The Use of Topical Clobetasol among the Women in Hail Region, Saudi Arabia: A Cross-sectional Study on Knowledge and Practice

Main Article Content

Mukhtar Ansari
Subish Palaian
Mohamed Izham Mohamed Ibrahim
Pathiyil Ravi Shankar


Aims: The current study aimed to evaluate female consumers’ knowledge and practice about harmful effects of topical clobetasol applied on the face for cosmetic purposes. 

Study Design: Cross-sectional study. 

Place and Duration of Study: Randomly selected community pharmacies, well known cosmetic shops and shopping malls of Hail region, Saudi Arabia from March 2018 to June 2018.

Methodology: We included 391 participants who only used ‘clobetasol’ as a topical steroid at the time of interview, responses were collected as per the study tool and analyzed using SPSS for Windows, Version 16.0. Chicago, SPSS Inc..

Results: Relatives (28.1%), friends (25.6%) and community pharmacists (15.6%) contributed significantly towards using topical clobetasol cream. In 86.2% of the cases, the pharmacists who dispensed clobetasol did not inform the consumer about the harmful effects. Purchasing the cream without prescription (P = 0.025) was significantly associated with age. In the study, 41.9 % of the females experienced adverse effects, with the commonest one being hair growth on face (23%) followed by dermatrophy (14.8%); with a significant association with frequency of use (p<0.001).

Conclusion: There was haphazard use of topical clobetasol by females and they were unaware of the adverse effects. Over-the-counter availability of topical clobetasol, lack of knowledge about harmful effects, and lack of counseling on its safety profile by community pharmacists and other healthcare professionals are mainly responsible for its misuse and harmful consequences.

Adverse effects, clobetasol, consumers, corticosteroids, Saudi Arabia, topical.

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How to Cite
Ansari, M., Palaian, S., Ibrahim, M. I. M., & Shankar, P. R. (2019). The Use of Topical Clobetasol among the Women in Hail Region, Saudi Arabia: A Cross-sectional Study on Knowledge and Practice. Journal of Pharmaceutical Research International, 31(6), 1-7.
Original Research Article


Sulzberger MB, Witten VH. The effect of topically applied compound F in selected dermatoses. J Invest Dermatol. 1952; 19(2):101-102.

Becker DE. Basic and clinical pharmacology of glucocorticosteroids. Anesth Prog. 2013;60(1):25-31.

Sharma R, Abrol S, Wani M. Misuse of topical corticosteroids on facial skin: A study of 200 patients. J Dermatol Case Rep. 2017;11(1):5-8.

Hengge UR, Ruzicka T, Schwartz RA, Cork MJ. Adverse effects of topical glucocorticosteroids. J Am Acad Dermatol. 2006;54(1):1-15.

Jha AK, Sinha R, Prasad S. Misuse of topical corticosteroids on the face: a cross-sectional study among dermatology outpatients. Indian Dermatol Online J. 2016;7(4):259-63.

Dey VK. Misuse of topical corticosteroids: A clinical study of adverse effects. Indian Dermatol Online J. 2014;5(4):436-40.

Ladizinski B, Mistry N, Kundu RV. Widespread use of toxic skin lightening compounds: medical and psychosocial aspects. Dermatol Clin. 2011;29(1):111- 23.

Lu H, Xiao T, Lu B, Dong D, Yu D, Wei H, et al. Facial corticosteroid addictive dermatitis in Guiyang City, China. Clin Exp Dermatol. 2010;35(6):618-21.

Dermovate Cream.
Accessed August 29, 2019

Hawsawi KA, Alaauldeen S, Albarnawi N, Mashrai H, Alosaimi R, Alsufyani H, et al. Prevalence of misuse of topical corticosteroids among populations in western region of Saudi Arabia. Int J of Adv Res. 2017;5(2):297-307.

Alshehri MD, Almutairi AT, Alomran AM, Alrashed BA, Kaliyadan F. Over-the-counter and prescription medications for acne: a cross-sectional survey in a sample of university students in Saudi Arabia. Indian Dermatol Online J. 2017;8(2):120-23.

Khalifeh MM, Moore ND, Salameh PR. Self‐medication misuse in the Middle East: a systematic literature review. Pharmacol Res Perspect. 2017;5(4):e00323.

Majed D, Alnujaidi M, Almohammadi N, Kokandi AA. Use of topical steroids on the face among university students in Saudi Arabia. Biomedical Research. 2018; 29(13):2786-89.

Sendrasoa FA, Ranaivo IM, Andrianarison M, Raharolahy O. Misuse of Topical Corticosteroids for Cosmetic Purpose in Antananarivo, Madagascar. Biomed Res Int. 2017:9637083.

Mahdy A, Hussain N, Al Khalidi D, Said ASA. Knowledge, attitude, and practice analysis of corticosteroid use among patients: A study based in the United Arab Emirates. National Journal of Physiology, Pharmacy and Pharmacology. 2017;7(6): 562-68.

Lau WM, Donyai P. Knowledge, attitude and advice-giving behaviour of community pharmacists regarding topical corticosteroids. Pharmacy(basel). 2017; 5(3):E41.

Amodu MO, Bolori MT, Ahmad IM, Kale A, Kuchichi A. Knowledge, attitude and practice of skin whitening among female university students in Northeastern Nigeria. Open Access Library Journal. 2018;5(4):e4501.

Rathi SK, D'Souza P. Rational and ethical use of topical corticosteroids based on safety and efficacy. Indian J Dermatol. 2012;57(4):251-59.

Abraham A, Roga G. Topical steroid-damaged skin. Indian J Dermatol. 2014; 59(5):456-59.

Bains P. Topical corticosteroid abuse on face: A clinical study of 100 patients. International Journal of Research in Dermatology. 2016;2(3):40-45.