Self Assembling Peptide P11-4 for Enamel Remineralization: A Biomimetic Approach
Journal of Pharmaceutical Research International,
Page 83-89
DOI:
10.9734/jpri/2020/v32i1930712
Abstract
Treatment of caries through conventional modalities involves an invasive approach of excavation of the carious lesion followed by a restoration. This compromises on the strength and integrity of the tooth structure. Minimal invasive dentistry aims at early detection of the carious lesion and their remineralization. Self assembling peptides find its application in the medical field due to its ability to form a scaffold through a process of hierarchical organization into nano structures. Self-assembling peptide P11-4 is a novel technology for enamel remineralization through a biomimetic approach. The technology simulates normal enamel histogenesis. It induces de novo precipitation of hydroxyapatite crystals by forming a three dimensional scaffold matrix. The formation of the scaffold involves the conversion of the peptide from a low viscosity fluid to a nematic gel under low pH conditions. This scaffold matrix further attracts calcium ions and leads to formation of hydroxyapatite crystals. Being minimally invasive, it helps in preserving the strength and integrity of the tooth structure. The aim of the article is to review the technology of self assembling peptides for enamel regeneration and its potential as a material for successful treatment of early carious lesions through a minimally invasive approach.
Keywords:
- Biomimetics
- self-assembling peptide
- dental remineralization
- peptide P11-4
- early carious lesion
How to Cite
Gulzar, R. A., Ajitha, P., & Subbaiyan, H. (2020). Self Assembling Peptide P11-4 for Enamel Remineralization: A Biomimetic Approach. Journal of Pharmaceutical Research International, 32(19), 83-89. https://doi.org/10.9734/jpri/2020/v32i1930712
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Aggeli A, Bell M, Carrick LM, et al. pH as a Trigger of Peptide β-Sheet Self-Assembly and Reversible Switching between Nematic and Isotropic Phases. Journal of the American Chemical Society. 2003;125:9619–9628.
Fan T, Yu X, Shen B, et al. Peptide Self-Assembled Nanostructures for Drug Delivery Applications. Journal of Nanomaterials. 2017;2017:1–16.
Panda JJ, Chauhan VS. Short peptide based self-assembled nanostructures: implications in drug delivery and tissue engineering. Polym. Chem. 2014;5:4431–4449.
Gelain F, Horii A, Zhang S. Designer Self-Assembling Peptide Scaffolds for 3-D Tissue Cell Cultures and Regenerative Medicine. Macromolecular Bioscience. 2007;7:544–551.
Toksoz S, Acar H, Guler MO. Self-assembled one-dimensional soft nanostructures. Soft Matter. 2010;6:5839.
Aggeli A, Bell M, Boden N, et al. Self-Assembling Peptide Polyelectrolyteβ-Sheet Complexes Form Nematic Hydrogels. Angewandte Chemie. 2003;115:5761–5764.
Kirkham J, Firth A, Vernals D, et al. Self-assembling peptide scaffolds promote enamel remineralization. J Dent Res. 2007;86:426–430.
Brunton PA, Davies RPW, Burke JL, et al. Treatment of early caries lesions using biomimetic self-assembling peptides – a clinical safety trial. British Dental Journal. 2013;215:E6–E6.
Davies RPW, Aggeli A, Beevers AJ, et al. Self-assembling β-Sheet Tape Forming Peptides. Supramolecular Chemistry. 2006;18:435–443.
Wierichs RJ, Kogel J, Lausch J, et al. Effects of Self-Assembling Peptide P11-4, Fluorides, and Caries Infiltration on Artificial Enamel Caries Lesions in vitro. Caries Res. 2017;51:451–459.
Jablonski-Momeni A, Heinzel-Gutenbrunner M. Efficacy of the self-assembling peptide P11-4 in constructing a remineralization scaffold on artificially-induced enamel lesions on smooth surfaces. J Orofac Orthop. 2014;75:175–190.
Schlee M, Schad T, Koch JH, et al. Clinical performance of self‐assembling peptide P 11 ‐4 in the treatment of initial proximal carious lesions: A practice‐based case series. Journal of Investigative and Clinical Dentistry; 9. Epub ahead of print 2018.
DOI: 10.1111/jicd.12286.
Geddes DA. Acids produced by human dental plaque metabolism in situ. Caries Res. 1975;9:98–109.
Ceci M, Mirando M, Beltrami R, et al. Effect of self-assembling peptide P11 -4 on enamel erosion: AFM and SEM studies. Scanning. 2016;38:344–351.
Suda S, Takamizawa T, Takahashi F, et al. Application of the Self- Assembling Peptide P11-4 for Prevention of Acidic Erosion. Operative Dentistry. 2018;43:E166–E172.
Schlee M, Rathe F, Bommer C, et al. Self-assembling peptide matrix for treatment of dentin hypersensitivity: A randomized controlled clinical trial. Journal of Periodontology. 2018;89:653–660.
Reeh ES, Messer HH, Douglas WH. Reduction in tooth stiffness as a result of endodontic and restorative procedures. J Endod 1989;15:512–516.
Alkilzy M, Santamaria RM, Schmoeckel J, et al. Treatment of Carious Lesions Using Self-Assembling Peptides. Advances in Dental Research. 2018;29:42–47.
Buzalaf MAR, Pessan JP. New Preventive Approaches Part I: Functional Peptides and Other Therapies to Prevent Tooth Demineralization. Root Caries: From Prevalence to Therapy. 2017;88–96.
Robinson C, Shore RC, Brookes SJ, et al. The Chemistry of Enamel Caries. Critical Reviews in Oral Biology & Medicine. 2000;11:481–495.
Cheng ZJ, Wang XM, Cui FZ, et al. The enamel softening and loss during early erosion studied by AFM, SEM and nanoindentation. Biomedical Materials. 2009;4:015020.
Boland TW. Dental erosion: more acid means fewer teeth. New South Wales Public Health Bulletin. 1999;10:35.
Mizrahi E. Enamel demineralization following orthodontic treatment. Am J Orthod. 1982;82:62–67.
Gurunathan D, Somasundaram S, Kumar SA. Casein phosphopeptide-amorphous calcium phosphate: a remineralizing agent of enamel. Australian Dental Journal. 2012;57:404–408.
Li X, Wang J, Joiner A, et al. The remineralisation of enamel: a review of the literature. Journal of Dentistry. 2014;42:12–S20.
Caruso S, Bernardi S, Pasini M, et al. The process of mineralisation in the development of human tooth. Eur J Paediatr Dent. 2016;17:322–326.
Jenarthanan S, Subbarao C. Comparative evaluation of the efficacy of diclofenac sodium administered using different delivery routes in the management of endodontic pain: A randomized controlled clinical trial. Journal of Conservative Dentistry. 2018;21:297.
Khandelwal A, Palanivelu A. Correlation between Dental Caries And Salivary Albumin In Adult Population In Chennai: An In Vivo Study. Brazilian Dental Science 2019;22:228–233.
Malli Sureshbabu N, Selvarasu K, VJK, et al. Concentrated Growth Factors as an Ingenious Biomaterial in Regeneration of Bony Defects after Periapical Surgery: A Report of Two Cases. Case Rep Dent. 2019;7046203.
Nandakumar M, Nasim I. Comparative evaluation of grape seed and cranberry extracts in preventing enamel erosion: An optical emission spectrometric analysis. J Conserv Dent. 2018;21:516–520.
Siddique R, Nivedhitha MS, Jacob B. Quantitative analysis for detection of toxic elements in various irrigants, their combination (precipitate), and para-chloroaniline: An inductively coupled plasma mass spectrometry study. J Conserv Dent. 2019;22:344–350.
Teja KV, Ramesh S, Priya V. Regulation of matrix metalloproteinase-3 gene expression in inflammation: A molecular study. J Conserv Dent. 2018;21:592–596.
Siddique R, Sureshbabu NM, Somasundaram J, et al. Qualitative and quantitative analysis of precipitate formation following interaction of chlorhexidine with sodium hypochlorite, neem, and tulsi. J Conserv Dent. 2019;22:40–47.
Rajendran R, Kunjusankaran RN, Sandhya R, et al. Comparative Evaluation of Remineralizing Potential of a Paste Containing Bioactive Glass and a Topical Cream Containing Casein Phosphopeptide-Amorphous Calcium Phosphate: An in Vitro Study. Pesquisa Brasileira em Odontopediatria e Clínica Integrada. 2019;19:1–10.
Govindaraju L, Neelakantan P, Gutmann JL. Effect of root canal irrigating solutions on the compressive strength of tricalcium silicate cements. Clin Oral Investig. 2017;21:567–571.
Manohar MP, Sharma S. A survey of the knowledge, attitude, and awareness about the principal choice of intracanal medicaments among the general dental practitioners and nonendodontic specialists. Indian J Dent Res. 2018;29:716–720.
Janani K, Sandhya R. A survey on skills for cone beam computed tomography interpretation among endodontists for endodontic treatment procedure. Indian J Dent Res. 2019;30:834–838.
Poorni S, Srinivasan MR, Nivedhitha MS. Probiotic strains in caries prevention: A systematic review. J Conserv Dent. 2019;22:123–128.
Azeem RA, Sureshbabu NM. Clinical performance of direct versus indirect composite restorations in posterior teeth: A systematic review. J Conserv Dent. 2018;21:2–9.
R R, Rajakeerthi R, Ms N. Natural Product as the Storage medium for an avulsed tooth – A Systematic Review. Cumhuriyet Dental Journal. 2019;22:249–256.
Siddique R, Nivedhitha MS. Effectiveness of rotary and reciprocating systems on microbial reduction: A systematic review. J Conserv Dent. 2019;22:114–122.
Ramarao S, Sathyanarayanan U. CRA Grid - A preliminary development and calibration of a paper-based objectivization of caries risk assessment in undergraduate dental education. J Conserv Dent. 2019;22:185–190.
Acar H, Srivastava S, Chung EJ, et al. Self-assembling peptide-based building blocks in medical applications. Advanced Drug Delivery Reviews. 2017;110-111:65–79.
Aggeli A, Bell M, Carrick LM, et al. pH as a Trigger of Peptide β-Sheet Self-Assembly and Reversible Switching between Nematic and Isotropic Phases. Journal of the American Chemical Society. 2003;125:9619–9628.
Fan T, Yu X, Shen B, et al. Peptide Self-Assembled Nanostructures for Drug Delivery Applications. Journal of Nanomaterials. 2017;2017:1–16.
Panda JJ, Chauhan VS. Short peptide based self-assembled nanostructures: implications in drug delivery and tissue engineering. Polym. Chem. 2014;5:4431–4449.
Gelain F, Horii A, Zhang S. Designer Self-Assembling Peptide Scaffolds for 3-D Tissue Cell Cultures and Regenerative Medicine. Macromolecular Bioscience. 2007;7:544–551.
Toksoz S, Acar H, Guler MO. Self-assembled one-dimensional soft nanostructures. Soft Matter. 2010;6:5839.
Aggeli A, Bell M, Boden N, et al. Self-Assembling Peptide Polyelectrolyteβ-Sheet Complexes Form Nematic Hydrogels. Angewandte Chemie. 2003;115:5761–5764.
Kirkham J, Firth A, Vernals D, et al. Self-assembling peptide scaffolds promote enamel remineralization. J Dent Res. 2007;86:426–430.
Brunton PA, Davies RPW, Burke JL, et al. Treatment of early caries lesions using biomimetic self-assembling peptides – a clinical safety trial. British Dental Journal. 2013;215:E6–E6.
Davies RPW, Aggeli A, Beevers AJ, et al. Self-assembling β-Sheet Tape Forming Peptides. Supramolecular Chemistry. 2006;18:435–443.
Wierichs RJ, Kogel J, Lausch J, et al. Effects of Self-Assembling Peptide P11-4, Fluorides, and Caries Infiltration on Artificial Enamel Caries Lesions in vitro. Caries Res. 2017;51:451–459.
Jablonski-Momeni A, Heinzel-Gutenbrunner M. Efficacy of the self-assembling peptide P11-4 in constructing a remineralization scaffold on artificially-induced enamel lesions on smooth surfaces. J Orofac Orthop. 2014;75:175–190.
Schlee M, Schad T, Koch JH, et al. Clinical performance of self‐assembling peptide P 11 ‐4 in the treatment of initial proximal carious lesions: A practice‐based case series. Journal of Investigative and Clinical Dentistry; 9. Epub ahead of print 2018.
DOI: 10.1111/jicd.12286.
Geddes DA. Acids produced by human dental plaque metabolism in situ. Caries Res. 1975;9:98–109.
Ceci M, Mirando M, Beltrami R, et al. Effect of self-assembling peptide P11 -4 on enamel erosion: AFM and SEM studies. Scanning. 2016;38:344–351.
Suda S, Takamizawa T, Takahashi F, et al. Application of the Self- Assembling Peptide P11-4 for Prevention of Acidic Erosion. Operative Dentistry. 2018;43:E166–E172.
Schlee M, Rathe F, Bommer C, et al. Self-assembling peptide matrix for treatment of dentin hypersensitivity: A randomized controlled clinical trial. Journal of Periodontology. 2018;89:653–660.
Reeh ES, Messer HH, Douglas WH. Reduction in tooth stiffness as a result of endodontic and restorative procedures. J Endod 1989;15:512–516.
Alkilzy M, Santamaria RM, Schmoeckel J, et al. Treatment of Carious Lesions Using Self-Assembling Peptides. Advances in Dental Research. 2018;29:42–47.
Buzalaf MAR, Pessan JP. New Preventive Approaches Part I: Functional Peptides and Other Therapies to Prevent Tooth Demineralization. Root Caries: From Prevalence to Therapy. 2017;88–96.
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