Anti-inflammatory and Antioxidant Potential of Hyaluronic Acid Mediated Zinc Nanoparticles
Journal of Pharmaceutical Research International,
Page 33-37
DOI:
10.9734/jpri/2020/v32i2030727
Abstract
Aim: The aim of the study is to interpret the hyaluronic acid mediated with zinc oxide nanoparticle and its anti-inflammatory and antioxidant activity.
Introduction: Hyaluronic acid has a role as ‘physiological selector’ for spermatozoa prior to intracy to plasmic sperm injection (icsi). They are mostly seen in the synovial joints and act as a shock absorber. The objective of this study is to analyse the results achievable by the introduction of a routine HA. Hyaluronic acid is an immune neutral polysaccharide that is ubiquitous in the human body, and it is crucial for many cellular and tissue functions. Nanoparticles are the compounds which respond to the applied magnetic fields, magnetic separation labelled cells, therapeutic drug, gene and radionuclide delivery and other biological entities.
Materials and Methods: Hyaluronic acid mediated with zno nanoparticles were evaluated for its anti inflammatory activity and antioxidant potential using photometry analysis.
Results and Discussion: Zinc nanoparticles shows a higher efficiency of antibacterial activity, but sublethal concentration causes adverse effects and results in increased biofilm formation of V. cholerae Hyaluronic acid mediated zinc oxide nanoparticle show good result in anti inflammatory activity as well as in antioxidant activity. The biosynthesis of the nanoparticle was done by addition of hyaluronic acid with zinc nanoparticles in a scarese amount. This was kept in the orbital shaker, hence they take a long time for the synthesis. The colour change was observed, hence the synthesized nanoparticles proceeded with the anti-inflammatory and antioxidant tests.
Keywords:
- Anti inflammatory
- hyaluronic acid
- anti-oxidant
- anti-microbial
How to Cite
References
Salem W, Leitner DR, Zingl FG, et al., Antibacterial activity of silver and zinc nanoparticles against Vibrio cholerae and enterotoxic Escherichia coli. Int J Med Microbiol. 2015;305:85–95.
Nagajyothi PC, Cha SJ, Yang IJ, et al., Antioxidant and anti-inflammatory activities of zinc oxide nanoparticles synthesized using Polygala tenuifolia root extract. J Photochem Photobiol B. 2015;146:10–17.
Hackenberg S, Scherzed A, Technau A, et al., Cytotoxic, genotoxic and pro-inflammatory effects of zinc oxide nanoparticles in human nasal mucosa cells in vitro. Toxicol in vitro. 2011;25:657–663.
NAV and Front matter. J Navig. 1994; 47(3):f1–f2.
Welcome to SEER Training | SEER Training, https://training.seer.cancer.gov/. accessed 29 June 2020.
Ayhan E, Kesmezacar H, Akgun I. Intraarticular injections (corticosteroid, hyaluronic acid, platelet rich plasma) for the knee osteoarthritis. World J Orthop. 2014;5(3):351--61. The Journal of Sports Medicine and Physical Fitness Variables PRP group. 2014;24:59–13.
Parmegiani L, Cognigni GE, Ciampaglia W, et al., Efficiency of hyaluronic acid (HA) sperm selection. J Assist Reprod Genet. 2010;27:13–16.
Junca A, Gonzalez Marti B, Tosti E, et al., Sperm nucleus decondensation, hyaluronic acid (HA) binding and oocyte activation capacity: different markers of sperm immaturity? Case reports. J Assist Reprod Genet. 2012;29:353–355.
Miller J, Wynes J. Updates on Bioengineered Alternative Tissues. Clin Podiatr Med Surg. 2019;36:413–424.
Ke C, Sun L, Qiao D, et al. Antioxidant acitivity of low molecular weight hyaluronic acid. Food Chem Toxicol. 2011;49:2670–2675.
Goa KL, Benfield P. Hyaluronic Acid. Drugs. 1994;47:536–566.
Burdick JA, Prestwich GD. Hyaluronic acid hydrogels for biomedical applications. Adv Mater. 2011;23:41–56.
Zhou L, Chen E, Jin W, et al., Monomer zinc phthalocyanine/upconversion nanoparticle coated with hyaluronic acid crosslinked gel as NIR light-activated drug for in vitro photodynamic therapy. Dalton Trans. 2016;45:15170–15179.
Daou CAZ, Bassim M. Hyaluronic acid in otology: Its uses, advantages and drawbacks - A review. American Journal of Otolaryngology. 2020;41:102375.
Highley CB, Prestwich GD, Burdick JA. Recent advances in hyaluronic acid hydrogels for biomedical applications. Curr Opin Biotechnol. 2016;40:35–40.
Kroes B, van den Berg A, van Ufford HQ, et al., Anti-Inflammatory Activity of Gallic Acid. Planta Medica. 1992;58:499–504.
Wakefield D, Herbort CP, Tugal-Tutkun I, et al., Controversies in ocular inflammation and immunology laser flare photometry. Ocul Immunol Inflamm. 2010;18:334– 340.
Brainina KZ, Ivanova AV, Sharafutdinova EN, et al., Potentiometry as a method of antioxidant activity investigation. Talanta. 2007;71:13–18.
Yun YS, Nakajima Y, Iseda E, et al., Determination of Antioxidant Activity of Herbs by ESR. Journal of the Food Hygienic Society of Japan (Shokuhin Eiseigaku Zasshi). 2003;44:59–62.
-
Abstract View: 458 times
PDF Download: 269 times
