Stomach Cancer and Parabens

Main Article Content

Lama Alloujami
Sophi Barguil

Abstract

Background and Objectives: Parabens are one of the chemicals used widely in preserving foods and pharmaceutical preparations. Although it was safe for many years, recently it has been proven that its action mimics estrogen in the body when it is linked to its receptors, known as estrogen receptors which are present in many systems of the body and that it may have a link with breast cancer, especially after it was found in samples of breast cancer. As known that estrogen receptors are placed in different areas in the body, including the stomach, therefore it may have a role in cancer formation and development in the stomach.

The purpose of this manuscript is to investigate the presence of Methyl, Ethyl and Propylparaben in stomach cancer in men and women.

Methods: Samples of stomach cancer have been collected immediately after surgery in Al Assad University Hospital and after extracting parabens from samples, they have been analyzed by HPLC / MS in the science faculty at Damascus University.

Results: All samples have the three types of parabens with total mean concentration (22.5 ± 0.4 ng/g).

The concentration of Methylparaben was the highest (8.2 ± 0.3 ng/g) then Propylparaben (7.4 ± 0.4 ng/g) and finally Ethylparaben (6.9 ± 0.2 ng/g).

Conclusion: Because of the presence of parabens in all stomach cancer samples, so more studies must be done to research if parabens may have any effect in the formation of abnormal cells and the formation of cancer in the body systems which have estrogen receptors.

Keywords:
Methylparaben, ethylparaben, propylparaben, stomach, cancer.

Article Details

How to Cite
Alloujami, L., & Barguil, S. (2020). Stomach Cancer and Parabens. Journal of Pharmaceutical Research International, 32(1), 18-24. https://doi.org/10.9734/jpri/2020/v32i130390
Section
Original Research Article

References

World Cancer Report world health organization; 2015.

National Cancer Institute (NCI); 2018.

World Health Organization. International Agency for Research on Cancer (IARC). Latest global cancer data; 2018.

American institute for cancer research. Stomach Cancer Statistics; 2018.

Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A. Global cancer statistics. Globocan estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2018; 68(6):394-424.

Brand W, Boon PE, Hessel EVS, Meesters JAJ, Weda M, Schuur AG. The Netherlands Food and Consumer Product Safety Authority (NVWA). National Institute for Public Health and the Environment. Exposure to and toxicity of methyl- ethyl and propylparaben. RIVM Report. 2017:1-109.

Rahul S. Tade, Mahesh P. More, Chatap VK, Deshmukh PK, Patil PO. Safety and toxicity assessment of parabens in pharmaceutical and food products. Inventi Rapid: Pharmacy Practice. 2018;(3).

Scientific Committee on Consumer Safety (SCCS), Opinion on Parabens; 2010.

Darbre PD, Aljarrah A, Miller WR, Coldham NG, Sauer MJ, Pope GS. Concentrations of parabens in human breast tumours. J Appl Toxicol.2004; 24(1):5-13.

Millas I, Liquidato BM. Estrogen receptors alpha and beta in non-target organs for hormone action. Braz J Morphol Sci. 2009;26(3-4):193-197.

Hogan AM, Collins D, Baird AW, Winter DC. Estrogen and gastrointestinal malignancy. Mol Cell Endocrinol. 2009; 307(1-2):19-24.

Saif Ur Rahman, Cao MJ. Estrogen receptors in gastric cancer: Advances and perspective. World J Gastroenterol. 2016; 22(8):2475–2482.

Xu CY, Guo JL, Jiang ZN, Xie SD, Shen JG, Shen JY, Wang LB. Prognostic role of estrogen receptor alpha and estrogen receptor beta in gastric cancer. Annals of Surgical Oncology. 2010;17(9):2503- 9.

Barr L, Metaxas G, Harbach CAJ, Savoy LA, Darbre PD. Measurement of paraben concentrations in human breast tissue at serial locations across the breast from axilla to sternum. J Appl Toxicol.2012; 32(3):219-32.

Cancer Research UK. Stomach Cancer Incidence Statistics; 2019.

Layke JC, Lopez PP. Gastric cancer: Diagnosis and treatment options. American Family Physician. 2004;69(5): 1133-40.

Koeppe ES, Ferguson KK, Colacino JA, Meeker JD. Relationship between urinary triclosan and paraben concentrations and serum thyroid measures in NHANES 2007-2008. Sci Total Environ. 2013;445-446: 299-305.

Anjan Nan. Side effects of drugs annual. Chapter 47-miscellaneous drugs, materials, Medical Devices and Techniques. 2015;(37):603-619.