Moringa oleifera Derived Phytochemicals against 2-hydroxy-3-oxopropionate Reductase of Salmonella typhi Causing Typhoid

Main Article Content

Sonali Suchismita Behera
Seema Suvadarshini
Ipsita Aparajita Mohapatra
Sonali Dash
Akshaya Kumar Sahoo
Soumyashree Nayak
Meenakshee Mohanty
Punya Prateek Majhi
Srimay Pradhan

Abstract

Phytochemicals from Moringa oleifera plant extract can cure Typhoid. It is caused by Salmonella typhi. Molecular docking method applied using “Biovia Discovery Studio”. “High positive values of -CDOCKER energy and -CDOCKER interaction energy” suggested that 4,8,12,16-tetramethylheptadecan-4-olide can effectively deactivate the 2-hydroxy-3-oxopropionate reductase enzyme thereby interrupting the life cycle of the organism.

Keywords:
Phytochemical, Moringa oleifera, Salmonella typhi, typhoid.

Article Details

How to Cite
Behera, S. S., Suvadarshini, S., Mohapatra, I. A., Dash, S., Sahoo, A. K., Nayak, S., Mohanty, M., Majhi, P. P., & Pradhan, S. (2020). Moringa oleifera Derived Phytochemicals against 2-hydroxy-3-oxopropionate Reductase of Salmonella typhi Causing Typhoid. Journal of Pharmaceutical Research International, 32(9), 94-97. https://doi.org/10.9734/jpri/2020/v32i930534
Section
Original Research Article

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DOI: 10.1017/S0140525X0999152X

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