An Overview of Different Synthetic Routes for the Synthesis of Phthalazine Derivatives

Main Article Content

Smita Singh
Nitin Kumar

Abstract

This review paper describes the different synthetic routes used for the synthesis of substituted phthalazine derivatives. Phthalazines have been used as building blocks for the synthesis of a new molecule with heterocyclic structure. These new molecules are highly useful in medicinal chemistry for the researchers leading to the further development of new molecules which have potency and effectiveness to produce a desired pharmacological response.

Keywords:
Phthalazine, phthalazinone, thiazolo, phthalic anhydride.

Article Details

How to Cite
Singh, S., & Kumar, N. (2019). An Overview of Different Synthetic Routes for the Synthesis of Phthalazine Derivatives. Journal of Pharmaceutical Research International, 27(6), 1-15. https://doi.org/10.9734/jpri/2019/v27i630189
Section
Review Article

References

Nahed F, Ghaffar AE, Mona A, Ghanem HM, Zaki HM. Synthesized and biochemical evaluation of some substituted phthalazines. Journal of American Science. 2011;7:771-781.

Aziz MA, Youssef A, Essam I. Synthesised some annelated phthalazine derivatives and acyclo C-nucleosides from 1-chloro-4-(2, 4, 6-trimethylphenyl) phthalazine precursor, and evaluated their antimicrobial. Turk. J. Chem. 2012;36:347–366.

Quan ZS, Sun XY, Guan LP. Chem. Biol. Drug Des. 2009;73:313-319.

Gschwind HP, Jalava T. Drug Metabolism and Disposition. 2006;34:1817.

Zhang S, Zhao Y, Liu Y, Chen D, Lan W, Zhao Q, Dong C, Xia L, Gong P. Synthesised and evaluated their anticonvulsant activity of 6-Alkoxy [1,2,4]Triazolo[3,4-a]Phthalazines. Eur. J. Med. Chem. 2010;45:3504.

Sun X, Hua C, Deng X, Wei C, Sun Z, Quan Z. Evaluation of the anticonvulsant activity of 6-(4-chlorophenyoxy)-tetrazolo[5,1-a] phthalazine in various experimental seizure models in mice. Eur. J. Med. Chem. 2010;45:4807.

Dogruer DS, Kupeli E, Yesilada E, Sahin MF. Arch Pharm (Weinheim). 2004;337: 303-310.

Haack T, Fattori R, Pellacini F, Fronza G, Ganazzoli F. Phthalazine PDE IV inhibitors: Conformational study of some 6-methoxy-1,4-disubstituted derivatives. Bioorganic & Medicinal Chemistry. 2005;13:4425-4433.

Napoletano M, Norcini G, Pellacini F, Marchini F, Morazzoni G. Bioorg Med Chem Lett. 2000;10:2235-2238.

Nomoto Y, Obase H, Takai H, Teranishi M, Nakamura J. Chem Pharm Bull. 1990;38: 2179-2183.

Sun XY, Quan ZS, Sun ZG, Deng XQ. Eur. J. Med. Chem. 2010;45:4807-12.

Sung Kim J, Lee HJ, Suh ME, Choo HY, Lee SK. Synthesis and cytotoxicity of 1-substituted 2-methyl-1H-imidazo[4,5-g]phthalazine-4,9-dione derivatives. Bioorg Med Chem. 2004;12:3683-3686.

Haider N, Kabicher T, Käferböck J. Plenk, A. 2007;12:1900-1909.

Lebsack AD, Gunzner J, Wang B, Pracitto R, Schaffhauser H, Santini A, Aiyar J, Bezverkov R, Munoz B, Liuc W. Venkatraman S. Synthesised of [1,2,4]triazolo[3,4-a]phthalazine derivatives as high-affinity ligands to the subunit of voltage gated calcium channel. Bioorg. & Med. Chem. Lett. 2004;14:2463.

Shetgiri NP, Nayak BK. Ind J Chem. 2005;44B:1267-1272.

Bayoumi WA, Barghash AM, Gineinah, MM, Massoud MA. Design synthesis and antioxidant evaluation of certain new phthalazine derivatives. Der. Pharma Chemica. 2014;6:89-102.

Lukacs G, Simig G. Synthesis of new 1,2-Dihydrophthalazines. Heterocyclic Chem. 2002;39:989.

Jhang L, Guan LP, Sun XY. Synthesised and evaluated their anticonvulsant activity of 6-Alkoxy [1,2,4]Triazolo[3,4-a]Phthalazines. Chem Biol Drug Des. 2009;73:313-319.

De P, Yoya GK, Constant P, Bedos-Belval, F, Duran H, Saffon N, Daffe M, Baltas. Synthesis and anticancer activity evaluation of 2(4-alkoxyphenyl)cyclopropyl hydrazides and triazolo phthalazines. M. J. Med. Chem. 2010;54:1449.

Sani M, Belotti D, Giavazzi R, Panzeri W, Volonterio A, Zanda M. Tetrahedron Lett. 2004;45:1611.

El Azm FSA, Mahmoud MR, Hekal MH. Recent developments in chemistry of phthalazines. Organic Chemisrty Current Research. 2015;4:1-12.

Shubin KM, Kuznetsov VA, Galishev VA. Synthesis of benzo[4,5]imidazo[2,1-a]phthalazines. Tetrahedron Letters. 2004;45:1407–1408.

Aly AA, Gad El-Karim IA. Phosphorus, Sulfurand Silicon. 2005;180:1997-2011.