Antimicrobial Susceptibility Pattern of Klebsiella Species from Various Clinical Samples at a Tertiary Care Hospital

Main Article Content

K. Sathyavathy
B. Kiran Madhusudhan

Abstract

The aim of the study was to investigate the antimicrobial susceptibility pattern of Klebsiella species from different clinical samples at Sree Balaji Medical College and Hospital, India. Overall 189 samples out of 980 non repetitive clinical samples obtained from wound/pus, urine, sputum swab and blood by disc diffusion method and identified as Klebsiella and analysed. Out of total 189 Klebsiella isolates, 76 out of 155 K. pneumoniae (49%) were resistant and none out of 34 Klebsiella oxytoca (0%) showed resistance to cefotaxime and ceftazidime by disc diffusion method. Antimicrobial susceptibility testing of Klebsiella exhibited 100% resistance to Ampicillin. The present study highlights the need for the continued monitoring of antimicrobial susceptibility patterns of important bacterial pathogens, so that rational antibiotic policies can be formulated.

Keywords:
Klebsiella pneumoniae, Klebsiella oxytoca, antimicrobial susceptibility, cefotaxime

Article Details

How to Cite
Sathyavathy, K., & Madhusudhan, B. K. (2020). Antimicrobial Susceptibility Pattern of Klebsiella Species from Various Clinical Samples at a Tertiary Care Hospital. Journal of Pharmaceutical Research International, 32(12), 143-147. https://doi.org/10.9734/jpri/2020/v32i1230571
Section
Original Research Article

References

Reacher MH, Shah A, Livermore DM, Wale MCJ, Graham C, Johnson AP, et al. Bacteraemia and antibiotic resistance of its pathogens reported in England and Wales between 1990 and 1998: Trend analysis. BMJ. 2000;320(7229):213.

Podschun R, Ullmann U. Klebsiella spp. as nosocomial pathogens: Epidemiology, taxonomy, typing methods, and pathogenicity factors. Clin Microbiol Rev. 1998;11(4):589–603.

C.S.J., et al. Protection against fatal Klebsiella pneumoniae burn wound sepsis by passive transfer of anticapsular polysaccharide. - PubMed - NCBI.

Thomson KS. Controversies about extended-spectrum and AmpC beta-lactamases. Emerg Infect Dis. 2001;7(2): 333–6.

Turner PJ. Extended-spectrum β-lactamases. Clin Infect Dis. 2005; 41(Supplement_4):S273–5.

Bush K, Jacoby GA. Updated functional classification of β-Lactamases. Antimicrob Agents Chemother. 2010;54(3):969.

Navidinia M. The clinical importance of emerging ESKAPE pathogens in nosocomial infections. ISSN. 7:15.

Bailey & Scott’s Diagnostic Microbiology (Diagnostic Microbiology (Bailey & Scott’s)): 9780323083300.

Biradar S, Roopa C. Isolation and Antibiogram of Klebsiella species from Various Clinical Specimens. 2015;5.

Namratha K, Sreeshma P, Subbannayya K, Dinesh P, Champa H. Characterization and Antibiogram of Klebsiella spp. Isolated from Clinical Specimen in a Rural Teaching Hospital; 2015.

Ali Abdel Rahim KA, Ali Mohamed AM. Prevalence of extended spectrum β-lactamase-producing Klebsiella pneumoniae in clinical isolates. Jundishapur J Microbiol. 2014;7(11): e17114.

Phamba SG, Saldanha DRM, Professor, Department of Microbiology, Yenepoya Medical College, Deralakatte, Mangalore- 575018, Karnataka, India. 2. Prevalence of Extended spectrum beta- lactamase (ESBL) producing Klebsiella species and Escherichia coli among clinical isolates in a tertiary care hospital. J Int Med Dent. 2017;4(1):06–12.

Santajit S, Indrawattana N. Mechanisms of antimicrobial resistance in ESKAPE pathogens. BioMed Research International; 2016.