Therapeutic Interventions of Cardamom in Cancer and Other Human Diseases
Journal of Pharmaceutical Research International,
Cardamom, a dietary phytoproduct, is the most popular spice in the world, and its beneficial health properties are gaining more and more attention. Small cardamom [Elettaria cardamomum (L.) Maton. (Family: Zingiberaceae) ] has been used for traditional therapeutic applications, including the management of asthma, teeth and gum infections, cataracts, nausea, diarrhea and heart, digestive and kidney disorders. Numerous studies have demonstrated the biological activity of cardamom and its polyphenols, including antioxidant, anti-tumor, anti-inflammatory, and metabolic control.1,8-cineole, and its esters, Limonene, α-terpinyl acetates are the most abundant bioactive constituents in cardamom. They are known to be multifunctional compounds that can be efficient in the prevention or treatment of various types of cancers, cardiovascular diseases, chronic inflammatory conditions, digestive disorders, as well as infectious bacterial and fungal diseases. In this review, we summarized the up-to-date research and underlying molecular mechanisms of cardamom and its active components.
- cancer prevention
How to Cite
Hussain MS, Fareed S, Ansari S, Rahman MA, Ahmad IZ, Saeed M. Current approaches toward production of secondary plant metabolites. J Pharm Bioallied Sci. 2012;4(1):10-20.
Garg G, Sharma S, Dua A, Mahajan R. Antibacterial potential of polyphenol rich methanol extract of Cardamom (Amomum subulatum). J Innov Biol. 2016;3(1):271-275.
Nirmala Menon A. Studies on the volatiles of cardamom (Eletteria cardamomum). Journal of Food Science and Technology (Mysore). 2000;37(4):406-408.
Mahindru SN. Spices in Indian life,(6500 BC-1950 AD); 1982.
Vijayan K, Madhusoodanan K, Radhakrishnan V, Ravindran P. Properties and end-uses of cardamom. In: Cardamom. edn.: CRC Press. 2002;285-299.
Takeda J, De Silva S, Muthuraman P, Rahman SM, Kawet L. Spices in Sri Lanka, India and Bangladesh with special reference to the usages and consumptions. Agri Bull. 2008;93:1-25.
Acharya A, Das I, Singh S, Saha T. Chemopreventive properties of indole-3-carbinol, diindolylmethane and other constituents of cardamom against carcinogenesis. Recent Pat Food Nutr Agric. 2010;2(2):166-177.
Deepa G, Ayesha S, Nishtha K, Thankamani M. Comparative evaluation of various total antioxidant capacity assays applied to phytochemical compounds of Indian culinary spices. International Food Research Journal. 2013;20(4).
Vaidya A, Rathod M. An in vitro study of the immunomodulatory effects of Piper nigrum (black pepper) and Elettaria cardamomum (cardamom) extracts using a murine macrophage cell line. AIJRFANS 2014;8(1):18-27.
Qiblawi S, Dhanarasu S, Faris MA. Chemopreventive effect of cardamom (Elettaria cardamomum L.) Against Benzo(alpha) pyrene-induced Forestomach papillomagenesis in Swiss albino mice. J Environ Pathol Toxicol Oncol. 2015; 34(2):95-104.
Goyal SN, Sharma C, Mahajan UB, Patil CR, Agrawal YO, Kumari S, Arya DS, Ojha S. Protective Effects of Cardamom in Isoproterenol-Induced Myocardial Infarction in Rats. Int J Mol Sci. 2015; 16(11):27457-27469.
Bhattacharjee S, Rana T, Sengupta A. Inhibition of lipid peroxidation and enhancement of GST activity by cardamom and cinnamon during chemically induced colon carcinogenesis in Swiss albino mice. Asian Pac J Cancer Prev. 2007;8(4):578-582.
Jamal A, Javed K, Aslam M, Jafri MA. Gastroprotective effect of cardamom, Elettaria cardamomum Maton. fruits in rats. J Ethnopharmacol. 2006;103(2):149-153.
Verma SK, Jain V, Singh DP. Effect of greater cardamom (Amomum subulatum Roxb.) on blood lipids, fibrinolysis and total antioxidant status in patients with ischemic heart disease. Asian Pacific Journal of Tropical Disease. 2012;2:S739-S743.
al-Zuhair H, el-Sayeh B, Ameen HA, al-Shoora H. Pharmacological studies of cardamom oil in animals. Pharmacol Res. 1996;34(1-2):79-82.
Majdalawieh AF, Carr RI. In vitro investigation of the potential immunomodulatory and anti-cancer activities of black pepper (Piper nigrum) and cardamom (Elettaria cardamomum). J Med Food. 2010;13(2):371-381.
Abdullah, Asghar A, Butt MS, Shahid M, Huang Q. Evaluating the anti-microbial potential of green cardamom essential oil focusing on quorum sensing inhibition of Chromobacterium violaceum. J Food Sci Technol. 2017;54(8):2306-2315.
Amma KP, Sasidharan I, Sreekumar M, Sumathykutty M, Arumughan C. Total antioxidant capacity and change in phytochemicals of four major varieties of cardamom oils during decortication. International Journal of Food Properties. 2015;18(6):1317-1325.
Saeed M, Alshammari FD, Alam MJ, Sarim KM, Ahmad K, Hussain T, Khan M, Kamal MA, Kausar MA, Alkreathy HM, et al. A synopsis on the role of human papilloma virus infection in cervical cancer. Curr Drug Metab. 2018;19(9):798-805.
Saeed M, Faisal SM, Akhtar F, Ahmad S, Alreshidi MM, Kausar MA, Kazmi S, Saeed A, Adnan M, Ashraf GM. Human papillomavirus induced cervical and oropharyngeal cancers: From mechanisms to potential immuno-therapeutic strategies. Curr Drug Metab. 2020;21(3):167-177.
Ahmad S, Khan MY, Rafi Z, Khan H, Siddiqui Z, Rehman S, Shahab U, Khan MS, Saeed M, Alouffi S, et al. Oxidation, glycation and glycoxidation-The vicious cycle and lung cancer. Semin Cancer Biol. 2018;49:29-36.
Hussain T, Bajpai S, Saeed M, Moin A, Alafnan A, Khan M, Kamal MA, Ganash M, Ashraf GM. Potentiating effect of ethnomedicinal plants against proliferation on different cancer cell lines. Curr Drug Metab. 2018;19(7):584-595.
Najm MZ, Akhtar MS, Ahmad I, Sadaf, Mallick MN, Kausar MA, Chattopadhyay S, Ahad A, Zaidi S, Husain SA et al. Mutational analysis of prohibitin--a highly conserved gene in Indian female breast cancer cases. Asian Pac J Cancer Prev. 2012;13(10):5113-5117.
Pratheeshkumar P, Sreekala C, Zhang Z, Budhraja A, Ding S, Son YO, Wang X, Hitron A, Hyun-Jung K, Wang L et al. Cancer prevention with promising natural products: mechanisms of action and molecular targets. Anti-cancer Agents Med Chem. 2012;12(10):1159-1184.
Hashim S, Aboobaker VS, Madhubala R, Bhattacharya RK, Rao AR. Modulatory effects of essential oils from spices on the formation of DNA adduct by aflatoxin B1 in vitro. Nutr Cancer. 1994;21(2):169-175.
Chen C, Kong AN. Dietary chemopreventive compounds and ARE/ EpRE signaling. Free Radic Biol Med. 2004;36(12):1505-1516.
Surh YJ, Kundu JK, Na HK. Nrf2 as a master redox switch in turning on the cellular signaling involved in the induction of cytoprotective genes by some chemopreventive phytochemicals. Planta Med. 2008;74(13):1526-1539.
Das I, Acharya A, Berry DL, Sen S, Williams E, Permaul E, Sengupta A, Bhattacharya S, Saha T. Antioxidative effects of the spice cardamom against non-melanoma skin cancer by modulating nuclear factor erythroid-2-related factor 2 and NF-kappaB signalling pathways. Br J Nutr. 2012;108(6):984-997.
Elguindy NM, Yacout GA, El Azab EF, Maghraby HK. Chemoprotective effect of Elettaria cardamomum against chemically induced hepatocellular carcinoma in rats by inhibiting NF-κB, oxidative stress, and activity of ornithine decarboxylase. South African journal of botany. 2016;105:251-258.
Kim SS, Oh OJ, Min HY, Park EJ, Kim Y, Park HJ, Nam Han Y, Lee SK. Eugenol suppresses cyclooxygenase-2 expression in lipopolysaccharide-stimulated mouse macrophage RAW264.7 cells. Life Sci. 2003;73(3):337-348.
Qiblawi S, Al-Hazimi A, Al-Mogbel M, Hossain A, Bagchi D. Chemopreventive effects of cardamom (Elettaria cardamomum L.) on chemically induced skin carcinogenesis in Swiss albino mice. J Med Food. 2012;15(6):576-580.
Sengupta A, Ghosh S, Bhattacharjee S. Dietary cardamom inhibits the formation of azoxymethane-induced aberrant crypt foci in mice and reduces COX-2 and iNOS expression in the colon. Asian Pac J Cancer Prev. 2005;6(2):118-122.
Elguindy NM, Yacout GA, El Azab EF. Amelioration of DENA-induced oxidative stress in rat kidney and brain by the essential oil of Elettaria cardamomum. Beni-Suef University Journal of Basic and Applied Sciences. 2018;7(3):299-305.
Asamoto M, Ota T, Toriyama-Baba H, Hokaiwado N, Naito A, Tsuda H. Mammary carcinomas induced in human c-Ha-ras proto-oncogene transgenic rats are estrogen-independent, but responsive to d-limonene treatment. Jpn J Cancer Res. 2002;93(1):32-35.
Guo XM, Lu Q, Liu ZJ, Wang LF, Feng BA. [Effects of D-limonene on leukemia cells HL-60 and K562 in vitro]. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2006;14(4):692-695.
Moteki H, Hibasami H, Yamada Y, Katsuzaki H, Imai K, Komiya T. Specific induction of apoptosis by 1,8-cineole in two human leukemia cell lines, but not a in human stomach cancer cell line. Oncol Rep. 2002;9(4):757-760.
Raksamiharja R, Sy K, Novarina A, Sasmito E. Elettaria cardamomum distillate increases cellular immunity in doxorubicin treated rats. Indonesian Journal of Cancer Chemoprevention. 2012;3(3):437-443.
Block RM, Lewis RD, Sheats JB, Fawley J. Cell-mediated immune response to dog pulp tissue altered by eugenol within the root canal. Oral Surg Oral Med Oral Pathol. 1978;45(3):452-463.
Mishra N, Behal K. Chemopreventive activity of some spices against selected cell line. Der Pharm Sin. 2011;2:31-35.
Neeta, B, Archana C. Spices as an Alternative Therapy for Cancer treatment. Systematic reviews in Pharmacy. 2016;26(1):46-56.
Rahman K, Lowe GM. Garlic and cardiovascular disease: A critical review. J Nutr. 2006;136(3):736S-740S.
Nabi R, Alvi SS, Saeed M, Ahmad S, Khan MS. Glycation and HMG-CoA reductase inhibitors: Implication in Diabetes and Associated Complications. Curr Diabetes Rev. 2019;15(3):213-223.
Parveen K, Siddiqui WA, Arif JM, Kuddus M, Shahid SMA, Kausar MA. Evaluation of vegetables and fish oils for the attenuation of diabetes complications. Cell Mol Biol (Noisy-le-grand). 2019;65(7):38-45.
Lahlou S, Figueiredo AF, Magalhaes PJ, Leal-Cardoso JH. Cardiovascular effects of 1,8-cineole, a terpenoid oxide present in many plant essential oils, in normotensive rats. Can J Physiol Pharmacol. 2002; 80(12):1125-1131.
Hemalatha KL, Prince PS. Preventive effects of zingerone on altered lipid peroxides and nonenzymatic antioxidants in the circulation of isoproterenol-induced myocardial infarcted rats. J Biochem Mol Toxicol. 2015;29(2):63-69.
Hassan MQ, Akhtar MS, Akhtar M, Ali J, Haque SE, Najmi AK. Edaravone protects rats against oxidative stress and apoptosis in experimentally induced myocardial infarction: Biochemical and ultrastructural evidence. Redox Rep. 2015;20(6):275-281.
Bandyopadhyay D, Chattopadhyay A, Ghosh G, Datta AG. Oxidative stress-induced ischemic heart disease: Protection by antioxidants. Curr Med Chem. 2004; 11(3):369-387.
Parveen K, Siddiqui WA, Kausar MA, Kuddus M, Shahid SMA, Arif JM. Diabetic nephropathy-a major macrovascular complication. International Journal of Pharmaceutical Research & Allied Sciences. 2016;5(4).
Govindarajan VS, Narasimhan S, Raghuveer KG, Lewis YS. Cardamom--production, technology, chemistry, and quality. Crit Rev Food Sci Nutr. 1982; 16(3):229-326.
Nagashree S, Archana KK, Srinivas P, Srinivasan K, Sowbhagya HB. Anti-hypercholesterolemic influence of the spice cardamom (Elettaria cardamomum) in experimental rats. J Sci Food Agric. 2017; 97(10):3204-3210.
Suneetha WJ, Krishnakantha TP. Cardamom extract as inhibitor of human platelet aggregation. Phytother Res. 2005; 19(5):437-440.
Prasad S, Sung B, Aggarwal BB. Age-associated chronic diseases require age-old medicine: Role of chronic inflammation. Prev Med. 2012;54(Suppl):S29-37.
Nasef NA, Mehta S, Ferguson LR. Susceptibility to chronic inflammation: an update. Arch Toxicol. 2017;91(3):1131-1141.
Saeed M, Kausar MA, Singh R, Siddiqui AJ, Akhter A. The role of glyoxalase in glycation and carbonyl stress induced metabolic disorders. Curr Protein Pept Sci; 2020.
Song YA, Park YL, Kim KY, Chung CY, Lee GH, Cho DH, Ki HS, Park KJ, Cho SB, Lee WS et al. Black tea extract prevents lipopolysaccharide-induced NF-kappaB signaling and attenuates dextran sulfate sodium-induced experimental colitis. BMC Complement Altern Med. 2011;11:91.
Tak PP, Firestein GS. NF-kappaB: A key role in inflammatory diseases. J Clin Invest. 2001;107(1):7-11.
Reuter S, Gupta SC, Chaturvedi MM, Aggarwal BB. Oxidative stress, inflammation, and cancer: How are they linked? Free Radic Biol Med. 2010;49(11): 1603-1616.
Li W, Khor TO, Xu C, Shen G, Jeong WS, Yu S, Kong AN. Activation of Nrf2-antioxidant signaling attenuates NFkappaB-inflammatory response and elicits apoptosis. Biochem Pharmacol. 2008;76(11):1485-1489.
Rodrigues TG, Fernandes A, Jr., Sousa JP, Bastos JK, Sforcin JM. In vitro and in vivo effects of clove on pro-inflammatory cytokines production by macrophages. Nat Prod Res. 2009;23(4):319-326.
Choi CY, Park KR, Lee JH, Jeon YJ, Liu KH, Oh S, Kim DE, Yea SS. Isoeugenol suppression of inducible nitric oxide synthase expression is mediated by down-regulation of NF-kappaB, ERK1/2, and p38 kinase. Eur J Pharmacol. 2007;576(1-3): 151-159.
Han X, Parker TL. Cardamom (Elettaria cardamomum) essential oil significantly inhibits vascular cell adhesion molecule 1 and impacts genome-wide gene expression in human dermal fibroblasts. Cogent Medicine. 2017;4(1):1308066.
Zhao C, Sun J, Fang C, Tang F. 1,8-cineol attenuates LPS-induced acute pulmonary inflammation in mice. Inflammation. 2014; 37(2):566-572.
Juergens UR. Anti-inflammatory properties of the monoterpene 1.8-cineole: Current evidence for co-medication in inflammatory airway diseases. Drug Res (Stuttg). 2014; 64(12):638-646.
Santos FA, Silva RM, Campos AR, De Araujo RP, Lima Junior RC, Rao VS. 1,8-cineole (eucalyptol), a monoterpene oxide attenuates the colonic damage in rats on acute TNBS-colitis. Food Chem Toxicol. 2004;42(4):579-584.
Yadav VR, Prasad S, Sung B, Kannappan R, Aggarwal BB. Targeting inflammatory pathways by triterpenoids for prevention and treatment of cancer. Toxins (Basel). 2010;2(10):2428-2466.
Bruzzo J, Chiarella P, Fernandez G, Bustuoabad OD, Ruggiero RA. [Systemic inflammation and experimental cancer in a murine model]. Medicina (B Aires). 2007; 67(5):469-474.
Romano M, Vitaglione P, Sellitto S, D’Argenio G. Nutraceuticals for protection and healing of gastrointestinal mucosa. Curr Med.Chem. 2012;19(1) 109-17.
Santos FA, Rao VS. 1,8-cineol, a Food Flavoring Agent, Prevents Ethanol-Induced Gastric Injury in Rats. Dig. Dis .Sci. 2001; 46(2):331-337 .
Tajkarimi M, Ibrahim SA, Cliver D. Antimicrobial herb and spice compounds in food. Food control. 2010;21(9):1199-1218.
El Malti J, Mountassif D, Amarouch H: Anti-microbial activity of Elettaria cardamomum: Toxicity, biochemical and histological studies. Food chemistry. 2007;104(4): 1560-1568.
Singh G, Kiran S, Marimuthu P, Isidorov V, Vinogorova V. Antioxidant and anti-microbial activities of essential oil and various oleoresins of Elettaria cardamomum (seeds and pods). Journal of the Science of Food and Agriculture. 2008; 88(2):280-289.
Karthy E, Ranjitha P, Mohankumar A. Anti-microbial potential of plant seed extracts against multidrug resistant methicillin resistant Staphylococcus aureus (MDR-MRSA). International Journal of Biology. 2009;1(1):34.
Arora DS, Kaur GJ. Antibacterial activity of some Indian medicinal plants. Journal of natural medicines. 2007;61(3):313-317.
Chen N, Chang CC, Ng CC, Wang CY, Shyu YT, Chang TL. Antioxidant and antimicrobial activity of Zingiberaceae plants in Taiwan. Plant Foods. Hum. Nutr. 2008;63(1):15–20
Sandasi M, Leonard C, Viljoen A. The effect of five common essential oil components on Listeria monocytogenes biofilms. Food control. 2008;19(11):1070-1075.
Bano S, Ahmad N, Sharma A. Phytochemical screening and evaluation of anti-microbial and anti-oxidant activity of Elettaria cardamom (Cardamom). Journal of Applied and Natural Science. 2016;8(4): 1966-1970.
Mejdi S, Emira N, Ameni D, Guido F, Mahjoub A, Madiha A-s, Abdulbasit A-s. Chemical composition and anti-microbial activities of Elettaria cardamomum L.(Manton) essential oil: A high activity against a wide range of food borne and medically important bacteria and fungi. J Chem Biol Phy Sci Sec A. 2015;6:248-259.
Radhakrishnan V, Kuruba A, Dwivedi SP, Prasad T. Formulated natural plant extracts from nutmeg and cardamom show antifungal activity against clinical isolates of candida albicans and affects cellular morphology and ergosterol. multidisciplinary approaches for studying and combating microbial pathogens. 2015; 85.
Abstract View: 479 times
PDF Download: 276 times