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Moringa oleifera Derived Phytochemicals against 2-hydroxy-3-oxopropionate Reductase of Salmonella typhi Causing Typhoid

  • Sonali Suchismita Behera
  • Seema Suvadarshini
  • Ipsita Aparajita Mohapatra
  • Sonali Dash
  • Akshaya Kumar Sahoo
  • Soumyashree Nayak
  • Meenakshee Mohanty
  • Punya Prateek Majhi
  • Srimay Pradhan

Journal of Pharmaceutical Research International, Page 94-97
DOI: 10.9734/jpri/2020/v32i930534
Published: 20 June 2020

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Abstract


Phytochemicals from Moringa oleifera plant extract can cure Typhoid. It is caused by Salmonella typhi. Molecular docking method applied using “Biovia Discovery Studio”. “High positive values of -CDOCKER energy and -CDOCKER interaction energy” suggested that 4,8,12,16-tetramethylheptadecan-4-olide can effectively deactivate the 2-hydroxy-3-oxopropionate reductase enzyme thereby interrupting the life cycle of the organism.


Keywords:
  • Phytochemical
  • Moringa oleifera
  • Salmonella typhi
  • typhoid.
  • Full Article - PDF
  • Review History

How to Cite

Behera, S. S., Suvadarshini, S., Mohapatra, I. A., Dash, S., Sahoo, A. K., Nayak, S., Mohanty, M., Majhi, P. P., & Pradhan, S. (2020). Moringa oleifera Derived Phytochemicals against 2-hydroxy-3-oxopropionate Reductase of Salmonella typhi Causing Typhoid. Journal of Pharmaceutical Research International, 32(9), 94-97. https://doi.org/10.9734/jpri/2020/v32i930534
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References

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DOI: 10.1017/S0140525X0999152X

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Das D, Das S, Pandey M, Bhattacharyay D. In silico analysis of phytochemicals from Mucuna pruriens (L.) DC against Mycobacterium tuberculosis causing tuberculosis. European Journal of Medicinal Plants; 2020.

Brinda OP, Deepu Mathew, Shylaja MR, Sangeetha Davis P, Anita Cherian K, Valsala PA. Isovaleric acid and avicequinone-C are chikungunya virus resistance principles in Glycosmis pentaphylla (Retz.) Correa. 2019;56(2): 111-121.
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