Hydnora africana Derived Phytochemicals against Acetaldehyde Dehydrogenase of Aeromonas hydrophila Causing Septicemia

Debajani Tripathy; Chandana Adhikari; Mukundjee Pandey; Bhagyeswari Behera; Srimay Pradhan; Akshay Kumar Sahu

doi:10.9734/jpri/2020/v32i930539

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Hydnora africana Derived Phytochemicals against Acetaldehyde Dehydrogenase of Aeromonas hydrophila Causing Septicemia

Debajani Tripathy

Chandana Adhikari

Mukundjee Pandey

Bhagyeswari Behera

Srimay Pradhan

Akshay Kumar Sahu

Journal of Pharmaceutical Research International, Page 114-117
DOI: 10.9734/jpri/2020/v32i930539
Published: 21 June 2020

Abstract

For drug discovery it takes approximately 6 years to expose in the market and for commercial uses. There are different procedure to get success in the drug discovery like preliminary phytochemical analysis, structural elucidation of the bioactive compound, preclinical test and clinical test etc. So to optimize the time for invention of new drug molecule, computer aided drug designing and molecular docking analysis is being used as one of the highly effective methodology. The phytochemical extraction of Hydnora africana plant was reported to inhibit the growth of Aeromonas hydrophila which cause Septicemia. “Biovia Discovery Studio” molecular docking methods give us opportunity to identify the effective molecule against the microbes. “High positive values of -CDOCKER energy and -CDOCKER interaction energy” recommended that flavone can effectively deactivate the acetaldehyde dehydrogenase enzyme thereby interrupting the life cycle of the organism.

Keywords:

Flavon
Hydnora africana
Aeromonas hydrophila
Septicemia

How to Cite

Tripathy, D., Adhikari, C., Pandey, M., Behera, B., Pradhan, S., & Sahu, A. K. (2020). Hydnora africana Derived Phytochemicals against Acetaldehyde Dehydrogenase of Aeromonas hydrophila Causing Septicemia. Journal of Pharmaceutical Research International, 32(9), 114-117. https://doi.org/10.9734/jpri/2020/v32i930539

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