Hydnora africana Derived Phytochemicals against Acetaldehyde Dehydrogenase of Aeromonas hydrophila Causing Septicemia

Main Article Content

Debajani Tripathy
Chandana Adhikari
Mukundjee Pandey
Bhagyeswari Behera
Srimay Pradhan
Akshay Kumar Sahu

Abstract

For drug discovery it takes approximately 6 years to expose in the market and for commercial uses. There are different procedure to get success in the drug discovery like preliminary phytochemical analysis, structural elucidation of the bioactive compound, preclinical test and clinical test etc. So to optimize the time for invention of new drug molecule, computer aided drug designing and molecular docking analysis is being used as one of the highly effective methodology. The phytochemical extraction of Hydnora africana plant was reported to inhibit the growth of Aeromonas hydrophila which cause Septicemia. “Biovia Discovery Studio” molecular docking methods give us opportunity to identify the effective molecule against the microbes. “High positive values of -CDOCKER energy and -CDOCKER interaction energy” recommended that flavone can effectively deactivate the acetaldehyde dehydrogenase enzyme thereby interrupting the life cycle of the organism.

Keywords:
Flavon, Hydnora africana, Aeromonas hydrophila, Septicemia

Article Details

How to Cite
Tripathy, D., Adhikari, C., Pandey, M., Behera, B., Pradhan, S., & Sahu, A. K. (2020). Hydnora africana Derived Phytochemicals against Acetaldehyde Dehydrogenase of Aeromonas hydrophila Causing Septicemia. Journal of Pharmaceutical Research International, 32(9), 114-117. https://doi.org/10.9734/jpri/2020/v32i930539
Section
Original Research Article

References

Henrich J, Heine S, Norenzayan A. The weirdest people in the world? Behavioral and Brain Sciences. 2010;33(2-3): 61-83.

DOI: 10.1017/S0140525X0999152X

Hussain I, Ullah R, Ullah R, Khurram M, Ullah N, Basee A, Khan F, Khattak M, Zahoor M, Khan J, Khan N. Phytochemical analysis of selected medicinal plant. African Journal of Biotechnology. 2011;10: 7487-7492.

Arulselvan P, Karthivashan G, Fakurazi S. Journal of Chemical and Pharmaceutical Research. 2013;5(7): 233-239.

Jay F. Bolin, Erika Maass, Lytton J. Musselman. Pollination biology of Hydnora africana Thunb. (Hydnoraceae) in Namibia: Brood‐site mimicry with insect imprisonment. International Journal of Plant Science. 2009;170(2).

Das D, Das S, Pandey M, Bhattacharyay D. In silico analysis of phytochemicals from Mucuna pruriens (L.) DC against Mycobacterium tuberculosis causing tuberculosis. European Journal of Medicinal Plants; 2020.

Leistner OA. Seed plants of southern tropical Africa: Families and genera. Southern African Botanical Diversity Network Report No. 26. Sabonet, Pretoria; 2005.

Nethathe BB, Ndip RN. Bioactivity of Hydnora africana on selected bacterial pathogens: Preliminary phytochemical screening. African Journal of Microbiology Research. 2011;5(18):2820-2826.