Pilot Study: Assessment of Drug-Food and Drug-Drug Interactions in the Outpatient Settings
Journal of Pharmaceutical Research International,
Page 58-63
DOI:
10.9734/jpri/2020/v32i2130752
Abstract
Background: A drug-drug interaction arises when the pharmacologic effect of a medication is changed by the action of other medication causing unexpected clinical effects. Drug-drug interactions are widely known but the identification of the consequences of food and drug interactions has been growing slowly.
Aim: The present study aims to describe the occurrence of drug –food and drug-drug interactions in the outpatient settings in Riyadh city.
Methodology: A retrospective study was piloted in Riyadh city. The prescriptions were reviewed to identify potential drug - food and drug–drug interactions using Drug Interactions Checker.
Results: About 16.16% of the prescriptions included a drug - drug interaction. The most frequent interaction was the interaction between ciprofloxacin and metronidazole (25.00%) that is a minor interaction. Regarding drug – food interactions there were 40 interactions, the majority of these interactions were moderate. The most common drug - food interactions were metronidazole with food (20.00%) that is a major interaction.
Conclusion: Drug interactions with other drugs or with foods are common. These interactions could have a beneficial or a harmful effect. Physicians and pharmacists should use programs that detects the drug interactions.
Keywords:
- Drug-drug interactions
- drug–food Interactions
- outpatient
How to Cite
References
Ruths S, Viktil KK, Blix HS. Klassifisering av legemiddelrelaterte problemer [Classification of drug-related problems]. Tidsskr Nor Laegeforen. 2007;127(23): 3073‐3076.
Krähenbühl-Melcher A, Schlienger RL, Lampert M, Haschke M, Drewe J, Krähenbühl S. Drug-related problems in hospitals: A review of the recent literature. Drug Saf. 2007;30(5):379-407.
Lee SI. Drug interaction: focusing on response surface models. Korean J Anesthesiol. 2010;58(5):421-434.
Magro L, Moretti U, Leone R. Epidemiology and characteristics of adverse drug reactions caused by drug-drug interactions. Expert Opin Drug Saf. 2012;11(1):83-94.
Huang J, Niu C, Green CD, Yang L, Mei H, Han JD. Systematic prediction of pharmacodynamic drug-drug interactions through protein-protein-interaction network. PLoS Comput Biol. 2013;9(3):e1002998.
Huang SM, Temple R, Throckmorton DC, Lesko LJ. Drug interaction studies: Study design, data analysis, and implications for dosing and labeling. Clin Pharmacol Ther. 2007;81(2):298–304.
Strandell J, Bate A, Lindquist M, Edwards IR. Drug–drug interactions – A preventable patient safety issue? Br J Clin Pharmacol. 2008;65(1):144–6.
Becker ML, Kallewaard M, Caspers PW, Visser LE, H. G. Leufkens HG, Stricker BH. Hospitalisations and emergency department visits due to drug-drug interactions: A literature review. Pharmacoepidemiol Drug Saf. 2007;16(6): 641–51.
Cascorbi I. Drug interactions--principles, examples and clinical consequences. Dtsch Arztebl Int. 2012;109(33-34):546–556.
Bushra R, Aslam N, Khan AY. Food-drug interactions. Oman Med J. 2011;26(2): 77‐83.
Palleria C, Di Paolo A, Giofrè C, Caglioti C, Leuzzi G, Siniscalchi A, et al. Pharmacokinetic drug-drug interaction and their implication in clinical management. J Res Med Sci. 2013;18(7):601–610.
Bertsche T, Pfaff J, Schiller P, Kaltschmidt J, Pruszydlo MG, Stremmel W et al. Prevention of adverse drug reactions in intensive care patients by personal intervention based on an electronic clinical decision support system. J Intensive Care Med. 2010;36(4): 665-72.
Moore N, Biour M, Paux G, Loupi E, Begaud B, Boismare F, et al. Adverse drug reaction monitoring: Doing it the French way. Lancet. 1985;2(8463):1056–8.
Ötles S, Senturk A. Food and drug Interactions: A general review. Acta Sci Pol Technol Aliment. 2014;13(1):89‐102.
Drug Interactions Checker - For Drugs, Food & Alcohol; 2020.
Available:https://www.drugs.com/drug_interactions.html
Retrieved 23 August 2020.
Heringa M, Floor A, Meijer WM, De Smet PA, Bouvy ML. Nature and management of duplicate medication alerts. J Am Med Inform Assoc. 2015;22(4):831-837.
Karas SJr. The potential for drug interactions. Ann Emerg Med. 1981;10(12): 627‐630.
Farooqui R, Hoor T, Karim N, Muneer M. Potential drug-drug interactions among patients prescriptions collected from medicine out-patient setting. PaK J Med Sci. 2018;34(1):144–148.
Khandeparkar A, Rataboli PV. A study of harmful drug-drug interactions due to polypharmacy in hospitalized patients in Goa Medical College. Perspect Clin Res. 2017;8(4):180–186.
Ahmed NJ, Alamri ST, Balaha M, Al Matrafi B, Haseeb A, Hassali MA, et al. Evaluation of prescriptions drug-drug interactions in a public hospital in Al-Kharj, Saudi Arabia. Lat Am J Pharm. 2020;39(1): 203-207.
Medina-Barajas F, Vázquez-Méndez E, Pérez-Guerrero EE, Sánchez-López VA, Hernández-Cañaveral II, Huerta-Olvera SG. Pilot study: Evaluation of potential drug-drug interactions in hospitalized pediatric patients. Pediatr Neonatol. 2020; 61(3):279-289.
Werk R, Schneider L. Ciprofloxacin in combination with metronidazole. Infection. 1988;16(4):257‐260.
Solomkin JS, Mazuski JE, Bradley JS, Rodvold KA, Goldstein EJ, Baron EJ, et al. Diagnosis and management of complicated intra-abdominal infection in adults and children: Guidelines by the surgical infection society and the infectious diseases society of America. Clin Infect Dis. 2010;50(2):133–164.
Finegold SM. Metronidazole. Ann Intern Med. 1980;93(4):585-587.
Pápai K, Budai M, Ludányi K, Antal I, Klebovich I. In vitro food-drug interaction study: Which milk component has a decreasing effect on the bioavailability of ciprofloxacin? J Pharm Biomed Anal. 2010; 52(1):37-42.
Akinleye MO, Coker HA, Chukwuani CM, Adeoye AW. Effect of Five Alive fruit juice on the dissolution and absorption profiles of ciprofloxacin. Nig QJ Hosp Med. 2007; 17(1):53-57.
Schmidt LE, Dalhoff K. Food-drug interactions. Drugs. 2002;62(10):1481-1502.
Nekvindová J, Anzenbacher P. Ceska Slov Farm. 2007;56(4):165-173.
-
Abstract View: 319 times
PDF Download: 224 times
