Michelia champaca L. Derived Phytochemicals against Peptidase Do of Bordetella pertussis Causing Cough

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Sanjeeb Kumar Dash
Sidhartha Ray
Smruti Ranjan Behera
Soumya Jal
Dipankar Bhattacharyay


Phytochemicals from Michelia champaca L. plant extract are traditionally used to cure cough.  Cough can be caused by many reasons. Caugh can be caused by the infection of Bordetella pertussis. The objective of the study is to identify the phytochemical of Michelia champaca capable of curing cough. Molecular docking method applied using “Biovia Discovery Studio”. “High positive values of -CDOCKER energy and -CDOCKER interaction energy” suggested that magnoflorine can effectively deactivate the peptidase Do enzyme which will interrupt the life cycle of the microorganism and inhibit the multiplication.

Phytochemical, Michelia champaca, Bordetella pertussis, cough

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How to Cite
Dash, S. K., Ray, S., Behera, S. R., Jal, S., & Bhattacharyay, D. (2020). Michelia champaca L. Derived Phytochemicals against Peptidase Do of Bordetella pertussis Causing Cough. Journal of Pharmaceutical Research International, 32(8), 133-135. https://doi.org/10.9734/jpri/2020/v32i830533
Original Research Article


Henrich J, Heine S, Norenzayan A. The weirdest people in the world? Behavioral and Brain Sciences. 2010;33(2-3): 61-83.

DOI: 10.1017/S0140525X0999152X

Hussain I, Ullah R, Ullah R, Khurram M, Ullah N, Basee A, Khan F, Khattak M, Zahoor M, Khan J, Khan N. Phytochemical analysis of selected medicinal plant. African Journal of Biotechnology. 2011;10: 7487-7492.

Arulselvan P, Karthivashan G, Fakurazi S. Journal of Chemical and Pharmaceutical Research. 2013;5(7):233-239.

Das D, Das S, Pandey M, Bhattacharyay D. In silico analysis of phytochemicals from Mucuna pruriens (L.) DC against Mycobacterium tuberculosis causing tuberculosis. European Journal of Medicinal Plants; 2020.

Brinda OP, Mathew D, Shylaja MR, Davis PS, Cherian KA, Valsala PA. Isovaleric acid and avicequinone-C are chikungunya virus resistance principles in Glycosmis pentaphylla (Retz.) Correa. Journal of Vector Borne Diseases. 2019;56(2):111.