Phenolic Content and Enzyme Inhibition Activities Barbarea auriculata var. paludosa, B. integrifolia and B. plantaginea (Brassicaceae)'s

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Merve Badem
Sıla Ozlem Sener
Nuriye Korkmaz
Seyda Kanbolat
Sermet Yildirmiş
Ufuk Ozgen
Rezzan Aliyazicioglu
Ali Kandemir


Barbarea genus has been presented about 12 species, 9 taxon are endemic, in Turkey. In this sudy, enzyme inhibition was carried out on methanolic extract, chloroform extract, ethyl acetate extract, and the remaining aqueous phases from the aerial parts of B. auriculata var paludosa, B. integrifolia, and B. plantaginea species and HPLC studies were carried on their methanolic extract in the present study for the first time. Phenolic compounds were determined using reverse phase-high performance liquid chromatography (RP-HPLC). p-OH benzoic acid, vanilic acid, syringaldehyde, coumaric acid, synapic acid and benzoic acid were detected as major phenolic compounds in the species. Assay of enzyme inhibition activities were done using spectrophotometric methods. Results of these studies reveal that the extracts from these species have moderate tyrosinase, AChE and BuChE inhibitory activity. In the biological activity studies, it was observed that B. integrifolia was the highest activity.

Barbarea, brassicaceae, enzyme ınhibition, phytochemical

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How to Cite
Badem, M., Sener, S. O., Korkmaz, N., Kanbolat, S., Yildirmiş, S., Ozgen, U., Aliyazicioglu, R., & Kandemir, A. (2020). Phenolic Content and Enzyme Inhibition Activities Barbarea auriculata var. paludosa, B. integrifolia and B. plantaginea (Brassicaceae)’s. Journal of Pharmaceutical Research International, 32(9), 86-93.
Original Research Article


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