The Effect of Vitamin B6 on Reducing the Number and the Size of Breast Cysts and the Amount of Recurrence after Aspiration in Women

Main Article Content

Setareh Soltany
Hamid Reza Hemmati
Jafar Alavy Toussy
Parisa Alavi Toosi

Abstract

Introduction: Palpable breast lumps are one of the most prevalent breast problems in women who visit a doctor. Most of these lumps are benign, and many of these benign lumps, have cystic nature. One of the suggested treatments for breast cyst is vitamin B6 intake. So, this study aimed to determine the effect of vitamin B6 on reducing the number and the size of breast cysts and reducing the amount of recurrence after aspiration.

Materials and Methods: This study is a double-blind randomized clinical trial. Patients simply divided into two groups randomly, intervention group (receiving 150 mg vitamin B6 twice a day for two months) and control group (placebo). After data collection, the database produced, and information came in by SPSS-22 software. Descriptive results extracted in the form of tables and graphs. In all cases was used α=0.05.

Results: At the end of the study, 65 patients (34 people in the intervention group, and 31 people in the control group) studied. At the end of the survey in the non-palpable cysts, was observed a significant decrease in the number and the size of breast cysts in each group receiving vitamin B6 or placebo. Still, the difference was not significant in comparing the two groups. 19 patients (2.29%) had palpable cysts that aspiration performed in all cases. After the study period, no recurrence of cysts observed in any of the intervention and control groups.

Conclusion: The study showed that vitamin B6 had no effect on reducing the size and the number of non-palpable breast cysts and prevent recurrence of palpable cysts after aspiration.

Keywords:
Breast cyst, vitamin B6, fibrocystic changes.

Article Details

How to Cite
Soltany, S., Reza Hemmati, H., Alavy Toussy, J., & Alavi Toosi, P. (2019). The Effect of Vitamin B6 on Reducing the Number and the Size of Breast Cysts and the Amount of Recurrence after Aspiration in Women. Journal of Pharmaceutical Research International, 31(6), 1-7. https://doi.org/10.9734/jpri/2019/v31i630348
Section
Original Research Article

References

Morrow M. The evaluation of common breast problems. Am Fam Physician. 2000;61(8):2371-2378.

Heisey R, Mahoney L, Watson B. Management of palpable breast lumps, Consensus guideline for family physicians. Can Fam Physician. 1999;4(5):1926-1932.

Bery WG, Sechtin A, Marques H, Zhang ZH. Cystic breast masses and the ACRIN666 Exprience. Radiol Clin North Am. 2010;48(5):931-987.

Biggs W, Demuth R. Premenstrual syndrome and premenstrual dysphoric disorder. Am Fam Physician. 2011;84(8): 918-24.

Lin J, Lee IM, Cook NR, Sellhub J, Manson JE, et al. Plasma folate, vitamin B-6, vitamin B-12, and risk of breast cancer in women. Am J Clin Nutr. 2008;8(7):734- 43.

Bendich A. The potential for dietary supplements to reduce premenstrual syndrome symptoms. Journal of American College of Nutrition. 2000;19(1):3- 12.

Smallwood J, Ah-key D, Taylor I. Vitamin B6 in the treatment of premenstural mastalgia. Br J Clin Pract. 1986;40(12): 532-3.

Salehi L, Salehi F. Evaluation of effect of vitamin B6 on PMS. Scientific Journal of Kordistan Journal of Medical Science. 2007;12(3):32-39.

Soltany S, Alavy Toussy J. The effect of vitamin B6 on cyclic and non-cyclic Mastalgia. Advances in Environmental Biology. 2014;8(6):2936-2939.

Donegan WL. Evaluation of a palpable breast masses. N Engl J Med. 1992; 327(13):937-941.

Hartlage SA, Freels S, gotman N, Yonkeres K. Criteria for premenstrual dysphoric disorder. Arch Gen Psychiatry. 2012;69(3):300-5.

Nuray Voyvoda. Simple breast cysts: should we treat or not. Diagn Interv Radiol. 2017;23(1):86.

Brenner RJ, Bein ME, Sarti DA and Vinstein AL. Spontaneous regression of interval benign cysts of the breast. Radiology. 1994;19(3):365-368.

Horner NK, Lampe WL. Breast condition shows inadequate evidence of effectiveness. J Am Diet Assoc. 2000; 100(11):1368-1380.

Brush MG, Perry M. Pyridoxine and the premenstural syndrome. Lancet. 1985; 1(8442):1399.

Ciambellotti E, Favero A.Therapeutic results with a vitamin complex (A,E,B6) in fibrocystic mastopathies. Minevra Med. 1997;68(18):1249-52.

Wendie B, Campassi CI, Ioffe OB. Cystic lesion of the breast Sonographic pathologic correlation. Radiology. 2003; 22(7):183-191.

Morrow N, Schmidt RA, Bucci C. Breast conservation for mammographically occult carcinoma. Anu Surg. 1998;22(7):502- 6.

Wyatt KM, Dimmock WP, Jones PW, O’Brein PMS. Efficacy of Vitamin B6 in the treatment of premenstrual syndrome: Systematic review. BMJ. 1999;3(18):1375-1381.

Chakmakjian ZH, Higgins CE, Abraham GE. The effect of a nutritional supplement, Optivite for women, on premenstrual tension syndromes. J Appl Nutr. 1985; 3(7):12­7.