Clinical and Humanistic Outcomes of Tuberculosis Treatment in a Nigerian Directly Observed Treatment Short Course Centre

Main Article Content

D. W. Dayom
M. K. Madison
M. A. Adeniyi
B. N. Joseph
C. N. Sariem
S. G. Mohammed
A. P. Lomak

Abstract

Background: Tuberculosis remains a major global health problem. It causes ill-health among millions of people each year and ranks alongside the human immunodeficiency virus (HIV) as a leading cause of death worldwide. The objective of the study was to evaluate the clinical and humanistic outcomes of tuberculosis treatment at the directly observed treatment short-course (DOTS) centre in Jos University Teaching Hospital.

Methods: Data for clinical outcomes was collected retrospectively at the directly observed treatment shortcouse centre of Jos University Teaching Hospital from a cross-section of patients’ folders who had been treated for tuberculosis at the study site for at least 12months as at 1st April to 30th September 2018 while a validated questionnaire was administered prospectively to a census population of tuberculosis patients still undergoing treatment between 1st October 2018 and 31st March 2019 to determine the humanistic outcomes. A descriptive data analysis was done using SPSS version 23 and proportions were tested using chi squared statistics with significance level set at P<0.05.

Results: The study revealed that tuberculosis treatment success in the centre was 76.33% which falls short of WHO standard of minimum of 85%. Patients taking tuberculosis treatment in the centre are satisfied with the services rendered to them and the improvement in their health conditions. Unfriendly attitude of some health care providers in the facility is an area for intervention.

Conclusion: Clinical and humanistic outcomes of tuberculosis treatment was found to be satisfactory in the facility owing to the level of treatment success and patient reported satisfaction with facility services and improvement in their health conditions.

Keywords:
Tuberculosis, treatment, clinical outcome, humanistic outcome.

Article Details

How to Cite
Dayom, D. W., Madison, M. K., Adeniyi, M. A., Joseph, B. N., Sariem, C. N., Mohammed, S. G., & Lomak, A. P. (2020). Clinical and Humanistic Outcomes of Tuberculosis Treatment in a Nigerian Directly Observed Treatment Short Course Centre. Journal of Pharmaceutical Research International, 32(11), 1-9. https://doi.org/10.9734/jpri/2020/v32i1130497
Section
Original Research Article

References

World Health Organization, Geneva, Switzaland. Global tuberculosis report; 2019.

Accessed 11thApril 2020

Available:https://apps.who.int/iris/bitstream/handle/10665/329368/9789241565714-eng.pdf?ua=1

Ferri F. Ferri’s differential diagnosis: A practical guide to the differential diagnosis of symptoms, signs and clinical disorders (2nd edition). Philadelphia PA: Elsevier/ Mosby; 2010.

[ISBN 0323076998]

World Health Organization, Latent tuberculosis infection: Updated and consolidated guidelines for programmatic management 2018, Geneva: Licence: CCBY-NC-SA 3.0 IGO.

Akeju OO, Wright SCD, Maja MT. Live experience of patients on Tuberculosis treatment in Tshwane, Gauteng province. University of Johannesburg; 2017.

Available:http://ees.elseview.com/hsag/default. Asp

Sulis G, Roggi A, Matteeth A, Raviglione MC. Tuberculosis: Epidemiology and control, mediter J. Haematol. Infect. Dis. 2017;6(1):e2104070.

DOI: 10.4048/MJ. HID 2014. 070

Onyedum CC, Alobu 1, Ukwaja KN. Prevalence of drug-resistant tuberculosis inNigeria: Asystematic review and meta- analysis. Plos One. 2017;12(7): E0180996.

DOI:/10.137/Journal. Prone. 0180996

Ani AE, Idoko J, Dalyop YB, Pitmang SL. Drug resistance profile of mycobacterium tuberculosis isolates from pulmonary tuberculosis patients in Jos, Nigeria. Transactions of The Royal Society of Tropical Medicine and Hygiene. 2009; 103(1):67–7. DOI:https://doi.org/10.1016/j.trstmh.2008.08.004

Center for disease control and prevention, core curriculum on Tuberculosis: What the clinician should know; 2012.

Available:https: www,cdc.gov/tb

World health organization. Tuberculosis DOTS treatment success; 2006.

Accessed on4th May, 2020

Available:https://www.who.int/whosis/whostat2006TuberculosisDOTSTreatmentSuccess.pdf

Anunnatsiri S, Chetchotisakd P, Wanke C. Factors associated with treatment out comes inpulmonary tuberculosis in northeastern Thailand, Southeast Asian Journal of Tropical Medicine and Public Health. 2005;36(2):324–330.

Palha PF, da Silva LM, Wysocki AD, Andrade RL, Protti ST, Scatena LM, Villa TC. Access to healthcare ser-vices for tuberculosis: Analysis of patient satisfaction. Rev Esc Enferm USP. 2012; 46(2):342–348.

Babikako HM, Neuhauser D, Katamba A, Mupere E. Patient satisfaction, feasibility and reliability of satisfaction questionnaire among patients with pulmonary tuberculosis inurban Uganda: A cross-sectional study. Health Res Policy Syst. 2011;9:6.

Ade S, Harries AD, Tre´bucq A, Ade G, Agodokpessi G, Adjonou C, Azon S, Anagonou S. National Profile and Treatment Outcomes of patients with extrapulmonary tuberculosis in be´nin. Plos One. 2014;9(4):e95603.

DOI:10.1371/journal.pone.0095603

Holden IK, Lillebaek T, Seersholm N, Andersen PH, Wejse C, Johansen IS. Predictors for Pulmonary Tuberculosis Treatment Outcome in Denmark 2009–2014 Scientific Reports. 2009;9(12995).

Onyeonoro U, Chukwu JN, Nwafor CC, Meka AO, Omotowo BI, Madichie NO, et al. Evaluation of patient satisfaction with tuberculosis services in Southern Nigeria. Health Services in Sights. 2015;8:25.

DOI:10.4137/HSI.S27177PMID:26508872

Umeokonkwo CD, Okedo-Alex IN, Azuogu BN, Rowland Utulu R, Adeke AS, Disu YO. Trend and determinants of tuberculosis treatment outcome in Tertiary hospital in Southeast Nigeria. J Infect Public Health; 2019.

DOI:https://doi.org/10.1016/j.jiph.2019.10.012(in press)

Murphy ME, Wills GH, Murthy S, Louw C, Bateson ALC, Hunt RD, McHugh TD, Nunn AJ, Meredith SK, Mendel CM, Spigelman M, Crook AM, Gillespie SH for the REMox TB consortium. Gender differences in tuberculosis treatment outcomes: Aposthoc analysis of the REMox TB study. BMC Medicine. 2018;16:189.

DOI:https://doi.org/10.1186/s12916-018-1169-5

Tanue EA, Nsagha DS, Njamen TN, Assob NJC. Tuberculosis treatment outcome andits associated factors among people living with HIV and AIDS in Fako Division of Cameroon. PLoS One. 2019;14(7): e0218800. DOI:https://doi.org/10.1371/journal.pone.0218800

Murdoch DM, Venter WDF, Van Rie A, Feldman C. Immune reconstitution inflammatory syndrome (IRIS): Review ofcommon infectious manifestations and treatment options. AIDS Research and Therapy. 2007;4:9.

DOI:10.1186/1742-6405-4-9

Ibrahim LM, Hadejia IS, Nguku P, Dankoli R, Waziri NE, Akhimien MO, Ogiri S et al. Factors associated with interruption of treatment among pulmonary tuberculosis patients in Plateau State, Nigeria. Pan Afri. Med J. 2014;17:78.

Umar NA, Fordham R, Abubakar I, Bachmann M. The indirect cost due to pul-monary tuberculosis in patients receiving treatment in Bauchi State—Nigeria. Cost Eff ResourAlloc. 2012;10:6.

World Health Organization. Tuberculosis - the Global Burden, World Health Organization, Geneva, Switzerland; 2005.

Alturki M, Khan TM. A study investigating the level of satisfaction with the health services provided by the pharmacist at ENT hospital, Eastern Region Alahsah, Kingdom of Saudi Arabia. Saudi Pharm J. 2013;21:255–260.

Schoenfelder T, Klewer J, Lugler J. Determinants of patient satisfaction: A studyamong39 hospitals inan in-patient setting in Germany. Int J Qual Health Care. 2011;23(5):503–509