2230774.
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Verma SK, Jain V, Singh DP. Effect of greater cardamom (Amomum subulatum Roxb.) on blood lipids, fibrinolysis and total antioxidant status in patients with ischemic heart disease. Asian Pacific Journal of Tropical Disease. 2012;2:S739-S743.
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Majdalawieh AF, Carr RI. In vitro investigation of the potential immunomodulatory and anti-cancer activities of black pepper (Piper nigrum) and cardamom (Elettaria cardamomum). J Med Food. 2010;13(2):371-381.
Abdullah, Asghar A, Butt MS, Shahid M, Huang Q. Evaluating the anti-microbial potential of green cardamom essential oil focusing on quorum sensing inhibition of Chromobacterium violaceum. J Food Sci Technol. 2017;54(8):2306-2315.
Amma KP, Sasidharan I, Sreekumar M, Sumathykutty M, Arumughan C. Total antioxidant capacity and change in phytochemicals of four major varieties of cardamom oils during decortication. International Journal of Food Properties. 2015;18(6):1317-1325.
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Hussain T, Bajpai S, Saeed M, Moin A, Alafnan A, Khan M, Kamal MA, Ganash M, Ashraf GM. Potentiating effect of ethnomedicinal plants against proliferation on different cancer cell lines. Curr Drug Metab. 2018;19(7):584-595.
Najm MZ, Akhtar MS, Ahmad I, Sadaf, Mallick MN, Kausar MA, Chattopadhyay S, Ahad A, Zaidi S, Husain SA et al. Mutational analysis of prohibitin--a highly conserved gene in Indian female breast cancer cases. Asian Pac J Cancer Prev. 2012;13(10):5113-5117.
Pratheeshkumar P, Sreekala C, Zhang Z, Budhraja A, Ding S, Son YO, Wang X, Hitron A, Hyun-Jung K, Wang L et al. Cancer prevention with promising natural products: mechanisms of action and molecular targets. Anti-cancer Agents Med Chem. 2012;12(10):1159-1184.
Hashim S, Aboobaker VS, Madhubala R, Bhattacharya RK, Rao AR. Modulatory effects of essential oils from spices on the formation of DNA adduct by aflatoxin B1 in vitro. Nutr Cancer. 1994;21(2):169-175.
Chen C, Kong AN. Dietary chemopreventive compounds and ARE/ EpRE signaling. Free Radic Biol Med. 2004;36(12):1505-1516.
Surh YJ, Kundu JK, Na HK. Nrf2 as a master redox switch in turning on the cellular signaling involved in the induction of cytoprotective genes by some chemopreventive phytochemicals. Planta Med. 2008;74(13):1526-1539.
Das I, Acharya A, Berry DL, Sen S, Williams E, Permaul E, Sengupta A, Bhattacharya S, Saha T. Antioxidative effects of the spice cardamom against non-melanoma skin cancer by modulating nuclear factor erythroid-2-related factor 2 and NF-kappaB signalling pathways. Br J Nutr. 2012;108(6):984-997.
Elguindy NM, Yacout GA, El Azab EF, Maghraby HK. Chemoprotective effect of Elettaria cardamomum against chemically induced hepatocellular carcinoma in rats by inhibiting NF-κB, oxidative stress, and activity of ornithine decarboxylase. South African journal of botany. 2016;105:251-258.
Kim SS, Oh OJ, Min HY, Park EJ, Kim Y, Park HJ, Nam Han Y, Lee SK. Eugenol suppresses cyclooxygenase-2 expression in lipopolysaccharide-stimulated mouse macrophage RAW264.7 cells. Life Sci. 2003;73(3):337-348.
Qiblawi S, Al-Hazimi A, Al-Mogbel M, Hossain A, Bagchi D. Chemopreventive effects of cardamom (Elettaria cardamomum L.) on chemically induced skin carcinogenesis in Swiss albino mice. J Med Food. 2012;15(6):576-580.
Sengupta A, Ghosh S, Bhattacharjee S. Dietary cardamom inhibits the formation of azoxymethane-induced aberrant crypt foci in mice and reduces COX-2 and iNOS expression in the colon. Asian Pac J Cancer Prev. 2005;6(2):118-122.
Elguindy NM, Yacout GA, El Azab EF. Amelioration of DENA-induced oxidative stress in rat kidney and brain by the essential oil of Elettaria cardamomum. Beni-Suef University Journal of Basic and Applied Sciences. 2018;7(3):299-305.
Asamoto M, Ota T, Toriyama-Baba H, Hokaiwado N, Naito A, Tsuda H. Mammary carcinomas induced in human c-Ha-ras proto-oncogene transgenic rats are estrogen-independent, but responsive to d-limonene treatment. Jpn J Cancer Res. 2002;93(1):32-35.
Guo XM, Lu Q, Liu ZJ, Wang LF, Feng BA. [Effects of D-limonene on leukemia cells HL-60 and K562 in vitro]. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2006;14(4):692-695.
Moteki H, Hibasami H, Yamada Y, Katsuzaki H, Imai K, Komiya T. Specific induction of apoptosis by 1,8-cineole in two human leukemia cell lines, but not a in human stomach cancer cell line. Oncol Rep. 2002;9(4):757-760.
Raksamiharja R, Sy K, Novarina A, Sasmito E. Elettaria cardamomum distillate increases cellular immunity in doxorubicin treated rats. Indonesian Journal of Cancer Chemoprevention. 2012;3(3):437-443.
Block RM, Lewis RD, Sheats JB, Fawley J. Cell-mediated immune response to dog pulp tissue altered by eugenol within the root canal. Oral Surg Oral Med Oral Pathol. 1978;45(3):452-463.
Mishra N, Behal K. Chemopreventive activity of some spices against selected cell line. Der Pharm Sin. 2011;2:31-35.
Neeta, B, Archana C. Spices as an Alternative Therapy for Cancer treatment. Systematic reviews in Pharmacy. 2016;26(1):46-56.
Rahman K, Lowe GM. Garlic and cardiovascular disease: A critical review. J Nutr. 2006;136(3):736S-740S.
Nabi R, Alvi SS, Saeed M, Ahmad S, Khan MS. Glycation and HMG-CoA reductase inhibitors: Implication in Diabetes and Associated Complications. Curr Diabetes Rev. 2019;15(3):213-223.
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