Association of Lympho-vascular Invasion with Various Known Prognostic Markers in Breast Carcinomna

Main Article Content

Moumita Dam
Hemalatha Ganapathy

Abstract

Breast cancer is the one of the most frequent neoplasm in women. In the last decades, detection of disease in earlier clinical stages has improved prognosis, however five-year disease-free survival still remains at about 72%. For this reason, continuing efforts to establish reliable prognostic markers are made. The presence of lymph node metastasis is one of the most important prognostic factors in breast cancer.  Studies show that D2-40 immuno-stain demonstrated a significant higher detection of LVI as compared with routine H&E staining in early breast cancer. LVI is associated with axillary lymph node metastases and a long-term prognostic factor. A precise identification of LVI would have a strong clinical impact for breast cancer patients. In this study, we aim to demonstrated.

LVI as a significant predictor of poor prognosis in patients with lymph node- negative patients with primary invasive breast cancer and its association with other known parameters such as tumour size, tumour grade, nodal metastasis and age.

Keywords:
Breast neoplasms, Lymph node metastasis, Lympho-vascular invasion, prognostic factor.

Article Details

How to Cite
Dam, M., & Ganapathy, H. (2020). Association of Lympho-vascular Invasion with Various Known Prognostic Markers in Breast Carcinomna. Journal of Pharmaceutical Research International, 32(12), 132-142. https://doi.org/10.9734/jpri/2020/v32i1230570
Section
Original Research Article

References

DeSantis C, Bray F, Ferlay J, Lortet-Tieulent J, Anderson B, Jemal A. International variation in female breast cancer incidence and mortality rates. Cancer Epidemiol. Biomarkers Prev. 2015; 24(10):1495-06.

Lester S. The breast. In: Kumar V, Abbas A, Aster J, ed. By, Robbins & Cotran Pathologic Basis of Disease. 9th Ed. Philadelphia: Elesevier. 2015;1043-71.

Allred DC, Harvey JM, Berardo M, Clark GM. Prognostic and predictive factors in breast cancer by immunohistochemical analysis. Mod Pathol. 1998;11(2):155-68.

Da Costa Vieira RA, Biller G, Uemura G, Ruiz CA, Curado MP. Breast cancer screening in developing countries. Clinics (Sao Paulo). 2017;72(4):244-253.

Tavassoli FA, Devilee P, editors. Pathology and genetics of tumours of the breast and female genital organs. IARC; 2003.

Weidner N, Semple JP, Welch WR, et al. Tumour angiogenesis and metastasis- Correlation in invasive breast carcinoma. N Engl J Med. 1991;324(1):1-8.

Weidner N. Intratumor MV density as a prognostic factor in cancer. Am J Pathol. 1995;147(1):9-19.

Yamauchi C, Hasebe T, Iwasaki M, Imoto S, Wada N, Fukayama M, Ochiai A. Accurate assessment of lymph vessel tumor emboli in invasive ductal carcinoma of the breast according to tumor areas, and their prognostic significance. Human Pathology. 2007;38(2):247-59.

Lakhtakia R. A brief history of breast cancer: Part I: Surgical domination reinvented. Sultan Qaboos University Medical Journal. 2014;14(2):e166.

Forman D, Ferlay J, Stewart BW, Wild CP. The global and regional burden of cancer. World Cancer Report. 2014;5:16-54.

Weigelt B, Peterse JL, Van't Veer LJ. Breast cancer metastasis: Markers and models. Nature Reviews Cancer. 2005; 5(8):591.

Cunnick GH, Jiang WG, Douglas-Jones T, Watkins G, Gomez KF, Morgan MJ, Subramanian A, Mokbel K, Mansel RE. Lymphangiogenesis and lymph node metastasis in breast cancer. Molecular Cancer. 2008;7(1):23.

Gill PG, Luke CG, Roder DM. Clinical and pathological factors predictive of lymph node status in women with screen-detected breast cancer. The Breast. 2006; 15(5):640-8.

Aitken E, Osman M. Factors affecting nodal status in invasive breast cancer: A retrospective analysis of 623 patients. The Breast Journal. 2010;16(3):271-8.

Song YJ, Shin SH, Cho JS, Park MH, Yoon JH, Jegal YJ. The role of lymphovascular invasion as a prognostic factor in patients with lymph node-positive operable invasive breast cancer. Journal of Breast Cancer. 201;14(3):198-203.

Rivadeneira DE, Simmons RM, Christos PJ, Hanna K, Daly JM, Osborne MP. Predictive factors associated with axillary lymph node metastases in T1a and T1b breast carcinomas: Analysis in more than 900 patients22. Journal of the American College of Surgeons. 2000;191(1):1-6.

Liu YL, Saraf A, Lee SM, Zhong X, Hibshoosh H, Kalinsky K, Connolly EP. Lymphovascular invasion is an independent predictor of survival in breast cancer after neoadjuvant chemotherapy. Breast Cancer Research and Treatment. 2016;157(3):555-64.

Lee JA, Bae JW, Woo SU, Kim H, Kim CH. D2-40, podoplanin, and CD31 as a prognostic predictor in invasive ductal carcinomas of the breast. Journal of Breast Cancer. 2011;14(2):104-11.

Krishnamurthy J, Kumar PS. Significance of prognostic indicators in infiltrating duct carcinoma breast: Scenario in developing country. Indian Journal of Cancer. 2016; 53(1):34.

Tezuka K, Onoda N, Takashima T, Takagaki K, Ishikawa T, Wakasa T, Wakasa K, Hirakawa K. Prognostic significance of lymphovascular invasion diagnosed by lymphatic endothelium immunostaining in breast cancer patients. Oncology Reports. 2007;17(5):997-1003.

Gujam FJ, McMillan DC, Mohammed ZM, Edwards J, Going JJ. The relationship between tumour budding, the tumour microenvironment and survival in patients with invasive ductal breast cancer. British Journal of Cancer. 2015;113(7):1066.

Rakha EA, Martin S, Lee AH, Morgan D, Pharoah PD, Hodi Z, MacMillan D, Ellis IO. The prognostic significance of lymphovascular invasion in invasive breast carcinoma. Cancer. 2012;118(15):3670-80.

Agarwal S, Singh A, Bagga PK. Immunohistochemical evaluation of lymphovascular invasion in carcinoma breast with CD34 and D2-40 and its correlation with other prognostic markers. Indian Journal of Pathology and Microbiology. 2018;61(1):39.

Nakamura Y, Yasuoka H, Tsujimoto M, Imabun S, Nakahara M, Nakao K, Nakamura M, Mori I, Kakudo K. Lymph vessel density correlates with nodal status, VEGF-C expression, and prognosis in breast cancer. Breast Cancer Research and Treatment. 2005;91(2):125-32.

Ansari MA, Pandey V, Srivastava V, Kumar M, Mishra RN, Kumar A. Lymphangiogenesis as a prognostic marker in breast cancer using D2-40 as lymphatic endothelial marker—a preliminary study. Journal of Cancer Therapy. 2012;3(05):814.

Ejlertsen B, Jensen MB, Rank F, Rasmussen BB, Christiansen P, Kroman N, Kvistgaard ME, Overgaard M, Toftdahl DB, Mouridsen HT, Danish Breast Cancer Cooperative Group. Population-based study of peritumoral lymphovascular invasion and outcome among patients with operable breast cancer. JNCI: Journal of the National Cancer Institute. 2009; 101(10):729-35.

Wang J, Guo Y, Wang B, Bi J, Li K, Liang X, Chu H, Jiang H. Lymphatic microvessel density and vascular endothelial growth factor-C and-D as prognostic factors in breast cancer: A systematic review and meta-analysis of the literature. Molecular Biology Reports. 2012;39(12): 11153-65.

Ordóñez NG. Value of podoplanin as an immunohistochemical marker in tumor diagnosis: A review and update. Applied Immunohistochemistry & Molecular Morphology. 2014;22(5):331-47.

Ito M, Moriya T, Ishida T, Usami S, Kasajima A, Sasano H, Ohuchi N. Significance of pathological evaluation for lymphatic vessel invasion in invasive breast cancer. Breast Cancer. 2007;14(4): 381-7.

Agarwal D, Pardhe N, Bajpai M, et al. Characterization, localization and patterning of lymphatics and blood vessels in oral squamous cell carcinoma: A comparative study using D2‐40 and CD‐34 IHC marker. J Clin Diagn Res. 2014;8(10): ZC86‐ZC89.