Serum Hepcidin as an Inflammatory Marker in Chronic Kidney Disease

Main Article Content

Jyothi Elizabeth Roy
B. Shanthi
V. S. Kalai Selvi

Abstract

Background: Hepcidin is known to be the central regulator of iron homeostasis in the body. It is up-regulated by inflammation and downregulated by anemia. CKD is a state of chronic inflammation seen in kidney. Previous work has shown that serum hepcidin levels were increased in patients with CKD. This was surprising as these patients had a chronic inflammatory state and co-existent anemia.

Aim and Objectives: The aim of the study is to estimate the levels of hepcidin in CKD patients and to check the correlation of hepcidin to inflammation in chronic kidney disease.

Methods: This cross-sectional study was conducted at the Department of Biochemistry, Central Laboratory, Sree Balaji Medical College and Hospital, Chromepet, Chennai during January 2017 - June 2018 among 50 patients of chronic kidney disease in the age group of 18-60 years. The blood samples were collected using vacutainer system. Samples for serum hepcidin, ferritin and hsCRP were collected in red topped plain vacuum tube. The samples were centrifuged at 3000 rpm for 15 minutes. The samples were then processed, and values were obtained. The data were analysed using SPSS package.

Results: The mean values of s. Hepcidin, s. ferritin and hsCRP levels were found to be increased in the study population. The mean value of s. hepcidin was found to have strong positive correlation with the mean values of s. ferritin and hsCRP with r-value > 0.7.

Conclusion: Hepcidin levels are elevated in CKD and hepcidin is a predictor of inflammation since it correlated well with the inflammatory markers hsCRP and ferritin levels.

Keywords:
Chronic Kidney Disease (CKD), hepcidin

Article Details

How to Cite
Roy, J. E., Shanthi, B., & Selvi, V. S. K. (2020). Serum Hepcidin as an Inflammatory Marker in Chronic Kidney Disease. Journal of Pharmaceutical Research International, 32(12), 40-45. https://doi.org/10.9734/jpri/2020/v32i1230558
Section
Original Research Article

References

Swinkels DW, Wetzels JF. Hepcidin: A new tool in the management of anaemia in patients with chronic kidney disease? Nephrol. Dial. Transplant. 2008;23(8): 2450-2453.

McCranor BJ, Langdon JM, Prince OD. Investigation of the role of interleukin-6 and hepcidin antimicrobial peptide in the development of anemia with age. Haematologica. 2013;98(10):1633- 1640.

Tarek Mohamed Ali, Ashraf Mahmoud Genina, Osama M. Abo-Salem. Corrigendum to “the determinants of hepcidin level in chronic kidney disease and hemodialysis Saudi patients”. Beni-Suef University Journal of Basic and Applied Sciences. 2014;3(3):238.

Malyszko J, Tesar V, Macdougall IC. Neutrophil gelatin associated lipocalin and hepcidin: What do they have in common and is there a potential interaction? Kidney Blood Press Res. 2010;33:157–165.

Lucile Mercadel, Marie Metzger, Jean-Philippe Haymann, Eric Thervet, Jean-Jacques Boa, et al. The relation of hepcidin to iron disorders, inflammation and hemoglobin in chronic kidney disease. PLoS ONE, Public Library of Science. 2014;9(6):e99781.

DOI: 10.1371/journal.pone.0099781. hal-01367481

Bertelsen M, Anggard EE, Carrier MJ. Oxidative stress impairs insulin internalization in endothelial cells in vitro. Diabetologia. 2001;44:605-13.

Peters HPE, Laarakkers CMM, Swinkels DW, Wetzels JFM. Serum hepcidin-25 levels in patients with chronic kidney disease are independent of glomerular filtration rate. Nephrol Dial Transpl Transpl. 2009;25:848e53.

Dallalio G, Fleury T, Means RT. Serum hepcidin in clinical specimens. Br J Haematol. 2003;122(6):996e1000.

Carmen Caldararu, Grigore Dogaru, Dorin Ionut Tarta, Adina Hutanu, Maria T Dogaru, Emilian Carasca, Mirela Liana Gliga. Oral iron for anaemia in non-dialysis chronic kidney disease. The relationship between hepcidin-25, iron metabolism and inflammation. Research Article - Biomedical Research. 2017; 28(8).

Kalidindi Raja Karthik, Chandru T, Ram Prasad E Varun Kumar B, Soudararajan P, Ramachandra S. Correlation of serum hepcidin levels with inflammation and iron status in patients with Esrd. Paripex - Indian Journal of Research. 2016;5(8): 8–10.