Beet Root Derived Phytochemicals against Escherichia coli Causing Diarrhea

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Upendra Kumar Nayak
Smruti Ranjan Behera
Saswati Behera
Dipankar Bhattacharyay
Mukundjee Pandey


Phytochemicals from Beet Root (Beta vulgaris) plant extract are traditionally used to cure Diarrhea. It is caused by Escherichia coli. Molecular docking method applied using “Biovia Discovery Studio”. “High positive values of -CDOCKER energy and -CDOCKER interaction energy” suggested that caffeic acid can effectively deactivate the Shikimate dehydrogenase enzyme thereby interrupting the life cycle of the organism.

Phytochemical, Beta vulgaris, Shikimate dehydrogenase

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How to Cite
Nayak, U. K., Behera, S. R., Behera, S., Bhattacharyay, D., & Pandey, M. (2020). Beet Root Derived Phytochemicals against Escherichia coli Causing Diarrhea. Journal of Pharmaceutical Research International, 32(8), 129-132.
Original Research Article


Henrich J, Heine S, Norenzayan A. The weirdest people in the world? Behavioral and Brain Sciences. 2010;33(2-3):61-83. DOI: 10.1017/S0140525X0999152X

Hussain I, Ullah R, Ullah R, Khurram M, Ullah N, Basee A, Khan F, Khattak M, Zahoor M, Khan J, Khan N. Phytochemical analysis of selected medicinal plant. African Journal of Biotechnology. 2011;10: 7487-7492.

Arulselvan P, Karthivashan G, Fakurazi S. Journal of Chemical and Pharmaceutical Research. 2013;5(7):233-239.

Brinda OP, Mathew D, Shylaja MR, Davis PS, Cherian KA, Valsala PA. Isovaleric acid and avicequinone-C are chikungunya virus resistance principles in Glycosmis pentaphylla (Retz.) Correa. Journal of Vector Borne Diseases. 2019;56(2):111.

Vulić JJ, Ćebović TN, Čanadanović VM, Ćetković GS, Djilas SM, Čanadanović-Brunet JM, Tumbas VT. Antiradical, antimicrobial and cytotoxic activities of commercial beetroot pomace. Food & Function. 2013;4(5):713-721.

Ye S, von Delft F, Brooun A, Knuth MW, Swanson RV, McRee DE. The crystal structure of shikimate dehydrogenase (AroE) reveals a unique NADPH binding mode. Journal of Bacteriology. 2003; 185(14):4144-4151.

Das D, Das S, Pandey M, Bhattacharyay D. In silico analysis of phytochemicals from Mucuna pruriens (L.) DC against Mycobacterium tuberculosis causing tuberculosis. European Journal of Medicinal Plants; 2020.

Yaniv H, Gilvarg C. Aromatic biosynthesis XIV. 5-Dehydroshikimic reductase. Journal of Biological Chemistry. 1955;213(2):787-795.