Journal of Pharmaceutical Research International <p style="text-align: justify;"><strong>Journal of Pharmaceutical Research International (ISSN:&nbsp;2456-9119)</strong> is dedicated to publish&nbsp;high quality papers (<a href="/index.php/JPRI/general-guideline-for-authors">Click here for Types of paper</a>)&nbsp;in all areas of pharmaceutical Science including pharmaceutical drugs, community pharmacy, hospital pharmacy, clinical pharmacy, compounding pharmacy, consultant pharmacy, internet pharmacy, veterinary pharmacy, nuclear pharmacy, military pharmacy, pharmacy informatics, pharmaceutics, medicinal chemistry, pharmacognosy, pharmacotherapy, pharmacodynamics, pharmacokinetics, clinical pharmacology, neuropharmacology, psychopharmacology, pharmacogenetics, pharmacogenomics, pharmacoepidemiology, toxicology, theoretical pharmacology, posology, pharmacognosy, behavioral pharmacology, environmental pharmacology, medicine development and safety testing, drug legislation and safety, pharmaceutical microbiology, pharmaceutical molecular biology, pharmaceutical biotechnology.&nbsp;The journal also encourages the submission of useful reports of negative results. This is a quality controlled,&nbsp;OPEN&nbsp;peer reviewed, open access INTERNATIONAL journal.</p> SCIENCEDOMAIN international en-US Journal of Pharmaceutical Research International 2456-9119 A Giant Solitary Fibrous Tumor of the Liver with Metastasis and Local Recurrence <p>Solitary fibrous tumor (SFT) is a rare type of mesenchymal neoplasm. Although the majority of SFTs are benign, some cases have shown characteristics of malignant neoplasms. Weight loss, fatigue, and upper abdominal bloating are the main signs of these lesions. Clinical and radiographic features are not sufficient for the diagnosis of hepatic SFT and the definitive diagnosis depends on histopathological sampling and immunohistochemistry. One of the main issues in the diagnosis of this tumour is the ability of this tumour to grow to large sizes. A 69-year-old male presented to the clinic 2 years earlier with episodes of hypoglycemia and loss of consciousness. The symptoms improved after receiving glucose. The patient diagnosed as rare solitary fibrous tumour of the liver, a giant (10 × 10 cm in diameter) round and well-defined lesion in the left lobe of the liver which was obvious in magnetic resonance imaging (MRI). Surgery is the most common line of treatment for this disease and there is no evidence regarding the effectiveness of other approaches. According to the scarcity of hepatic SFT, long-term prognosis in these patients is highly challenging. Here, we present the case of a 69-year-old male patient with hepatic SFT with metastasis and local recurrence. In the very rare malignant form of liver solitary fibrous tumour which is surgically unresectable, liver transplantation is one of the potential options but maybe not amenable due to the malignant behaviour of the disease. Role of debulking surgery is also not clear in this situation.</p> Mostafa Hoseini Hossein Fahimi Mohammad Vaziri Farnaz Vosough Borna Farazmand Fereshteh Vosough Behnood Farazmand ##submission.copyrightStatement## 2020-04-06 2020-04-06 18 23 10.9734/jpri/2020/v32i430420 Exploration of the Chemical Potential and Antioxidant Activity of Some Plants Used in the Treatment of Male Infertility in Southern Benin <p>Antioxidants are a family of substances that can neutralize free radicals and prevent and/or treat diseases associated with oxidative stress such as male’s infertility. Medicinal plants are one of the main sources of antioxidants.</p> <p><strong>Aim:</strong> This work was aimed at evaluating the chemical and antioxidant potential of different extracts from some plants used in traditional Beninese medicine for the treatment of male infertility.</p> <p><strong>Materials and Methods:</strong> The study was carried out on aqueous, hydro-ethanolic and ethanolic extracts from of the roots of <em>Gardenia ternifolia (G. ternifolia), </em>the whole plant of <em>Cassytha filiformis (C. filiformis),</em> the leaves of <em>Rourea coccinea (R. coccinea)</em> and the seed of <em>Garcinia kola (G .kola).</em> Quantification of the total polyphenols and flavonoids content of these extracts was evaluated respectively by the method using Folin Ciocalteu and the method using Aluminum trichloride. The antioxidant activity of the extracts was evaluated by molecular spectrophotometry using the free radical scavenging of DPPH and FRAP methods.</p> <p><strong>Results:</strong> The results obtained indicated a variation of total polyphenols and flavonoids content according to the type of extract. Hydro-ethanolic extract of the various plants studied has a high polyphenols and flavonoids content. In variable proportions, all the extracts tested reduced the DPPH radical and ferric iron, reflecting their antioxidant potential. The best antioxidant activity has been obtained with the hydro-ethanolic extracts.</p> <p><strong>Conclusion:</strong> This study showed that all the plant's extracts studied have antioxidant activity that varies with the type of extract. However, the hydro-ethanolic extractions showed the best antioxidant activities. The data obtained in the present study justified the use of these plants in management of pathologies involving oxidative stress.</p> Jean Robert Klotoé Eric Agbodjento Victorien Tamègnon Dougnon Mahudro Yovo Téniola Isabelle Sacramento Esther Déguénon Jacques Tossou Dougnon Jean Marc Atègbo ##submission.copyrightStatement## 2020-04-01 2020-04-01 1 12 10.9734/jpri/2020/v32i430418 Outpatient Doxycycline Therapy: Frequency of Its Use and Its Prescribing Patterns in a Public Hospital <p><strong>Aim: </strong>The aim of this study was to identify the outpatient doxycycline therapy: Frequency of its use and its prescribing patterns in a public hospital.</p> <p><strong>Methodology: </strong>This was a retrospective study which was conducted in a public hospital in Alkharj City in 2018. The outpatient prescriptions were reviewed to evaluate the prescription patterns of Doxycycline.</p> <p><strong>Results:</strong> The study results found that about 48.38% of the patients were female and about 62.90% were from Saudi Arabia. Doxycycline was prescribed mainly by resident physicians. Doxycycline was prescribed mainly in the emergency department followed by obstetrics &amp; gynecology department.</p> <p><strong>Conclusion: </strong>Doxycycline was prescribed infrequently in the outpatient settings; it is reserved only for specific conditions. It is important to use antibiotics wisely by the patients and to prescribe and dispense antibiotics including doxycycline appropriately by health care professionals.</p> Nehad J. Ahmed ##submission.copyrightStatement## 2020-04-04 2020-04-04 13 17 10.9734/jpri/2020/v32i430419 The Prescribing Trends of Metronidazole in The Outpatient Setting <p><strong>Aim:</strong> The aim of this study is to characterize the trends of metronidazole prescribing in outpatient setting in Alkharj.</p> <p><strong>Methodology: </strong>This is a retrospective study includes evaluating outpatient antibiotic prescriptions from 01-01-2018 till 31-12-2018 in a public hospital Alkharj. The data were collected and analyzed using excel software and the descriptive data were represented by frequencies and percentages.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</p> <p><strong>Results:</strong> The majority of the metronidazole prescriptions were regular and only few prescriptions were urgent. The physicians who prescribed metronidazole were mainly residents who don’t have sufficient experience that may results in more inappropriate antibiotic prescribing patterns.</p> <p><strong>Conclusion</strong><strong>:</strong> The excessive use of metronidazole in addition to its prescribing by resident may results in inappropriate prescribing pattern that may lead to increase the adverse effect which may lead to increase the rate of bacterial resistance. More efforts are needed, especially by applying antimicrobial stewardship program, to ensure that metronidazole is prescribed correctly.</p> Nehad J. Ahmed ##submission.copyrightStatement## 2020-04-06 2020-04-06 24 29 10.9734/jpri/2020/v32i430421 The Impact of Zinc Oxide Nanoparticle on LH, FSH, and Testosterone Hormones in Mature Male NMRI Rats <p>Nanoparticles are widely applied in all aspects of modern life because of their unique features such as small size and high surface area. Several types of research have been carried out to discover the feasible detrimental impacts of Nano-particles on human reproduction. The purpose of this study was to examine the impact of zinc oxide nanoparticles in mature male rats through examining LH, FSH, and testosterone sex hormones. Therefore, 30 Naked Mole-<em>Rat</em> Initiative (NMRI) rats were divided into 5 groups. Different doses of zinc oxide nanoparticles (250, 500 and 700<sup>-1</sup>) were intra peritoneally injected to animals only once. Then, the serum level of luteinizing hormone (LH), Follicle Stimulating Hormone (FSH), and testosterone hormones were measured using Enzyme-Linked Immunosorbent Assay (ELISA) method after 21 days. The results were analyzed by ANOVA and Tukey tests. The results indicated that zinc oxide nanoparticles doses caused a significant increase in FSH and testosterone level of blood (Respectively) in 250 and<sup>-1</sup> in comparison with the control group. Moreover, this research illustrated that zinc oxide nanoparticle can cause a dose-related increase in Testosterone and FSH hormones levels while causing no significant change in LH hormone level.</p> Ziba Mozaffari Kazem Parivar Nasim Hayati Roodbari Shiva Irani ##submission.copyrightStatement## 2020-04-06 2020-04-06 30 37 10.9734/jpri/2020/v32i430422