Formulation and Evaluation Thermoreversible Gel of Antifungal Agent for Treatment of Vaginal Infection

Main Article Content

Manisha V. Patil
Rahul L. Jadhav
Siraj N. Shaikh
Santosh N. Belhekar

Abstract

Aims: The aim this research work is to formulate and evaluate thermoreversible gel of antifungal agent Clotrimazole for treatment of vaginal infection.

Place and Duration of Study: Department of Biopharmaceutics, Government College of Pharmacy, Karad, Maharashtra, India, between June 2009 and July 2010.

Methodology: Different Formulations of thermoreversible gel of antifungal agent Clotrimazole were prepared by using various concentrations of ethanol, PEG 400, sodium dodecyl sulphate, polycarbophil and pluronic F 127 and pluronic F 68. The gel formulations were subjected for evaluation on the basis of rheological behaviour, mucoadhesive behaviour, in-vitro performance.

Results: The results indicate that Polymers such as polycarbophil, PEG- 400 in various concentrations to prepare formulations were found to release drug for period over 12 hrs. Without getting dislodged. The formulations have satisfactory rheological behavior and their diffusion profile is comparable to the marketed gel formulation. Significant difference was observed in the rheological behavior of formulations. Gel strength, spreadability, mucoadhesive strength of formulation B and C were desirable. Drug diffusion of formulation B and C were 95.2% release after 11 hrs 98.5% release after 11 hrs, respectively which was good as compared to marketed formulation showing drug diffusion of 102.2% after 10 hrs.

Conclusion: On basis of the results we concluded that developed thermoreversible gel of Clotrimazole will be better alternative to conventional dosage form Clotrimazole & will improve patient compliance.

Keywords:
Antifungal, pluronic F-127, clotrimazole, thermoreversible gel, vaginal infection, spreadability.

Article Details

How to Cite
Patil, M. V., Jadhav, R. L., Shaikh, S. N., & Belhekar, S. N. (2020). Formulation and Evaluation Thermoreversible Gel of Antifungal Agent for Treatment of Vaginal Infection. Journal of Pharmaceutical Research International, 32(2), 58-66. https://doi.org/10.9734/jpri/2020/v32i230404
Section
Original Research Article

References

Alamdar Hussain, Fakhrul Ahsan. The vagina as a route for systemic drug delivery. J. Controlled Release. 2005;103: 301-313.

Das J, Neves MF, Bahia. Gels as vaginal drug delivery systems. Int. J. Pharm. 2006; 318:1-14.

Das K, Basak S, Ray S. A study on superficial fungal infection from west bengal: A brief report. J Life Sci. 2009;1: 51-55.

Escobar-Chavez JJ, Lopez-Cervantes M, Naik A. Applications of thermo-reversible pluronic F-127 gels in pharmaceutical formulations. J Pharm. Sci. 2006;9(3):32-35.

Tomida H, Shinohara M, Kuwada N, Kiryu S. In vitro release characteristics of diclofenac and hydrocortisone from pluronic F 127 gels. Acta Pharm Suec. 1987;24:263-272.

Patel J, Patel B, Banwait H, Parmar K, Patel M. Formulation and evaluation of topical aceclofenac gel using different gelling agent. Int J Drug Dev Res. 2011; 3:156-164.

Seham S, Abd EIHady, Nahed D. Mortada, Noha M. Zaki. Development of in situ gelling and mucoadhesive mebeverine hydrochloride solution for rectal administration. Saudi Pharm. J. 2003;11: 159-171.

Young-Joon Park, Chul Soon Yong, Hak-Mi Kim. Effect of sodium chloride on the release, adsorption and safety of diclofenac sodium delivered by poloxamer gel. International J Pharmaceutics. 2003; 263:105-111

Bilensoy Erem, Abdur Rouf M, Vural Imran. Mucoadhesive, thermoreversible, prolonged-release vaginal gel for clotrimazole: -cyclodextrin complex. AAPS Pharm. Sci. Tech. 2006;7(2):339-358.

Jung Yun Chang, Yu-Kyoung OH, Han-gon Choi. Rheological evaluation of thermosensitive and mucoadhesive vaginal gels in physiological conditions. Inter-national J Pharmaceutics. 2002;241:155-163.

Claudi Valenta, Constantia E. Kast, Irene Harich. Development and in vitro evaluation of a mucoadhesive vaginal delivery system for progesterone. J. Controlled Release. 2001;77:323-332.

Shruti Chopra, Sanjay K. Motwani, Zeenat Iqbal. Optimisation of polyherbal gels for vaginal drug delivery by Box-Behnken statistical design. Eur. J. Pharm. & Biopharm. 2007;67:120-131.

Gilbert JC, Hadgraft J, Bye A, Brookes LG. Drug release from Pluronic F-127 gels. Int J Pharm. 1986;32:223-228.

Ahuja N, Saini V, Bishnoi VK, Garg A, Hisoria M, Sharma J, Nepali K. Formulation and evaluation of diclofenac sodium gel by using natural polymer. Rasāyan J Chem. 2008;1:564-566 15.

Meshali M, Abdel Aleem H, Sakr F, Nazzal S, El-Malah Y. Effect of gel composition and phonophoresis on the transdemal delivery of ibuprofen: In vitro and In vivo evaluation. Pharm Dev Technol. 2011; 16:93-101.

Mohammed FA. Topical permeation characteristics of diclofenac sodium from NaCMC gels in comparison with conventional gel formulations. Drug Dev Ind Pharm. 2001;27:1083-1097.

Deveda P, Jain A, Vyas N, Khambete H, Jain S. Gellified emulsion for sustain delivery of itraconazole for topical fungal diseases. International Journal of Pharmacy and Pharmaceutical Sciences. 2010;2:104-112.

El Gendy AM, Jun HW, Kassem AA. In vitro release studies of flurbiprofen from different topical formulations. Drug Dev Ind Pharm. 2002;28:823-831.