Identification of Metronidazole – Drug Interactions at the Outpatient Setting in Alkharj

Main Article Content

Nehad J. Ahmad

Abstract

Introduction: Metronidazole  is an antibacterial, antiprotozoal and amebicidal agent. It has a good activity against pathogenic anaerobic bacteria, low cost, minor adverse effects and a favorable pharmacodynamic and pharmacokinetic properties but still it interacts with many drugs.

Objective: This study aims to assess the interactions of metronidazole with other drugs at the outpatient setting in Alkharj.

Methodology: This is a retrospective study include revision of the electronic records in the outpatient setting in a public hospital in Alkharj in order to determine the incidence of interactions between metronidazole and other drugs in 2017.

Results: In the present study, the concurrent use of metronidazole with azithromycin, ciprofloxacin, domperidone, formoterol and olanzapine may result in increased risk of QT-interval prolongation and arrhythmias. The use of metronidazole with warfarin may result in increased risk of bleeding.

Conclusion: To dispense and prescribe it appropriately antimicrobial stewardship program should be implemented and checking practice should be implemented to avoid the occurrence of Drug - drug interactions.

Keywords:
Adverse reaction, antibiotics, drug interactions, metronidazole

Article Details

How to Cite
Ahmad, N. J. (2020). Identification of Metronidazole – Drug Interactions at the Outpatient Setting in Alkharj. Journal of Pharmaceutical Research International, 32(12), 76-80. https://doi.org/10.9734/jpri/2020/v32i1230563
Section
Original Research Article

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