Moringa oleifera Derived Phytochemicals against 2-hydroxy-3-oxopropionate Reductase of Salmonella typhi Causing Typhoid
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Published
Jun 20, 2020
Page:
94-97
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Sonali Suchismita Behera
School of Applied Sciences, Centurion University of Technology and Management, Odisha, India.
Seema Suvadarshini
School of Applied Sciences, Centurion University of Technology and Management, Odisha, India.
Ipsita Aparajita Mohapatra
School of Applied Sciences, Centurion University of Technology and Management, Odisha, India.
Sonali Dash
School of Applied Sciences, Centurion University of Technology and Management, Odisha, India.
Akshaya Kumar Sahoo
School of Applied Sciences, Centurion University of Technology and Management, Odisha, India.
Soumyashree Nayak
School of Applied Sciences, Centurion University of Technology and Management, Odisha, India.
Meenakshee Mohanty
School of Applied Sciences, Centurion University of Technology and Management, Odisha, India.
Punya Prateek Majhi
School of Applied Sciences, Centurion University of Technology and Management, Odisha, India.
Srimay Pradhan
School of Applied Sciences, Centurion University of Technology and Management, Odisha, India.
Abstract
Phytochemicals from Moringa oleifera plant extract can cure Typhoid. It is caused by Salmonella typhi. Molecular docking method applied using “Biovia Discovery Studio”. “High positive values of -CDOCKER energy and -CDOCKER interaction energy” suggested that 4,8,12,16-tetramethylheptadecan-4-olide can effectively deactivate the 2-hydroxy-3-oxopropionate reductase enzyme thereby interrupting the life cycle of the organism.
Keywords:
Phytochemical, Moringa oleifera, Salmonella typhi, typhoid.
Article Details
How to Cite
Behera, S. S., Suvadarshini, S., Mohapatra, I. A., Dash, S., Sahoo, A. K., Nayak, S., Mohanty, M., Majhi, P. P., & Pradhan, S. (2020). Moringa oleifera Derived Phytochemicals against 2-hydroxy-3-oxopropionate Reductase of Salmonella typhi Causing Typhoid. Journal of Pharmaceutical Research International, 32(9), 94-97. https://doi.org/10.9734/jpri/2020/v32i930534
Section
Original Research Article
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Hussain I, Ullah R, Ullah R, Khurram M, Ullah N, Basee A, Khan F, Khattak M, Zahoor M, Khan J, Khan N. Phytochemical analysis of selected medicinal plant. African Journal of Biotechnology. 2011;10: 7487-7492.
Arulselvan P, Karthivashan G, Fakurazi S. Journal of Chemical and Pharmaceutical Research. 2013;5(7):233-239.
Das D, Das S, Pandey M, Bhattacharyay D. In silico analysis of phytochemicals from Mucuna pruriens (L.) DC against Mycobacterium tuberculosis causing tuberculosis. European Journal of Medicinal Plants; 2020.
Brinda OP, Deepu Mathew, Shylaja MR, Sangeetha Davis P, Anita Cherian K, Valsala PA. Isovaleric acid and avicequinone-C are chikungunya virus resistance principles in Glycosmis pentaphylla (Retz.) Correa. 2019;56(2): 111-121.