Michelia champaca L. Derived Phytochemicals against Peptidase Do of Bordetella pertussis Causing Cough

Main Article Content

Sanjeeb Kumar Dash
Sidhartha Ray
Smruti Ranjan Behera
Soumya Jal
Dipankar Bhattacharyay

Abstract

Phytochemicals from Michelia champaca L. plant extract are traditionally used to cure cough.  Cough can be caused by many reasons. Caugh can be caused by the infection of Bordetella pertussis. The objective of the study is to identify the phytochemical of Michelia champaca capable of curing cough. Molecular docking method applied using “Biovia Discovery Studio”. “High positive values of -CDOCKER energy and -CDOCKER interaction energy” suggested that magnoflorine can effectively deactivate the peptidase Do enzyme which will interrupt the life cycle of the microorganism and inhibit the multiplication.

Keywords:
Phytochemical, Michelia champaca, Bordetella pertussis, cough

Article Details

How to Cite
Dash, S. K., Ray, S., Behera, S. R., Jal, S., & Bhattacharyay, D. (2020). Michelia champaca L. Derived Phytochemicals against Peptidase Do of Bordetella pertussis Causing Cough. Journal of Pharmaceutical Research International, 32(8), 133-135. https://doi.org/10.9734/jpri/2020/v32i830533
Section
Original Research Article

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DOI: 10.1017/S0140525X0999152X

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