Anti-inflammatory Potentials of Fibraurea tinctoria Leaves Extract in Experimental Rats or Animals

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Fahad I. Al-Saikhan


The activity of the hydroalcoholic extract of Fibraurea tinctoria leaves and anti-inflammatory was investigated. We utilized rats for which oedema was induced by carrageenan.  The extract of Fibraurea tinctoria leaves was administered orally at doses of 100, 200 and 400 mg/kg. Paw oedema was significantly minimized using all prepared doses of the extract administered. The 400 mg/kg dose producing the highest oedema reduction. The Percent Inhibition with hydroalcoholic extract of Fibraurea tinctoria and Indomethacin were 67.6% and 68.49% respectively. We concluded that this study has established the anti-inflammatory activity of hydroalcoholic extract of Fibraurea tinctoria leaves. I believe the results justify the traditional uses of the plant in the treatment of wounds and inflammation.

Anti-inflammatory, Fibraurea tinctoria, carrageenan, hydroalcohol

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How to Cite
Al-Saikhan, F. I. (2020). Anti-inflammatory Potentials of Fibraurea tinctoria Leaves Extract in Experimental Rats or Animals. Journal of Pharmaceutical Research International, 32(8), 79-83.
Original Research Article


Sosa S, Balick MJ, Arrigo R, Esposito RG, Pizza C, Altinier GA. Screening of the topical anti-inflammatory activity of some Central American plants, J Ethnopharmacol. 2002;8:211-5.

Kayaalp SO. Medical pharmacology, in terms of rational treatment. Ankara, Hacettepe-Tas Ltd. Sti; 1998.

Kirtikar KR, Basu BD. Indian medicinal plants. International Book Distributors, New Delhi. 1990;2724-7.

Jose VM, Antony TT. Recent trends in the utilization of ‘NSAIDs’ in a tertiary care hospital, Indian J Pharmacol. 2003;35: 318–9.

Rang HP, Dale MM, Ritter JM, Flower RJ. Rang and Dale's Pharmacology. 6th ed. Elsevier Publications, Anti-inflammatory and immunosuppressant drugs, Chapter 14, 6th ed. 2008;226–45.

Gupta AK, Tandon N. Reviews on Indian medicinal plants. Indian Council of Medicinal Research. 2004;1:312.

Hajra PK, Nair VJ, Daniel P. Flora of India, Calcutta: Botanical Survey of India. 1997; 1:264.

Alcatraz MJ, Jimenez MJ. Flavonoids as anti-inflammatory agents. Fitoterapia. 1988;59:25-38.

Burke A, Smith E, Fitz Gerald GA. Analgesic-antipyretic and anti-inflammatory agents, pharmacotherapy of gout. The Pharmacological basis of therapeutics. 11th ed. New York. 2006;671-715.

Mandal SC, Maity TK, Das J, Saba BP, Pal M. Anti-inflammatory evaluation of Ficus racemosa Linn. leaf extract, J Ethnopharmacology. 2000;72(1-2):87-92.

Patil VV, RB Pimprikar and VR Patil. Pharmacognostical studies and evaluation of anti-inflammatory activity of Ficus benghalensis Linn. J Young Pharm. 2009; 1(1):49-53.

Bolton S. Analysis of variance. Pharmaceutical statistics: Practical and clinical applications. Drugs and Pharmaceutical Sciences Series. Basel: Marcel Dekker, In Swarbrick J. 1997;215-265.

Winter CA, Risley EA, Nuss GW. Carrageenan-induced edema in hind paw of rat as an assay for anti-inflammatory drugs. Proc Soc Expt Biol Med. 1962; 111:544–7.

Kirtikar KR, Basu BD. Indian medicinal plants. 2nd ed. Dehradun: International Book Distributors. 1999;499–502.