http://journaljpri.com/index.php/JPRI/issue/feed Journal of Pharmaceutical Research International 2019-11-21T11:48:59+00:00 Journal of Pharmaceutical Research International contact@journaljpri.com Open Journal Systems <p style="text-align: justify;"><strong>Journal of Pharmaceutical Research International (ISSN:&nbsp;2456-9119)</strong> is dedicated to publish&nbsp;high quality papers (<a href="/index.php/JPRI/general-guideline-for-authors">Click here for Types of paper</a>)&nbsp;in all areas of pharmaceutical Science including pharmaceutical drugs, community pharmacy, hospital pharmacy, clinical pharmacy, compounding pharmacy, consultant pharmacy, internet pharmacy, veterinary pharmacy, nuclear pharmacy, military pharmacy, pharmacy informatics, pharmaceutics, medicinal chemistry, pharmacognosy, pharmacotherapy, pharmacodynamics, pharmacokinetics, clinical pharmacology, neuropharmacology, psychopharmacology, pharmacogenetics, pharmacogenomics, pharmacoepidemiology, toxicology, theoretical pharmacology, posology, pharmacognosy, behavioral pharmacology, environmental pharmacology, medicine development and safety testing, drug legislation and safety.&nbsp;The journal also encourages the submission of useful reports of negative results. This is a quality controlled,&nbsp;OPEN&nbsp;peer reviewed, open access INTERNATIONAL journal.</p> http://journaljpri.com/index.php/JPRI/article/view/30313 Study of the Role of New Technologies in Pharmaceutical Industry 2019-11-21T06:49:09+00:00 Zaffar Ahmed Shaikh zashaikh@bbsul.edu.pk Anwar Ali Sathio Asif Ali Laghari Mashooq Ahmed Memon Ibrar Hussain Mirani <p>The objective of this study was to assess the importance and impact of new technologies in the pharmaceutical industry. The study also explores strategic visions for the development of technical requirements, the recognition of IT inventions that support patient care services and the assessment of pharmacists’ willingness to adopt inventions. The assumptions were therefore to assess the impact, positive or negative, of the use of new technologies on the pharmaceutical industry. Two kinds of respondents took part in collecting primary and secondary datasets. Thus, 100 participants were selected for questionnaire and 15 for interview-based data input. Pharmacy students, teachers/researchers, and employees of the pharmaceutical companies were included. The study concludes that new technologies have had a positive effect on the growth of the pharmaceutical industry. About the future, it is concluded that new technologies will give the pharmaceutical industry more advantages in expanding their businesses in their chosen fields. On the other hand, it is also concluded that some of the respondents are not satisfied with some technologies used. The study recommends that pharmacists organize training courses to educate employees on new technologies. It also suggests that Artificial Intelligence should be implemented in the pharmaceutical sector, which may not reduce the employment of individuals because this will lead to a considerable loss of Artificial Intelligence errors.</p> 2019-11-18T00:00:00+00:00 ##submission.copyrightStatement## http://journaljpri.com/index.php/JPRI/article/view/30315 Phytochimic Study, Antioxidant Activity and Nutritional Interest of Extracts from Leaves of Khaya senegalensis (Desr) A. Juss (Meliaceae) Collected in the Northern Cote d'ivoire 2019-11-21T10:08:47+00:00 Kone Monon konemonon2017@gmail.com Traore Youssouf Zanga Konan Kouadio Fernique Toure Abdoulaye Koko Kouakou Konan Henri Joel Ouattara Karamoko Coulibaly Adama <p>Medicinal and food plants contain a large number of metabolites that have multiple interests in pharmacology, cosmetology and the food industry. The aim of this study was to determine the content of phenolic and flavonoid compounds, to evaluate the antioxidant activity and to raise the nutritional interest of extracts from leaves of <em>Khaya senegalensis</em>. The methodological approach consisted of carrying out extractions with distilled water, ethanol, methanol and butanol. The extracts thus obtained were subjected to phytochemical analysis by spectrophotometric assay to determine the content of minerals, total phenols and flavonoids and to evaluate the antioxidant activity. The investigations revealed that <em>K. senegalensis</em> leaves extract have a high calcium content (948.38 ± 11.57 mg / 100 g), magnesium (188.24 ± 0.97 mg / 100 g), phosphorus (304.98 ± 2.6 mg / 100 g) and iron (41.50 ± 1.57 mg / 100 g). A high content of total phenols and flavonoids was observed with butanol extract (91.53 ± 0.04 mg EAG / g extract) and (75.58 ± 0.05 mg EQ / g extract) respectively. The ethanol and methanol extracts recorded the best performances by reducing the residual iron while the aqueous and butanol extracts obtained the IC<sub>50</sub> values closest to those of the reference viz vitamin C and BHT. This studyshowed that <em>K. senegalensis</em> leaves are a source of active substances known for their therapeutic and nutritional properties. The leaves of <em>K. senegalensis</em> could be used to treat various pathologies and also as an alternative in cattle feeding.</p> 2019-11-21T00:00:00+00:00 ##submission.copyrightStatement## http://journaljpri.com/index.php/JPRI/article/view/30316 Community Pharmacists' Knowledge, Attitudes and Practices towards the Use of Herbal Remedies 2019-11-21T10:20:36+00:00 Nehad J. Ahmed n.ahmed@psau.edu.sa Mohd F. Khan <p><strong>Background: </strong>The use of herbal medicines and natural health products by the public is continuously being increased by the day. Community pharmacists are the most accessible healthcare providers, this necessitates that pharmacists should be aware of the appropriate use of herbal medicines.</p> <p><strong>Objective: </strong>The objective of the present study was to assess the knowledge, attitude and practice of community pharmacists in the Al-Kharj region.</p> <p><strong>Methodology: </strong>A cross-sectional study was carried out amongst pharmacists who work in different community pharmacies in Al-Kharj, Saudi Arabia. The questionnaire was prepared using surveys of previous studies and was hand-delivered to the pharmacists concerning the use of herbal medicines.</p> <p><strong>Results:</strong> All of the respondents were male and more than 50% of them were in the age range between 30-39. Most of the pharmacists reported that they have sufficient information about dietary supplements and that they are interested in updating their knowledge&nbsp; about herbal drugs. Furthermore, more than 70% of the participants said that they take both medical and medication history from the buyers before supplying herbal medicines.</p> <p><strong>Conclusion:</strong> The study shows that pharmacists have good knowledge and a positive attitude toward using herbal medicines by the public in Al-Kharj city.</p> 2019-11-21T00:00:00+00:00 ##submission.copyrightStatement## http://journaljpri.com/index.php/JPRI/article/view/30318 Development and Validation of Ultra High Performance Liquid Chromatographic (UHPLC) Method for the Determination of Roxithromycin in the Broiler Plasma 2019-11-21T11:48:59+00:00 R. D. Singh ratn1709@yahoo.com S. K. Mody H. B. Patel V. N. Sarvaiya B. R. Patel S. B. Gondaliya <p><strong>Aims: </strong>The present study was designed to develop and validate the UHPLC method for quantitative determination of roxithromycin, a macrolide antimicrobial drug, in broiler plasma for the application of pharmacokinetic studies.</p> <p><strong>Methodology:</strong> UHPLC apparatus comprised of ultraviolet (UV) detector was used in the present study. Chromatographic separation was performed by using reverse phase C18 column. Mobile phase was combination of buffer and 55 acetonitrile in the ratio of 55: 45. Buffer part used was 0.1% trifluoroacetic acid (v/v) having pH of 2.1. Erythromycin was used as an internal standard. Isocratic elution mode was employed with flow rate of 1 ml/min and effluents were monitored at wavelength of 220 nm. Liquid-liquid extraction using ice-cold acetonitrile was performed to extract roxithromycin from plasma samples. The data integration was performed using Chromeleon™ version 6.8 software.</p> <p><strong>Results:</strong> The linear calibration curve with a mean correlation coefficient (R<sup>2</sup>) value of 0.9999 was observed for concentrations ranging from 0.20 to 12.80 µg/ml. At any concentration, accuracy was not found to be less than 90%. The mean extraction recovery (n=5) for concentrations of 0.40 µg/ml was 81.36%. The calculated intraday and interday C.V. % was not more than 7.70% and 9.42%, respectively, at any concentration studied. The specificity of the analysis was reflected by the narrow range of retention time ranging between 6.983 to 7.178 minutes. LOD and LOQ of the method under investigation were calculated as 0.131 and 0.398 µg/ml, respectively.</p> <p><strong>Conclusion:</strong> A reliable, reproducible, accurate, precise, specific and sensitive method for analysis of roxithromycin in broiler plasma was developed and validated for application in the pharmacokinetic study of the roxithromycin.</p> 2019-11-21T00:00:00+00:00 ##submission.copyrightStatement##