Formulation and Characterization of Poly Sulfoxyamine Grafted Chitosan Coated Contact Lens

Main Article Content

Rahul Laxman Jadhav
Sonali Gulab Sonwalkar
Manisha Vyankatrao Patil
Siraj N. Shaikh
Santosh N. Belhekar

Abstract

Aim: The aim this research work is to formulate and characterize Poly Sulfoxyamine Grafted Chitosan Coated contact Lens.

Methodology: Poly Sulfoxyamine Grafted Chitosan was used for coating the Lens & converting it in to Antimicrobial Lenses. Poly Sulfoxyamine Grafted Chitosan was performed in the presence of pyridine and further treatment with ammonia during reaction of Thionyl chloride & chitosan. The UV light interference, visible light transmission and antimicrobial evaluation were studied.

Results: The results indicate that Contact lenses prepared with Modified Poly Sulfoxyamine Grafted Chitosan absorbed some UV radiation & does not interfere with visible region. Due to the antimicrobial activity of modified Chitosan, the growth and transmission of micro organisms are reduces in coated Lens as compared to uncoated Lens.

Conclusion: On basis of the results we concluded that Modified Poly Sulfoxyamine Grafted Chitosan might be used as coating material or material for making contact Lenses which will be less susceptible for microbial contamination.

Keywords:
Poly sulfoxyamine grafted chitosan, contact lens, antimicrobial activity, UV light, chitosan.

Article Details

How to Cite
Jadhav, R. L., Sonwalkar, S. G., Patil, M. V., Shaikh, S. N., & Belhekar, S. N. (2020). Formulation and Characterization of Poly Sulfoxyamine Grafted Chitosan Coated Contact Lens. Journal of Pharmaceutical Research International, 32(2), 49-57. https://doi.org/10.9734/jpri/2020/v32i230403
Section
Short Research Article

References

Maulvi FA, Lakdawala DH, Shaikh AA, Desai AR, Choksi HH, Vaidya RJ, et al. In vitro and in vivo evaluation of novel implantation technology in hydrogel contact lenses for controlled drug delivery. Journal of Controlled Release. 2016;226: 47-56.

Dart JK, Stapleton F, Minassian D. Contact lenses and other risk factors in microbial keratitis. Lancet. 1991;338(8768):650-53.

Tranoudis I, Efron N. In-eye performance of soft contact lenses made from different material. Contact Lens and Anterior Eye. 2004;27(3):133–148.

Paugh JR. Equivalent oxygen percentage as a function of hydration in hydrogel lenses: An in vivo study. Optom Vis Sci. 1992;69:805-10.

Andrasko G. The amount and time course of soft contact lens dehydration. J Am Optom Assoc. 1982;53:207.

Refojo MF. The relationship of linear expansion to hydration of hydrogel contact lenses. Contact Intraocular Lens Med J. 1975;1:153-62.

Maulvi FA, Soni TG, Shah DO. A review on therapeutic contact lenses for ocular drug delivery. Drug Delivery. 2016;1(10):124-132.

Fatt I, Chaston J. Swelling factors of hydrogels and the effect of deswelling (drying) in the eye on power of a soft contact lens. Int Contact Lens Clin. 1982;9: 146–53.

Timberlake GT, Doane MG, Bertera JH. Short-term, low-contrast visual acuity reduction associated with in vivo contact lens drying. Optom Vis Sci. 1992;69(10): 755–60.

Amos CF, George MD. Clinical and laboratory testing of a silver-impregnated lens case. Contac Lens and Anteri. 2006;29(5):247-255.

Weisbarth RE, Gabriel MM, George M, et al Creating antimicrobial surfaces and materials for contact lenses and lens cases. Eye Contact Lens. 2007;33(6):426-429.

Mathews SM, Spallholz JE, Grimson MJ, et al. Prevention of bacterial colonization of contact lenses with covalently attached selenium and effects on the rabbit cornea. Cornea. 2006;25(7):806-814.

Baveja JK, Willcox MDP, Hume EBH, Kumar N, et al, Furanones as potential anti-bacterial coating on biomaterials. Biomaterials. 2004;25(20):5003-5012.

Jadhav RL, Patil MV, Yadav AV. Poly sulfoxyamine grafted chitosan as bactericidal dressing for wound healing. Asian Journal of Pharmacy. 2019;32(1): 127-132.

Maulvi FA, Lakdawala DH, Shaikh AA, Desai AR, Choksi HH, Vaidya RJ, et al. In vitro and in vivo evaluation of novel implantation technology in hydrogel contact lenses for controlled drug delivery. Journal of Controlled Release. 2016;226: 47-56.

Kocela A, Miedziński R, Filipecka K, et al. Analysis of free volumes and light transmission in hydrogel and silicone-hydrogel polymer contact lenses. Optica Applicata. 2016;Xlvi(1).

Turner Dc, Heaton JC, Vanderlaan DG, et al, Contact lens coating selection and manufacturing process. United State Patent, US 6,478,423 B1. 2002;12.

Baranowski P, Karolewicz B, Gajda M, Pluta J. Ophthalmic drug dosage forms characterization and research method. The Sci World J. 2014;14.

Filipecki J, Kocela A, Korzekwa W. Study of free volumes of polymer hydrogel and -silicone-hydrogel contact lenses by means of the positron annihilation lifetime spectroscopy method. Polimery W. Medycrynine. 2014;44(4):255-60.

Busscher HJ, Hooymans MM. Surface thermodynamics and adhesion forces governing bacterial transmission in contact lens related microbial keratitis. J Col Int Sci. 2011;38(2):230-237.