Effect of Oxygen Releasing Oral Gel Compared to Chlorhexidine Gel in the Treatment of Periodontitis
Journal of Pharmaceutical Research International,
The aim of the current study is to compare the effect of oxygen releasing oral gel and chlorhexidine gel in the treatment of periodontitis and the objective was to assess and compare the changes in clinical parameters such as Probing pocket depth, Bleeding on probing, Clinical attachment levels between oxygen releasing oral gel and chlorhexidine gel.
The current pilot study which compares oxygen releasing gel with chlorhexidine gel is a randomised split mouth clinical trial .All the patients included in the study were patients with moderate to severe periodontitis with no systemic diseases, not under any medication non smoking healthy patients. All the patients received supra and sub gingival scaling, pockets on molars with deeper probing depth on either maxillary or mandibular arch and the medication to be received by the patient were allotted randomly. Randomisation was performed using lot method.Oxygen releasing (Blue M gel) and chlorhexidine gel (Hexigel) was applied at the chosen site, patient was recalled for re application and was reassessed for clinical parameters Paired t test was done to compare the mean difference in probing depth in Blue M gel group and Hexigel group.
The mean probing depth at the day of drug delivery was for Blue M gel group was 7.2 mm SD+/-0.42 mm and the mean probing depth six week after drug delivery was 4.7 SD+/- 0.57 mm with a significant p value of 0.42. The mean probing depth at the day of drug delivery was for Hexigel gel group was 7.0 mm SD+/-0.57 mm and the mean probing depth six week after drug delivery was 5.7 SD+/- 0.64 mm.
Within the limitations of the study from the results it is seen that there is a significant difference in reduction in probing pocket depth. The mean difference between the probing depth reduction in group A (Blue M ) from baseline to 6 week was 2.3 and The mean difference probing depth reduction in group B (Hexigel ) from baseline to 6 week was 1.5. Group A showed better potential in probing depth reduction. It emphasises the fact that thorough sub gingival scaling and root planing along with adjuvant topical oxygen therapy aid in reducing the periodontal pockets further research has to be done to assess the effect of oxygen delivering agents in future.
- oxygen therapy
- topical oxygen
How to Cite
Wang XX, Chen Y, Leung WK. Role of the Hypoxia-Inducible Factor in Periodontal Inflammation. Hypoxia and Human Diseases. 2017;285.
Piruat JI, López-Barneo J. Oxygen tension regulates mitochondrial DNA-encoded complex I gene expression. Journal of Biological Chemistry. 2005;280:42676–42684.
Semba H, Takeda N, Isagawa T, et al. HIF-1α-PDK1 axis-induced active glycolysis plays an essential role in macrophage migratory capacity. Nat Commun. 2016;7:11635.
Wu D, Chen B, Cui F, et al. Hypoxia-induced microRNA-301b regulates apoptosis by targeting Bim in lung cancer. Cell Proliferation. 2016;49:476–483.
Li X, Liu Y, Ma H, et al. Enhancement of glucose metabolism via PGC-1α participates in the cardioprotection of chronic intermittent hypobaric hypoxia. Frontiers in Physiology. 2016;7:Epub ahead of Print.
Katayama K, Ishida K, Saito M, et al. Hypoxia attenuates cardiopulmonary reflex control of sympathetic nerve activity during mild dynamic leg exercise. Experimental Physiology. 2016;101:377–386.
Hyun S-W, Jung Y-S. Hypoxia induces FoxO3a-mediated dysfunction of blood–brain barrier. Biochemical and Biophysical Research Communications. 2014;450: 1638–1642.
Semenza GL. Oxygen sensing, hypoxia-inducible factors, and disease pathophysiology. Annu Rev Pathol. 2014; 9:47–71.
Gölz L, Memmert S, Rath-Deschner B, et al. LPS from P. gingivalis and hypoxia increases oxidative stress in periodontal ligament fibroblasts and contributes to periodontitis. Mediators of Inflammation. 2014;2014:1–13.
Knighton D, Hunt T, Scheuenstuhl H, et al. Oxygen tension regulates the expression of angiogenesis factor by macrophages. Science. 1983;221:1283–1285.
Rodriguez PG, Felix FN, Woodley DT, et al. The role of oxygen in wound healing: A review of the literature. Dermatologic Surgery. 2008;34:1159–1169.
Conconi MT, Baiguera S, Guidolin D, et al. effects of hyperbaric oxygen on proliferative and apoptotic activities and reactive oxygen species generation in mouse fibroblast 3T3/J2 cell line. Journal of Investigative Medicine. 2003;51:227–232.
Kalliainen LK, Gordillo GM, Schlanger R, et al. Topical oxygen as an adjunct to wound healing: A clinical case series. Pathophysiology. 2003;9:81–87.
Ezhilarasan D, Apoorva VS, Ashok Vardhan N. Syzygium cumini extract induced reactive oxygen species-mediated apoptosis in human oral squamous carcinoma cells. J Oral Pathol Med. 2019; 48:115–121.
Kaarthikeyan G, Jayakumar ND, Sivakumar D. Comparative evaluation of bone formation between PRF and blood clot alone as the sole sinus-filling material in maxillary sinus augmentation with the implant as a tent pole: A randomized split-mouth study. J Long Term Eff Med Implants. 2019;29:105–111.
Arjunkumar R. Nanomaterials for the management of periodontal diseases. In: Chaughule RS, (Ed.). Dental Applications of Nanotechnology. Cham: Springer International Publishing. 2018;203–215.
Ravi S, Malaiappan S, Varghese S, et al. Additive effect of plasma rich in growth factors with guided tissue regeneration in treatment of intrabony defects in patients with chronic periodontitis: A split-mouth randomized controlled clinical trial. J Periodontol. 2017; 88:839–845.
Kavarthapu A, Malaiappan S. Comparative evaluation of demineralized bone matrix and type II collagen membrane versus eggshell powder as a graft material and membrane in rat model. Indian J Dent Res. 2019;30:877–880.
Murthykumar K, Arjunkumar R, Jayaseelan VP. Association of vitamin D receptor gene polymorphism (rs10735810) and chronic periodontitis. J Investig Clin Dent. 2019; 10:e12440.
Ramesh A, Vellayappan R, Ravi S, et al. Esthetic lip repositioning: A cosmetic approach for correction of gummy smile - A case series. J Indian Soc Periodontol. 2019;23:290–294.
Ramesh A, Varghese S, Jayakumar ND, et al. Comparative estimation of sulfiredoxin levels between chronic periodontitis and healthy patients - A case-control study. J Periodontol. 2018;89:1241–1248.
Kavarthapu A, Thamaraiselvan M. Assessing the variation in course and position of inferior alveolar nerve among south Indian population: A cone beam computed tomographic study. Indian J Dent Res. 2018;29:405–409.
Ramesh A, Ravi S, Kaarthikeyan G. Comprehensive rehabilitation using dental implants in generalized aggressive periodontitis. J Indian Soc Periodontol. 2017;21:160–163.
Jain M, Nazar N. comparative evaluation of the efficacy of intraligamentary and supraperiosteal injections in the extraction of maxillary teeth: A randomized controlled clinical trial. J Contemp Dent Pract. 2018; 19:1117–1121.
Vijayashree Priyadharsini J. In silico validation of the non-antibiotic drugs acetaminophen and ibuprofen as antibacterial agents against red complex pathogens. J Periodontol. 2019;90:1441–1448.
Ramamurthy J, Mg V. Comparison of effect of hiora mouthwash versus chlorhexidine mouthwash in gingivitis patients: A clinical Trial. Asian J Pharm Clin Res. 2018;11:84–88.
Fries RB, Wallace WA, Roy S, et al. Dermal excisional wound healing in pigs following treatment with topically applied pure oxygen. Mutation Research/ Fundamental and Molecular Mechanisms of Mutagenesis. 2005;579:172–181.
Gaggl AJ, Rainer H, Grund E, et al. Local oxygen therapy for treating acute necrotizing periodontal disease in smokers. J Periodontol. 2006;77:31–38.
Bakaeen GS, Strahan JD. Effects of a 1% chlorhexidine gel during the healing phase after inverse bevel mucogingival flap surgery. Journal of Clinical Periodontology. 1980;7:20–25.
Fiorillo L. Chlorhexidine gel use in the oral district: A systematic review. Gels; 5. 2019; Epub ahead of print.
Deliberador TM, Weiss SG, Rychuv F, et al. Comparative analysis in vitro of the application of blue®m oral gel versus chlorhexidine on Porphyromonas gingivalis: A pilot study. Advances in Microbiology. 2020;10:194–201.
Abstract View: 618 times
PDF Download: 317 times