Cytotoxic Activity of Some Spirooxindole-4H-pyran Derivatives

Main Article Content

Zeinab Faghih
Zahra Faghih
Masoomeh Divar
Soghra Khabnadideh


Aims: Isatin is a honored scaffold and one of the most favorable class of heterocyclic systems that possesses many interesting biological activities and well-tolerated in humans. Here a series of fifteen spirooxindole-4H-pyran derivatives containing both isatin and pyran moieties (ICa-ICo) will be examine for their anti-cancer activity.

Study Design: Cytotoxic evaluation of some spirooxindole-4H-pyran derivatives in two cancerous cell lines. 

Place and Duration of Study: Pharmaceutical Science Research Center and Shiraz Institute for Cancer Research, Medical School in Shiraz University of Medical Sciences, Shiraz, Iran, between June 2018 and July 2019.

Methodology: MTT assay was used to evaluate the cytotoxic activities of these compounds. The anticancer properties of the tested compounds were determined using A549 and MCF-7 cell lines.

Results: Among the tested compounds ICc, ICdand ICfshowed the best cytotoxic activities  against both cancerous cell lines. Compounds IChand ICj showed desirable cytotoxic activities against A549 cell line. Compound ICb showed desirable cytotoxic activities against MCF-7 cell line.

Conclusion: We conclude that the isatin-linked pyran analog can serve as a prototype molecule for further development of a new class of anticancer agents.

Spirooxindole-4H-pyran, cytotoxic activity, MTT

Article Details

How to Cite
Faghih, Z., Faghih, Z., Divar, M., & Khabnadideh, S. (2019). Cytotoxic Activity of Some Spirooxindole-4H-pyran Derivatives. Journal of Pharmaceutical Research International, 31(6), 1-6.
Original Research Article


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