Comparison of the Effect of Pregabaline and Diclofenac Suppository on Pain Relief after Elective Cesarean Section

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Asadollah Shakeri
Maryam Razavi
Zeinab Mirkahnuj


Introduction: Cesarean section is one of the most common major surgeries performed worldwide. Considering the importance of post-cesarean pain, finding a drug that can provide the patient with the least amount of complications can make the patient feel the least pain and most relaxation. The aim of this study was to compare the effect of pregabaline and diclofenac suppository on pain relief after elective cesarean section with spinal anesthesia.

Methods: This study was performed in 2016 on 100 women admitted to Ali Ibn Abi Talib Hospital due to elective cesarean section. Patients were divided into two groups of 100mg rectal diclofenac half an hour before surgery and 300mg pre-gabbaline group. Data were analyzed using SPSS software. Probability level lower than 0.05 was considered significant.

Results: The mean score of after surgery pain at 6 and 12 hours after surgery in the diclofenac group was significantly lower than in the pregabaline group, but at 18 and 24 hours, the difference between the two groups was not statistically significant. The mean dose of pethidine used in the diclofenac group was significantly lower than the pregabaline group. Maternal satisfaction was significantly higher in the diclofenac group.

Conclusion: According to the results of this study, diclofenac has a stronger antinociceptive effect than pregabalin.

Cesarean section, diclofenac, pregabalin.

Article Details

How to Cite
Shakeri, A., Razavi, M., & Mirkahnuj, Z. (2019). Comparison of the Effect of Pregabaline and Diclofenac Suppository on Pain Relief after Elective Cesarean Section. Journal of Pharmaceutical Research International, 31(6), 1-6.
Original Research Article


Fakor F, Farzi F, Abdollahzadeh M, Golrizan F, Kazemnejad E. The effect of Transversus Abdominis Plane (TAP) block with bupivacaine 25% on post cesarean pain. J Guil Uni Med Sci. 2014;23(91):53-60.

Jakobi P, Weiner Z, Solt I, Alpert I, Itskovitz-Eldor J, Zimmer EZ. Oral analgesia in the treatment of postcesarean pain. Eur J Obstet Gynecol Reprod Biol. 2000;93(1):61-4.

Miller RD, Pardo M, Stoelting RK. Basics of anesthesia. 6th ed. Philadelphia: Elsevier; 2011.

Stoelting RK, Miller RD Basics of anesthesia. 4th ed. New York: Churchil Livingstone. 2005;230-45.

Gramke HF, De Rijke JM, Van Kleef M. The prevalence of postoperative pain in a cross-sectional group of patients after day case surgery in a university hospital. Clin J Pain. 2007;23:543-48.

Kelly DJ, Ahmad M, Brull SJ. Preemtive analgesia I: Physiological pathways and pharmacological modalities. Can J Anaesth. 2001;48(10):1000-10

Woolf CJ, Chong MC. Preemtive analgesia--treating postoperative pain by preventing the establishment of central sensitization. Anaesth Analg 1993;77(2): 362-79.

Rahmanpoor H, Hosseini SN, Mousavinasab SN, Tadayon P, Karimi F. Comparison of diclofenac with pethidine on the pain after cesarean section. International Journal of Pharmacology. 2007;3(2):201-3.

Gajraj NM, Dabpm F. Pregabalin: Its pharmacology and use in pain management. Anesth Analg. 2007;105: 1805-15.

Mahran E, Hassan ME. Comparison of pregabalin versus ketamine in postoperative pain management in breast cancer surgery. Saudi J Anaesth. 2015;9(3):253-6.

Faraji R, Haryalchi K, Fashkhami F, Pourmarzi D. Comparison of Low Dose Gabapentin and Diclofenac Efficacy for Postoperative Pain Reduction after Abdominal Hysterectomy: A Randomized Clinical Trial. 2015;3:24(93):63-69.

Alami A, Moradi Z, Delshad Noghabi A, Hamzei A. Comparison between sedation-Agitation and visual analog scales in determination of sedation status of patients. Horizon Med Sci. 2016;22(2):159-164.

Rabiee S, Naghibzadeh N. The effect of rectal diclofenac in post-cesarean analgesia and reducing the patients opioid sedative needs. Avicenna J Clin Med. 2006;13(3):15-18.

Vyankatesh J, Ramesh V, Ganesh KH, Vikram SH, Jamadar NP. Comparative study of analgesic efficacy of rectal suppository of tramadol versus diclofenac in suppressing postoperative pain after Cesarean section. Int J HealthBiomed Res. 2013;1(2):32-37.

Thienthong S, Chongsomchai CH, Kemthong W. A placebo-controlled, double-blind, randomized study of single-dose intravenous diclofenac for pain relief after a cesarean section. Acta Anaesthesiologica Taiwanica. 2012; 50:150-152.

Akhavanakbari G, Entezariasl M, Isazadehfar, K, Kahnamoyiagdam F. The effects of indomethacin, diclofenac and acetaminophen suppository on pain and opioids consumption after cesarean section. Perspect Clin Res. 2013;4:136-41.

Rao ST, Wali M, Sachan V. Comparison of Post-Operative Analgesic Effects of Pre-Operative Pregabalin with Diclofenac in Head and Neck Surgery. Medical Science. 2013;2(8):12-18.

Mohamed El –guoshy M, Mohamed Ali Stohy ELSM, Hussein HA, Sale K, Saleh AA, Mahmoud Mohamed Mohamed Abdallah Seliem. Clinical comparative study of the effect of preoperative pregabalin on reduction of the incidence of headache after spinal anesthesia in cesarean section. The Egyptian Journal of Hospital Medicine. 2018;73(4):6507-6514.

Darvish H, Memar Ardestani B, Mohammadkhani Shali S, Tajik A. Analgesic efficacy of diclofenac and paracetamol vs. meperidine in cesarean section. Anesth Pain Med. 2013;4(1): e9997.